Papers by Ali Khanlarkhani
Resistance Improvement and Sensitivity Enhancement of Cancer Therapy by a Novel Antitumor Candidate onto A2780 CP and A2780 S Cell Lines
PubMed, Oct 1, 2023
Background: To overcome cisplatin resistance, the cytotoxicity of a novel antitumor agent on two ... more Background: To overcome cisplatin resistance, the cytotoxicity of a novel antitumor agent on two ovarian cancer cell lines sensitive and resistant to cisplatin was investigated. Methods: MTT assay and flow cytometry were performed to assess the cytotoxicity of a novel water-soluble Pd (II) complex, [Pd(bpy)(pyr-dtc)]NO3 (PBPD), on cisplatin-sensitive and cisplatin-resistant ovarian cancer cell lines. Furthermore, variations in the expression of drug resistance gene cluster of differentiation 99 (CD99), signal transducer and activator of transcription 3 (STAT3), octamer-binding transcription factor 4 (OCT4), and multidrug resistance mutation 1 (MDR1) were evaluated using Real-Time PCR. Results: The IC50 values of PBPD in resistant cells were higher than those in sensitive cells. Furthermore, PBPD has a deadlier effect on sensitive cells compared to resistant cells, and the cell survival rate is reduced over time. Flow cytometry revealed that PBPD enhanced the population of living-resistant cells while driving them to apoptosis. PBPD, on the other hand, has a greater effect on the living cell population and has dramatically shifted the population toward apoptosis and necrosis in the sensitive cells. Furthermore, gene expression analysis showed that when sensitive and resistant cells were treated with cisplatin, all resistance genes increased significantly relative to the control. In contrast to OCT4, MDR1, STAT3, and CD99 resistance genes were not significantly elevated in sensitive cells treated with PBPD compared to the control. Thus, the expression of resistance genes in resistant cells treated with PBPD was lower than cisplatin. Conclusions: As a result, PBPD is a promising anticancer agent for CDDP-resistant ovarian cancer.
Microstructural Design and Mechanical Enhancement of δ-TRIP Steel Through Mo Micro-alloying and Isothermal Bainitic Transformation
Proceedings of the Institution of Mechanical Engineers. Part L, Journal of materials: design and applications/Proceedings of the Institution of Mechanical Engineers. Proceedings part L, Journal of materials: design and applications, Jan 30, 2024
Izvestiâ po Himiâ, 2019
Adaptive neuro-fuzzy inference system (ANFIS) and artificial neural network (ANN) were applied in... more Adaptive neuro-fuzzy inference system (ANFIS) and artificial neural network (ANN) were applied in modeling of methane mixed reforming in a packed bed catalytic reactor. These methods were developed by use of data collected from a methane reforming pilot plant using CO2 and steam and in process conditions near to MIDREX reforming plant in sponge Iron production. Different reaction temperatures from 700 to 1100 C with different values of carbon dioxide, steam, hydrogen, methane and carbon monoxide, were randomly selected and used to generate around 5000 data set of input-output data. Both networks achieve quite satisfying scientific results with acceptable deviations. However, it is hard to say which one is better as they have close output values but ANN marginally outperformed ANFIS in predicting the reaction outputs by varying the inputs. The prediction performances of these models are compared. The accuracies of the two models were evaluated in terms of square correlation coefficient (R 2) and mean square error (MSE).
Computational Materials Science, Sep 1, 2018
Iranian Journal of Nutrition Sciences and Food Technology, Mar 15, 2013
Antimicrobial active packaging not only protects food against environmental conditions, but also ... more Antimicrobial active packaging not only protects food against environmental conditions, but also can inhibit or reduce microorganisms growth and increase its shelf life. Because of higher surface to volume ratio, antimicrobial nanostructures are more effective against microorganisms. Amongst these antimicrobial nanostructures, nanosilver has extraordinary antimicrobial activity on abroad spectrum of microorganisms and during recent years it has attached many attentions. All the scientific articles which were published between 2000 and 2012 in Science Direct, Google scholar, Springer and Wiley databases about antimicrobial effects of silver nanoparticles on packaging of food products were reviewed. Comparing with natural components of silver, silver in nano scale has tremendous antibacterial effects and can be used in combination with wide range of packaging materials. Silver nano particles are effective against wide spectrum of gram positive and gram negative bacteria. The mechanism in which silver nano particles confer their antimicrobial effects, is mainly attributed to the oxidative stress and this effect can be achieved through both direct contact and release from packaging matrix. Silver nano particles have been used successfully in food packaging or food contact materials. They significantly reduce the growth of food spoilage and pathogenic microorganisms.
Analysis of the properties of 0.2C-4Al-1.2Mn TRIP-assisted Steel subjected to Mo micro-alloy and isothermal bainitic transformation (IBT) time
In this investigation, the results of the experiment in which two samples of TRIP-assisted steel ... more In this investigation, the results of the experiment in which two samples of TRIP-assisted steel were micro-alloyed with 0.05 and 0.30 wt.% Mo addition in combination with isothermal bainitic transformation (IBT) time parameters was analyzed and evaluated. Microstructures were studied using optical microscope (OM) and field emission scanning electron microscope (FE-SEM) equipped with an energy dispersive X-ray spectrometer (EDX). Using X-ray diffraction (XRD), the retained austenite (RA) phase volume percentage was calculated. The studied steels had a multi-phased structure including δ-ferrite as the matrix phase and α-ferrite, bainite, and RA along with some martensite. The quantity of RA and its morphology in the microstructure of the samples are key factors in achieving desirable combinations of mechanical characteristics (high strength and acceptable ductility). Yield stresses of 400-440 MPa, tensile strengths of 790-870 MPa, and elongations to failure of 24-34% were observed in...
Advanced Ceramics Progress, Nov 1, 2016
This study deals with the effect of gelatin on physical and mechanical properties of calcium phos... more This study deals with the effect of gelatin on physical and mechanical properties of calcium phosphate bone cements. The mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate (DCPA) as the cement powder was mixed with 6 wt% Na2HPO4 solution containing different amount (0, 2, 5 and 8% in w/w) of foamed gelatin as liquid phase. The physical properties were determined in the terms of setting time and macroporosity. The compressive strength was also checked before and after soaking the cements in simulated body fluid (SBF). The phase composition, microstructure and chemical groups were respectively determined using X-ray diffraction (XRD), Scanning electron microscopy (SEM) and Fourier transformation Infrared Spectroscopy (FTIR). The results showed that gelatin accelerated hydroxyapatite (HA) precipitation during setting and reduced the initial setting time from 35 min for cement without gelatin to 23 min for cement with the most amount of gelatin. Moreover, 17% (in v/v) macroporosity was induced in the cement structure using 8% solution of gelatin as the cement liquid. Gelatin addition promoted compressive strength of the set cement from 1.13 MPa (for gelatin-free cement) to 5.8 MPa.
International Journal of Environmental Science and Technology, 2017
In this study, electric arc furnace dust, waste of steelmaking industry, was selected as heteroge... more In this study, electric arc furnace dust, waste of steelmaking industry, was selected as heterogeneous Fenton catalysts for degradation of methylene blue solution. Co and Cu nanoparticles were added on EAF dust via impregnation method and characterized by ICP, XRF, XRD, BET, FESEM and HRTEM techniques. The Co/EAF catalyst displayed the best activity in removing high concentrated methylene blue solution (50 mg L-1) with initial pH, where decolorization was measured as response. Furthermore, response surface methodology with central composite design was applied to evaluate the effects of initial pH, catalyst dosage, the molar ratio of H 2 O 2 to MB and their interactive effect. According to ANOVA results, quadratic model was suggested as a significant model. This statistical technique revealed that the low-cost and magnetic recyclable Co/EAF heterogeneous Fenton catalyst had suitable catalytic activity in different reaction conditions and able to remove methylene blue completely. Finally, we studied the catalytic activity of Co/EAF as the best catalyst, in dye removing from textile factory wastewater.
Investigation of the Binding Behavior between the S-heterocyclic Aromatic Palladium(II) Complex and Human Serum Albumin: Spectroscopic Approach
Polycyclic Aromatic Compounds, 2015
The interaction of 1, 10-phenanthroline octhyldithiocarbamato palladium(II) nitrate ([Pd(Oct-dtc)... more The interaction of 1, 10-phenanthroline octhyldithiocarbamato palladium(II) nitrate ([Pd(Oct-dtc)(phen)]NO3) with human serum albumin (HSA) has been investigated by various spectroscopic techniques under physiological conditions. Here, HSA was titrated with the Pd(II) complex, followed by UV–Vis absorption spectroscopy to estimate a binding constant (Kb) and other thermodynamic parameters. The results indicate that the Pd (II) complex has a high affinity for bind HSA. Thermodynamic analysis showed that the enthalpy (ΔH°) and entropy changes (ΔS°) are positive and Gibbs free energy change (ΔG°) is negative which indicated that hydrophobic interactions played the predominant role in the binding process. Fluorescence spectroscopy were used to show the mechanism and binding parameters of this interaction. Utilizing the Stern–Volmer equation, the Pd(II) complex quenched the intrinsic fluorescence of HSA via a static quenching procedure. The specific binding distances between the tryptophan (donor) proteins and Pd(II) complex (acceptor) were estimated by Forster resonance energy transfer. The CD results also showed the conformational changes on serum albumin upon binding with the Pd(II) complex.
Effect of adding Y and Ce on corrosion behaviour of the extruded ZK60 magnesium alloy
Corrosion Engineering, Science and Technology, Sep 16, 2021
ABSTRACT The effect of rare earth elements Ce and Y addition on microstructure and corrosion beha... more ABSTRACT The effect of rare earth elements Ce and Y addition on microstructure and corrosion behaviour of an extruded ZK60 magnesium alloy was investigated. Materials characterisation was performed using a scanning electron microscope and X-ray diffraction. Corrosion behaviour of ZK60 and ZK60-3x (x = Ce, Y) alloys were evaluated using electrochemical impedance spectroscopy and potentiodynamic polarisation test. At the end of evaluations, the best corrosion performance was observed for the ZK60 base alloy, due to its microstructure consisting of larger grains and lower volume fraction of second phase particles. On the other hand, the two other alloys suffered from galvanic corrosion rising from their RE-containing particles and the more fraction of high energy grain boundaries acting as possible areas for corrosion initiation.
Electrochemical Performance of Nitrogen‐Doped Graphene/Silicene Composite as a Pseudocapacitive Anode for Lithium‐ion Battery
ChemistrySelect
Catalysts
High yield production of benzaldehyde in the solvent-free oxidation of benzyl alcohol by using gr... more High yield production of benzaldehyde in the solvent-free oxidation of benzyl alcohol by using green catalysts is highly desirable. In this work, calcium hydroxide derived from waste clamshell was used as low-cost and environmentally friendly catalyst support (CaSUP) for Pd and V nanoparticles. The physicochemical properties of the catalysts were analyzed using X-ray diffraction spectroscopy (XRD), Fourier transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET) technique, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The catalytic oxidation of benzyl alcohol to benzaldehyde was studied in a liquid phase reaction by using H2O2 as an oxidizing agent. The effects of catalyst loading, the molar ratio of hydrogen peroxide to benzyl alcohol, temperature and reaction duration were investigated. In the optimized conditions, Pd nanoparticles supported on clamshell-derived supports displayed excellent catalytic conversion (88%) and selectivity to ...
Size-tunable Ni-Cu nanoparticles using nucleation and growth control of Polyol Reduction Method
Materials Today: Proceedings
Abstract In this research, NiCu alloy nanoparticles were synthesized by polyol reduction method i... more Abstract In this research, NiCu alloy nanoparticles were synthesized by polyol reduction method in a ratio of 70:30. The particles size distribution was also studied for four different concentrations of 0.1 M, 0.2 M, 0.3 M and 0.4 M. The morphology demonstrated the particles size decreased as the concentration of metals increased. Therefore, the particles size could be effectively controlled by the amount of spices in the solvent. It was also shown that a 15-minute of ultrasonication leads the separation and uniform growth of the particles without manipulating the pH.
Journal of Laser Micro/Nanoengineering, 2012
In the present work, laser ablation as a method for texturization of a polycrystalline silicon su... more In the present work, laser ablation as a method for texturization of a polycrystalline silicon surface is studied. This involves creating a roughened surface in order to decrease reflection from the surface of a wafer. A special etching procedure was applied to remove the laser-damaged layer. The textured surface was observed using a field emission scanning electron microscope and an atomic force microscope. The surface reflectance was also measured and the results show that chemical etching needs to be applied after laser processing in order to achieve reduced reflection from a lowdefect surface.
Solvation thermodynamics of hydroxyl and carbonyl group in supercritical CO2 by Monte Carlo simulations
Chemical Physics Letters, 2008
The Helmholtz free energy of solvation (Δ slv A) of 2-propanol and acetone in supercritical CO 2 ... more The Helmholtz free energy of solvation (Δ slv A) of 2-propanol and acetone in supercritical CO 2 were calculated by expanded-ensemble method. For both solute molecules, Δ slv A is well represented by the polynomial equation of the third power of density and the density ...
Palladium nanoparticles supported on silicate-based nanohybrid material: highly active and eco-friendly catalyst for reduction of nitrobenzene at ambient conditions
Inorganic and Nano-Metal Chemistry, 2020
In this study, spent bleaching earth (SBE), a hazardous industrial waste was used as raw material... more In this study, spent bleaching earth (SBE), a hazardous industrial waste was used as raw material to synthesis carbon/silicate nanohybrid material (CSNH) as support for mono and bimetallic palladium and nickel nanoparticles. The synthesized catalysts were characterized by different techniques such as nitrogen physisorption, FTIR, XRD, FESEM, and TEM and evaluated in the reduction of nitrobenzene (NB) to aniline (AN) in a batch process at ambient conditions. The Pd/CSNH shows the highest conversion. Response surface methodology (RSM) was used for investigation of the effect of different variables. The results showed that the mole ratio of sodium borohydride to nitrobenzene has the most important impact on the conversion of nitrobenzene to aniline. In the optimal reaction conditions (20 mg Pd/CSNH and mole ratio of NaBH4/NB = 4 in 25 min), conversion, selectivity to aniline and yield of 100% were obtained at room temperature.
Partial Acetylene Hydrogenation Over Commercial PD-AG/Α-AL2O3 Catalyst Promoted by Ionic Liquid
Nanowires Fine Tunable Fabrication by Varying the Concentration Ratios, the Etchant and the Plating Spices in Metal-Assisted Chemical Etching of Silicon Wafer
Pseudomorphism is known as a suitable technique for producing mesoscale pore in silica powders al... more Pseudomorphism is known as a suitable technique for producing mesoscale pore in silica powders along with preservation of particle morphology. Herein, silica discs with several millimeter dimensions have been prepared using the mentioned method. This method has been utilized through application of pseudomorphism reaction of preshaped bodies by immersion in a solution containing surfactant and swelling reagents. The pseudomorphism reactions were performed in time and temperature controlled conditions. Mesoporous silica disc, because of its large surface area, has been considered here as catalyst support in methane steam reforming. The silica support has been utilized in production of Nisilica catalyst through impregnation method. The physical properties of the synthesized mesoporous support and nanocatalysts have been characterized by nitrogen adsorption-desorption surface measurement (BET-BJH method) and Archemideous immersion analysis as well as field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), inductively coupled plasma (ICP) analyses techniques. Investigation on catalytic behavior of prepared samples in steam reforming of methane showed that Ni/S1 sample has superior catalytic activity in comparison with Ni/S0 sample (Methane conversion of 85% and hydrogen yields more than 60% at 620 °C).
Easy and economical nanocasting method for preparation of carbon adsorbent using low-cost precursors in the presence of a natural zeolite as template
Micro & Nano Letters
Carbon adsorbents have been prepared through an economical method including nanocasting of sucros... more Carbon adsorbents have been prepared through an economical method including nanocasting of sucrose in naturally occurring clinoptinolith-type zeolite from Semnan-Iran. Carbonisation of hybrid material containing nanocasted sucrose in natural zeolite was performed in an atmos-phere controlled tube furnace using N 2 as inert gas. Two different processes, namely acid wash and KOH molten salt methods, were utilised for template removal and carbon activation. The resultant activated carbon samples were characterised by X-ray diffractometery, small angle X-ray scattering and scanning electron microscopy techniques. Based on these techniques the KOH molten salt procedure is selected as the best method for both leaching of the zeolite template and activation of the final product. The surface area and porosity of samples were also deter-mined by the conventional nitrogen porosimetry method using the Brunaure-Emmet-Teller and Barrett-Joyner-Halenda models. The selected samples were successful...
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Papers by Ali Khanlarkhani