Hongxun Tao

Jiangsu University, School of Food and Biological Engineering, Faculty Member

Follower

Following

Public Views

CDUTCM, B.S., TCM;
SHUTCM, M.S., TCM;
UMAC, Ph.D, BM.
2021.06~ Jiangsu University, Zhenjiang, Jiangsu Province, China.
Interest: Edible medicinal botanicals; Functional foods; Natural products.
Focus: Low GI food; Glucose and lipid metabolism.
Strategy: Dietary intervention; Multi-omics; Network pharmacology.
Welcome to discuss and exchange ideas！Open to cooperation！
ResearcherID ABC-5367-2021;
Scopus ID: 56100492500;
https://orcid.org/0000-0001-8368-457.
Address: Jiangsu University, Xuefu Road 301, Jingkou District, Zhenjiang, Jiangsu Province, China, 212013

less

Interests

Uploads

Papers by Hongxun Tao

Pharmacodynamic material basis and pharmacological mechanisms of Cortex Mori against diabetes mellitus

Journal of Ethnopharmacology, Dec 31, 2023

Recombinant microgels utilized to formulate green Pickering emulsions

Food Hydrocolloids, Apr 30, 2024

A comprehensive review on the ethnobotany, phytochemistry, pharmacology and quality control of the genus <i>Lycium</i> in China

Food & Function, 2023

The distribution, botanical features, and chemical compounds of the Lycium genus in China, as wel... more

Direct Analysis in Real-time Mass Spectrometry for Rapid Identification of Traditional Chinese Medicines with Coumarins as Primary Characteristics

Phytochemical Analysis, Nov 23, 2016

Download

Water-in-oil oleogel with biphasic stabilization for fabrication of low-fat salad dressing

Food Hydrocolloids, Sep 1, 2023

Improved antioxidant activity of rutin via lipase‐mediated esterification with oleic acid

Journal of the Science of Food and Agriculture, Feb 21, 2023

BACKGROUNDOxidation is a major problem for oils and fats, which can be mitigated by antioxidants.... more BACKGROUNDOxidation is a major problem for oils and fats, which can be mitigated by antioxidants. Rutin has excellent antioxidant activity, but its poor lipid solubility greatly limits its practical application. In this study, an efficient enzymatic synthesis route of lipophilic rutin ester was established using oleic acid as an acyl donor, and the antioxidant potential of rutin oleate was evaluated for the first time by proton (1H) nuclear magnetic resonance (NMR) spectroscopy.RESULTSThe synthesized product was finally identified as rutin oleate by Fourier transform infrared, high‐performance liquid chromatography–mass spectrometry, and 1H, carbon‐13, and DEPT‐135 NMR analyses, and the acylation site was the 4‴‐OH of the rhamnose group in the rutin molecule. The maximum conversion was over 93% after 48 h of reaction using Novozym 435 as catalyst under the best conditions among these tests. The conversion of rutin ester decreased with the increase of carbon chain length and the number of carbon–carbon double bonds of the fatty acid molecule. Most importantly, rutin oleate exhibited antioxidant capacity comparable to butylated hydroxytoluene and its counterparts (rutin and oleic acid) at low temperatures (60° C), but had a significant advantage at high temperatures (120° C).CONCLUSIONThe antioxidant activity of rutin was significantly enhanced by lipase‐mediated esterification with oleic acid. Therefore, rutin oleate could be further developed as a novel antioxidant for use in oil‑ and fat‐based foods. © 2023 Society of Chemical Industry.

Conformational changes and the formation of new bonds achieving robust nanoemulsions by electrostatic interactions between whey protein isolate and chondroitin sulfate

Food Hydrocolloids, Mar 1, 2023

CETSA and thermal proteome profiling strategies for target identification and drug discovery of natural products

Phytomedicine, Jul 1, 2023

Water-in-oil oleogel with biphasic stabilization for fabrication of low-fat salad dressing

Food Hydrocolloids

Prospects for the application of traditional Chinese medicine network pharmacology in food science research

Journal of the Science of Food and Agriculture

There has always been a particular difficulty with in‐depth research on the mechanisms of food nu... more There has always been a particular difficulty with in‐depth research on the mechanisms of food nutrition and bioactivity. The main function of food is to meet the nutritional needs of the human body, rather than to exert a therapeutic effect. Its relatively modest biological activity makes it difficult to study from the perspective of general pharmacological models. With the popularity of functional foods and the concept of dietary therapy, and the development of information and multi‐omics technology in food research, research into these mechanisms is moving towards a more microscopic future. Network pharmacology has accumulated nearly 20 years of research experience in traditional Chinese medicine (TCM), and there has been no shortage of work from this perspective on the medicinal functions of food. Given the similarity between the concept of ‘multi‐component‐multi‐target’ properties of food and TCM, we think that network pharmacology is applicable to the study of the complex mech...

Conformational changes and the formation of new bonds achieving robust nanoemulsions by electrostatic interactions between whey protein isolate and chondroitin sulfate

Food Hydrocolloids

Improving Energy Efficiency in Internet of Things using Artificial Bee Colony Algorithm

Recent Patents on Engineering, 2021

Background: With the advent of IoT, the deployment of batteries with a limited lifetime in remote... more Background: With the advent of IoT, the deployment of batteries with a limited lifetime in remote areas is a major concern. In certain conditions, the network lifetime gets restricted due to limited battery constraints. Subsequently, the collaborative approaches for key facilities to reduce the constraint demands of the current security protocols. Objective: This work covers and combines a wide range of concepts linked by IoT based on security and energy efficiency. Specifically, this study examines the WSN energy efficiency problem among IoT devices and security for the management of threats in IoT through collaborative approaches and finally outlines the future. The concept of energy-efficient key protocols which clearly cover heterogeneous IoT communications among peers with different resources has been developed. Because of the low capacity of sensor nodes, the energy efficiency in WSNs has been an important concern. Methods: In this paper, we present an algorithm for Artificial...

Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola Crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

Food Science and Human Wellness

Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in C... more Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China. Interestingly, our previous work has found that R. crenulate extract (RCE) could significantly improve the pathology associated with dextran sulfate sodium-induced colitis. Thus, the current research aims to reveal the pharmacodynamic material basis of RCE, as well as its mechanism against colitis. The chemical characterization of RCE was performed by UHPLC-HR-MS, through which a total of 88 constituents were identifi ed. Meanwhile, our results also found 29 constituents absorbed into blood and 8 metabolized absorbable compounds. The decreased fl avonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of colitis. The metabolomics study revealed that colitis caused the alternation of fatty acid metabolism, steroid hormone biosynthesis and bile acid metabolism. Correspondingly, RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.

Download

Prospects for the application of traditional Chinese medicine network pharmacology in food science research

There has always been a particular difficulty with in-depth research on the mechanisms of food nu... more There has always been a particular difficulty with in-depth research on the mechanisms of food nutrition and bioactivity. The main function of food is to meet the nutritional needs of the human body, rather than to exert a therapeutic effect. Its relatively modest biological activity makes it difficult to study from the perspective of general pharmacological models. With the popularity of functional foods and the concept of dietary therapy, and the development of information and multi-omics technology in food research, research into these mechanisms is moving towards a more microscopic future. Network pharmacology has accumulated nearly 20 years of research experience in traditional Chinese medicine (TCM), and there has been no shortage of work from this perspective on the medicinal functions of food. Given the similarity between the concept of 'multi-component-multi-target' properties of food and TCM, we think that network pharmacology is applicable to the study of the complex mechanisms of food. Here we review the development of network pharmacology, summarize its application to 'medicine and food homology', and propose a methodology based on food characteristics for the first time, demonstrating its feasibility for food research.

Download

Chemical compositions, pharmacological activities, quality control studies of Erycibes plants, and the development of their substitutes

Phytotherapy Research, 2021

Erycibes are members of the Convolvulaceae family, including more than 10 species worldwide that ... more Erycibes are members of the Convolvulaceae family, including more than 10 species worldwide that are distributed in tropical Asia. Some Erycibes species have long been used as traditional remedies for rheumatoid arthritis, fever, hepatitis, and liver injury in China and Thailand. A total of 152 compounds from Erycibes plants have been isolated and identified, categorized as flavonoids, coumarins, quinic acid derivatives, lignans, and alkaloids. Coumarins are the characteristic and active constituents of this species, including scopoletin and scopolin. Modern pharmacological studies have shown that the extracts and bioactive components of Erycibes plants exhibit several biological activities, including antiinflammatory, analgesic, hepatoprotective, anti‐gout, antitumor, antioxidation, and other therapeutic effects. However, in recent years, due to destructive exploitation and utilization, some Erycibes plants' natural resources have become rare or endangered. Developing substitutes is a strategy to alleviate the pressure on those endangered medicinal plant resources. To provide a scientific basis for the development and protection of those threatened Erycibes species, this review summarized the current status of the chemical compositions, pharmacological activities, quality control studies, and the development of substitutes for Erycibes plants. In particular, the rationale for use of Porana sinensis currently on the market is discussed.

Dietary intervention with edible medicinal plants and derived products for prevention of Alzheimer's disease: A compendium of time-tested strategy

Journal of Functional Foods, 2021

Alzheimer's disease (AD) is acccounting for over 50% of all cases of dementia worldwide. Currentl... more Alzheimer's disease (AD) is acccounting for over 50% of all cases of dementia worldwide. Currently there are no effective treatments available for AD. Plant-based medications and dietary interventions have attracted increasing research interest as an alternative strategy for the protection and treatment of AD. Thereby, this review aims to summarize different medical interventions with dietary materials such as edible medicinal plants and ways to capitalize on the therapeutic advantages of their components to provide an alternative approach to enhance their long-term pleiotropic benefits in AD. Given the established mechanisms in AD pathogenesis, we elucidate different pathophysiological changes associated with lowering the disease incidence with these mainly plant-based dietary materials, providing laboratory evidence on the feasibility and potential of dietary intervention in the prevention and treatment of AD. In particular, we highly recommend the concept of dietary intervention as an alternative or supplementary therapeutic strategy.

Download

The dietary supplement Rhodiola crenulata extract alleviates dextran sulfate sodium-induced colitis in mice through anti-inflammation, mediating gut barrier integrity and reshaping the gut microbiome

Food & Function, 2021

Rhodiola crenulata extract alleviates DSS-induced colitis in mice through anti-inflammation, medi... more

Review and Prospect of Tissue-agnostic Targeted Strategies in Anticancer Therapies

Current Topics in Medicinal Chemistry, 2021

Due to the increasing prevalence of cancer year by year, and the complexity and refractory nature... more Due to the increasing prevalence of cancer year by year, and the complexity and refractory nature of the disease itself, it is required to constantly innovate the development of new cancer treatment schemes. At the same time, the understanding of cancers has deepened, from the use of chemotherapy regimens with high toxicity and side effects, to the popularity of targeted drugs with specific targets, to precise treatments based on tumor characteristics rather than traditional anatomical location classification. In precision medicine, in the view of the specific cancer diseases and their biological characteristics, there is a great potential to develop tissue-agnostic targeted therapy with broad-spectrum anticancer significance. The present review has discussed tissue-agnostic targeted therapy based on the biological and genetic characteristics of cancers, expounded its theoretical basis and strategies for drug development. In addition, the feasible drug targets, FDA-approved drugs, a...

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Medicinal Research Reviews, 2019

Rhodiola species, belonging to the family Crassulaceae, have long been used as an adaptogen, toni... more Rhodiola species, belonging to the family Crassulaceae, have long been used as an adaptogen, tonic, antidepressant, and antistress medicine or functional food in Asia and Europe. Due to the valuable application, the growing demand of Rhodiola species has led to a rapid decrease in resource content. This review aims to summarize the integrated research progress of seven mainstream Rhodiola species. We first outline both traditional and current use of Rhodiola for the treatment of various diseases. A detailed summary and comparison of chemical, pharmacological, toxicological, and clinical studies of various Rhodiola species highlight recent scientific advances and gaps, which gives insights into the understanding of Rhodiola application and would be helpful to improve the situation of biological resources and diversities of Rhodiola plants.

Download

Hongxun Tao

Uploads

Papers by Hongxun Tao

Log In