Papers by Mohammed Hawsawi
New 1,2,4-oxadiazole derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease: design, synthesis, and biological evaluation
BMC chemistry, Jul 13, 2024
Design and Synthesis of Quinoxaline Hybrids as Modulators of HIF-1a, VEGF, and p21 for Halting Colorectal Cancer
ACS omega, May 29, 2024
Exploring Fluorine-Substituted Piperidines as Potential Therapeutics for Diabetes Mellitus and Alzheimer’s Diseases
European journal of medicinal chemistry, Jul 1, 2024
Electrochemical and Photocatalytic Synthesis of Organic Compounds Utilizing a Greener Approach. A review
Molecular catalysis, Apr 1, 2024
Review on PEDOT:PSS-Based Conductive Fabric
ACS Omega
Carbohydrate Research, 2020
The oxidative deamination of N-nitroso N-acetylneuraminic acid (NeuAc) derivatives is a useful re... more The oxidative deamination of N-nitroso N-acetylneuraminic acid (NeuAc) derivatives is a useful reaction for the formation of 5-desamino-5-hydroxy NeuAc derivatives and their stereoisomers. We demonstrated previously that replacement of the classical nucleophile in these reactions, acetic acid, by phenols resulted in a novel double displacement process with substitution of the acetoxy group at the 4-position taking place in addition to that of the 5-acetamido group, for which we postulated a mechanism centered on the formation of a highly reactive vinyl diazonium ion. We now extend these studies to encompass the use of hydroxylamine-based systems and weakly basic amines as nucleophile. We find that the nature of the product depends significantly on the pKa of the nucleophile, with the more acidic species typically affording only substitution at the 5position, while the less acidic species give mixtures of elimination products and disubstitution products. The use of aniline as nucleophile is of particular note as it affords a novel aziridine spanning positions 4-and 5-of the neuraminic acid skeleton.
I would like to thank my advisor during my Master's Degree, prof. Christina Goudreau Collison. Sh... more I would like to thank my advisor during my Master's Degree, prof. Christina Goudreau Collison. She was helpful and supported me to pursue a PhD in chemistry. I would like to appreciate Prof. Anura Wickramasinghe, who I considered my second advisor, and who helped me to learn many skills. I really enjoyed working with him. I would like to thank my labmates in the Crich group. The postdocs during my time in the
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Papers by Mohammed Hawsawi