Papers by Mohammad Sarrafzadeh
Biomass quantification and 3-D topography reconstruction of microalgal biofilms using digital image processing
Algal Research
Autotrophic granulation of hydrogen consumer denitrifiers and microalgae for nitrate removal from drinking water resources at different hydraulic retention times
Journal of Environmental Management
CHAPTER 11. Functional Nanocomposites for Removal of Contaminants of Emerging Concern
Chemistry in the Environment
Enhancing the desalination performance of forward osmosis membrane through the incorporation of green nanocrystalline cellulose and halloysite dual nanofillers
Journal of Chemical Technology & Biotechnology
Hydrogen producer microalgae in interaction with hydrogen consumer denitrifiers as a novel strategy for nitrate removal from groundwater and biomass production
Algal Research
Optimal strategies for bioremediation of nitrate-contaminated groundwater and microalgae biomass production
Environmental Science and Pollution Research
Applied Water Science
The interaction of ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB) is of co... more The interaction of ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB) is of considerable importance in nitrification process. Ecophysiological interactions between the communities of AOB and NOB were investigated by monitoring NO 2 − as the intermediate compound in an organic carbon-depleted nitrifying activated sludge fed only NH 4 + as a nitrogen source (40 mg/L). The presence of boom and bust (feast and famine) cycle successfully indicates the activity cycles of AOB and NOB through cultivation-dependent method. The maximum growth rate and yield for AOB in nitritation-dominant period were (0.67 day −1 , 0.17 gVSS gN −1) and for NOB in nitratation-dominant period were (0.71 day −1 , 0.072 gVSS gN −1). Soluble microbial products (SMP) and extracellular polymeric substances (EPS) generated by AOB were 1.2 and 1.8 mg/L, respectively, while NOB produced 0.6 mg/L of SMP and 1 mg/L of EPS. While NOB were low in utilization-associated products (UAP) (0.07 mg/L) and biomass-associated products (BAP) (0.12 mg/L), AOB were higher in UAP (0.15 mg/L) and BAP (0.3 mg/L). The continuation presence of zero C/N ratio, in either inlet ratio or net available ratio for the microbial community, can prolong and enhance nitratation process. NOB enrichment and nitratation intensification strategy through zero C/N ratio are able to reduce remarkably microbial metabolites 50% lower than conventional process and enhance nitrification efficiency in activated sludge-involved processes.
Modeling of Fermentation Process of Bacillus Thuringiensis as a Sporulating Bacterium
Chemical Product and Process Modeling
This paper intended to develop a model for predicting the progress in sporulation of Bacillus thu... more This paper intended to develop a model for predicting the progress in sporulation of Bacillus thuringiensis as an industrially important sporulating bacterium. Three distinct forms of B. thuringiensis can be observed during the fermentation process: vegetative cells, sporangia and mature spores. A mathematical model was developed for estimating the population of these three cell forms of this bacterium. A cell population balance was derived to represent the dynamic behavior of the fermentation process in a fed-batch culture. An unstructured and segregated model was used for this purpose. Experimental data at various oxygen saturation levels (0, 50 and 100 %) were used for validating the model. The model consists of a partial differential equation that describes the distribution of the cell population based on the cell age. This equation was solved by the method of lines in MATLAB. The proposed model can properly describe the cell populations and sporulation development in the mentio...
Flower-like curcumin-loaded folic acid-conjugated ZnO-MPA- βcyclodextrin nanostructures enhanced anticancer activity and cellular uptake of curcumin in breast cancer cells
Materials Science and Engineering: C
Investigating the Effect of Multiple Reference Frame Approach on the Modelling of an Oxidation Ditch
International Journal of Environmental Research
Batch adsorption/desorption for purification of scFv antibodies using nanozeolite microspheres
Microporous and Mesoporous Materials
Water management methods in food industry: Corn refinery as a case study
Journal of Food Engineering
Evaluation of Nutrient Removal and Biomass Production Through Mixotrophic, Heterotrophic, and Photoautotrophic Cultivation of Chlorella in Nitrate and Ammonium Wastewater
International Journal of Environmental Research
The impact of morphology and size of zinc oxide nanoparticles on its toxicity to the freshwater microalga, Raphidocelis subcapitata
Environmental Science and Pollution Research
Technical, economic and energy assessment of an alternative strategy for mass production of biomass and lipid from microalgae
Journal of Environmental Chemical Engineering
Effect of nitrifiers community on fouling mitigation and nitrification efficiency in a membrane bioreactor
Chemical Engineering and Processing - Process Intensification
BioImpacts : BI, 2017
Introduction: Single chain variable fragment (scFv) antibodies are reduced forms of the whole ant... more Introduction: Single chain variable fragment (scFv) antibodies are reduced forms of the whole antibodies that could be regarded as an alternative tool for diagnostic and therapeutic purposes. The optimization of processes and environmental conditions is necessary to increase the production yields and enhance the productivity. This can result in a cost-effective process and respond to the high demand for these antibodies. Methods: In this research, physical and chemical factors influencing the batch fermentation was investigated in 50 mL batch tubes using minimum media to find the optimum conditions for production of a single chain variable fragment antibody in the Escherichia coli HB2151. Experimental designs were used to screen the effective parameters and to optimize the main factors. Results: Arabinose was used instead of IPTG as a cheaper and nontoxic inducer and its optimum concentration was determined 0.1% (w/w). Induction duration time and filling volume fraction were set on ...
Nitrate removal from drinking water with a focus on biological methods: a review
Environmental Science and Pollution Research
Phosphorus optimization for simultaneous nitrate-contaminated groundwater treatment and algae biomass production using Ettlia sp
Bioresource Technology
The effects of phosphorus concentration on the cell growth, nutrient assimilation, photosynthetic... more The effects of phosphorus concentration on the cell growth, nutrient assimilation, photosynthetic parameters, and biomass recovery of Ettlia sp. were evaluated with batch experiments using groundwater, 50mg/L of N-NO3(-), and different concentrations of P-PO4(3-): 0.5, 2.5, 5, and 10mg/L. The maximum biomass productivity and phosphorus removal rate were 0.2g/L/d and 5.95mg/L/d, respectively, with the highest phosphorus concentration of 10mg/L. However, a phosphorus concentration of 5mg/L (N:P=10) was sufficient to ensure an effective nitrogen removal rate of 11mg/L/d, maximum growth rate of 0.88/d, and biomass recovery of 0.72. The appropriate hydraulic retention time was considered as 4days on a large scale to meet the effluent limitation demands of water. While nitrogen depletion had a significant effect on the photosynthetic parameters and ratio of chlorophyll a to dry cell weight during the stationary phase, the effect of phosphorus was negligible during the cultivation.
Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: Synthesis, characterization, and anticancer assessment
Materials science & engineering. C, Materials for biological applications, 2017
Inherent biocompatibility and stability of zinc oxide nanoparticles (ZnO-NPs) and their biomedica... more Inherent biocompatibility and stability of zinc oxide nanoparticles (ZnO-NPs) and their biomedical potentials make them an emerging candidate for drug delivery. The aim of this study was to develop and assess a simple procedure for surface functionalization of ZnO-NPs by 3-mercaptopropionic acid (MPA) for water-soluble curcumin delivery. Carboxyl-terminated ZnO nanoparticles were successfully made using ZnCl2 and NaOH in the presence of MPA. The functional groups were activated by 1,1'-carbonyldiimidazole (CDI) and the curcumin bonding was carried out at room temperature for 24h. The core-shell nanocomposite had a significant better solubility versus free curcumin, as characterized by XRD, FTIR, UV-Vis spectrophotometry, DLS, and TEM, p<0.005. In addition, MTT cytotoxicity assessment on MDA-MB-231 breast cancer cells revealed a drop of IC50 values from 5μg/mL to 3.3μg/mL for free curcumin and ZnO-MPA-curcumin complex, respectively. This result showed an augmented cancer-inhib...
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Papers by Mohammad Sarrafzadeh