nasser khalil

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Physicochemical studies on starch isolated from Egyptian wheat cultivars

African Journal of Biological Sciences, 2018

In the current study, starch was isolated from two Egyptian wheat cultivars, namely, Wheat Durum ... more In the current study, starch was isolated from two Egyptian wheat cultivars, namely, Wheat Durum BeniSuef 1 and Bread Wheat Misr 1. The isolated starches were subjected to versatile physicochemical study, comprising, proximate analyses (contents of ash, moisture, protein, total carbohydrates), total organic matter (TOM), total organic carbon (TOC), undesired elemental content (chromium, nickel, arsenic, lead and cadmium), nutritive elemental content (sodium, potassium, phosphorus, magnesium, calcium, manganese, iron, cobalt, copper, zinc and selenium), other elements (molybdenum, tin and antimony), amylose, amylopectin, pH value, water binding capacity (WBC), total hydrolysable carbohydrates, swelling power and solubility. Spectral studies including Fourier transform infrared (FT-IR) and X-Ray diffraction pattern of the isolated starches were thoroughly envisaged.

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Physicochemical Properties of Starches Isolated from Two Common Egyptian Wheat Cultivars

Starch is a major component of versatile cereals, tubers and food products and it plays an import... more Starch is a major component of versatile cereals, tubers and food products and it plays an important role in the appearance, structure and quality of foods due to its pasting properties, retogardation and other valuable physicochemical properties. To date, there is no single published report studying the physicochemical properties of starches isolated from different Egyptian crop cultivars. As wheat is considered one of the oldest, most extensively cultivated, and higher nutritional value and strategic crops in the world and in Egypt, the current study deals with physicochemical properties of starch isolated from two common Egyptian wheat cultivars, namely, Wheat Durum Beni Suef 1 and Bread Wheat Misr 1. The isolated starches were subjected to versatile physicochemical study, comprising, proximate analyses (contents of ash, moisture, protein, total carbohydrates), total organic matter (TOM), total organic carbon (TOC), undesired elemental content (chromium, nickel, arsenic, lead and...

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Stress response and antioxidant profile in Egyptian cows naturally infected with lumpy skin disease

Journal of Multidisciplinary Sciences, 2020

Lumpy skin disease (LSD) is a severe disease of cattle that causes a broad spectrum of economic l... more Lumpy skin disease (LSD) is a severe disease of cattle that causes a broad spectrum of economic losses. The purpose of this study is to shed light on some physiological changes that may occur in the infected Egyptian local cows, including the primary and secondary stress responses besides the antioxidant profile. Two groups of Egyptian adult cows were used in the present study. The first group (control group) consisted of 10 clinically healthy cows, while the other one (infected group) consisted of 7 naturally infected LSD cases subjected to routine clinical examination. The clinical investigation revealed skin lesions passing through different progressive stages, starting from the appearance of nodules until the formation of deep scars. LSD was associated with a well-noted stress response, as exemplified by hyperglycemia, hyperlactatemia, and increases in serum cortisol, urea, and creatinine levels. Marked depletion in serum superoxide dismutase and catalase activities, vitamin E, malondialdehyde, and total peroxide levels were observed in the LSD challenged cows. These findings indicated the ability of LSD to induce stress reactivity and disturb the redox balance, and therefore the application of stress-management strategies and administration of dietary antioxidants is highly recommended to enhance the health status of infected animals. This study paves the road towards other works investigating the differential response of oxidative stress biomarkers to this disease according to its severity and stages and choosing the best antioxidant supplements.

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Antimicrobial Evaluation and Structure-Activity Relationship (SAR) of Some 1,ω-bis[4-Carboxy/Methoxycarbonyl/(Hydrazinecarbonyl)/Phenoxy]Alkanes

Annual Research & Review in Biology, 2017

This work was carried out in collaboration between both authors. Author NSAMK designed the study,... more This work was carried out in collaboration between both authors. Author NSAMK designed the study, managed literature searches, performed and managed the chemical synthesis, wrote the protocol and wrote the first draft of the manuscript. Author NMM managed the elemental analyses, spectral data (IR data, 1 HNMR data) and antimicrobial evaluation of the study. Both authors read and approved the final manuscript.

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Estimation of the Modulatory Roles of Thieno [2,3-c] Pyrazole Compounds Versus the Toxicity of 4-Nonylphenol in African Catfish (Clarias gariepinus)

International Journal of Biochemistry Research & Review, 2016

The endocrine disrupting substances represent major challenge to aquaculture and the most widespr... more The endocrine disrupting substances represent major challenge to aquaculture and the most widespread one is 4-nonylphenol (4-NP). Pyrazole possess an interesting broad spectrum of pharmacological actions. Therefore, this study was designed to investigate the therapeutic potential of five novel thieno [2,3-c] pyrazole compounds in African catfish (Clarias gariepinus) on the hematotoxic and electrolyte disruptor influences of 4-NP. The hemato-electrolyte disturbance induced by 4-NP was well proved by many examined endpoints. On the other hand, thienopyrazole compounds exhibited the ability to modulate the previous toxicological impact by different levels based on the modification in structures and properties. This study provided insight into the endless therapeutic treasures of newly synthesized complexes, and a driving force for its application on the other clinically relevant problems in fish.

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Antidiabetic and Antioxidant Impacts of Desert Date (Balanites aegyptiaca) and Parsley (Petroselinum sativum) Aqueous Extracts: Lessons from Experimental Rats

Journal of Diabetes Research, 2016

Medicinal plants are effective in controlling plasma glucose level with minimal side effects and ... more Medicinal plants are effective in controlling plasma glucose level with minimal side effects and are commonly used in developing countries as an alternative therapy for the treatment of type 1 diabetes mellitus. The aim of this study is to evaluate the potential antidiabetic and antioxidant impacts ofBalanites aegyptiacaandPetroselinum sativumextracts on streptozotocin-induced diabetic and normal rats. The influences of these extracts on body weight, plasma glucose, insulin, total antioxidant capacity (TAC), malondialdehyde (MDA) levels, and liver-pyruvate kinase (L-PK) levels were assessed. Furthermore, the weight and histomorphological changes of the pancreas were studied in the different experimental groups. The herbal preparations significantly reduced the mean plasma glucose and MDA levels and significantly increased the mean plasma insulin, L-PK, and TAC levels in the treated diabetic groups compared to the diabetic control group. An obvious increase in the weight of the pancr...

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Comparative studies for selective deprotection of the N-arylideneamino moiety from heterocyclic amides: kinetic and theoretical studies. Part 2

Tetrahedron, 2006

Benzylideneamino-1,2,4-triazine-3,5(2H,4H)-diones (2-5), 6-styryl-1,2,4-triazine-3,5(2H,4H)-dione... more Benzylideneamino-1,2,4-triazine-3,5(2H,4H)-diones (2-5), 6-styryl-1,2,4-triazine-3,5(2H,4H)-dione (6), and 6-styryl-2,3-dihydro-3-thioxo-1,2,4-triazin-5(4H)-one (7) were synthesized and pyrolyzed in the gas phase. The kinetic effect of changing the substituent on the triazine ring from hydrogen to methyl, phenyl, and styryl was measured. Analyses of the pyrolyzates of 2-5 showed the elimination products to be benzonitrile and the triazine fragment, while the pyrolyzates of 6 and 7 reveal the formation of cis-and trans-cinnamonitriles. Theoretical study of the pyrolysis reactions of 2-5 using an ab initio SCF method was investigated.

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Efficient route to 20–32 membered macrocyclic crown diamides via ring closing metathesis

Tetrahedron, 2004

RCM of the appropriate bis-allyloxyacetanilides and bis-o-allyloxyphenoxyacetanilides led to an e... more

Psychoanalysis and

Rocky Mountain Review of Language and Literature, 1991

Analysis of the pore structure of activated carbons produced from paper mill sludge using small angle neutron scattering data

A novel, cost-effective, and environmentally benign process was developed to produce highly effic... more A novel, cost-effective, and environmentally benign process was developed to produce highly efficient carbon-based adsorbents (CBAs) from paper mill sludge. The production process required chemical activation of sludge using zinc chloride and pyrolysis at 750 C in Nâ gas. The produced CBAs were characterized according to their surface area and pore size distribution using Nâ-BET adsorption isotherm data. Further characterization of the surface and pore structure was conducted using a unified exponential/power law approach applied to small angle neutron scattering (SANS) data. The structural features analyzed by SANS revealed the dependence of porosity with zinc chloride concentration. The presence of inaccessible pores was also determined by contrast-match experiments.

Synthesis of Some Novel 6‐Benzyl(or Substituted Benzyl)‐2‐β‐ d ‐Glucopyranosyl‐1,2,4‐Triazolo[4,3‐ b ][1,2,4]Triazines as Potential Antimicrobial Chemotherapeutics

Nucleosides, Nucleotides and Nucleic Acids, 2004

Nucleic acids U 0700 Synthesis of Some Novel 6-Benzyl(or Substituted Benzyl)-2-β-D-glucopyranosyl... more Nucleic acids U 0700 Synthesis of Some Novel 6-Benzyl(or Substituted Benzyl)-2-β-D-glucopyranosyl-1,2,4-triazolo[4,3-b][1,2,4]triazines as Potential Antimicrobial Chemotherapeutics. -The synthesis of new N-glycosides (III) (formed as pyridinium salts) and some chemical transformations leading to new functionalities are described. Derivatives (IIIb) and (IIIc) show moderate antimicrobial activity. -(KHALIL*, N. S. A.

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Selective Synthesis and Reactions of 6-Substituted- 2-β-galactosyl-1,2,4-triazines of Potential Anticancer Activity

Nucleosides, Nucleotides and Nucleic Acids, 2003

Nucleic acids U 0700 Selective Synthesis and Reactions of 6-Substituted-2-β-galactosyl-1,2,4-tria... more Nucleic acids U 0700 Selective Synthesis and Reactions of 6-Substituted-2-β-galactosyl-1,2,4-triazines of Potential Anticancer Activity.-Following a direct glycosidation protocol of 4-aminothioxotriazinones and 4-arylthioxotriazinones, new 2-galactopyranosyl derivatives of 6-substituted thioxotriazinones are selectively synthesized. Twelve selected compounds are tested for their human anticancer activity using an in vitro model through a 3-cell line, one dose primary anticancer assay consisting of MCF7 (breast), NCl-H460 (lung) and SF-268 (CNS). Triazine derivative (Va) reveals activity against MCF7 and SF-268 cell lines.

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Synthesis of Some N -Galactosides of 3-Aryl-5-benzyl (or Substituted Benzyl)-1,2,4-triazin-6(1 H )-/ones or Thiones of Expected Biological Activity

Nucleosides, Nucleotides and Nucleic Acids, 2003

The 1-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-3-aryl-5-benzyl (or substituted benzyl)-1,... more The 1-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-3-aryl-5-benzyl (or substituted benzyl)-1,2,4-triazin-6(1H)-/ones or thiones were prepared via galactosidation of 3-aryl-5-benzyl (or substituted benzyl)-1,2,4-triazin-6(1H)-/ones or thiones with 2,3,4,6-tetra-O-acetyl-alpha-D-galactopyranosyl bromide. The structure of the new galactosyl derivatives was based on both spectroscopic and chemical evidences.

Synthesis of Some New 2-α- L -Arabinopyranosyl-1,2,4-triazines as Potential Antitumor Chemotherapeutics

Nucleosides, Nucleotides and Nucleic Acids, 2003

Synthetic routes towards different 2-alpha-L-arabinopyranosyl-3-thioxo-2,3-dihydro-1,2,4-triazin-... more

Synthesis of Some New 1,3/ or 1,4-Bis(Glucopyranosyl-1,2,4-Triazol-5-Ylthio)Propanes/ or Butanes as Potential Antimicrobial Agents

Nucleosides, Nucleotides and Nucleic Acids, 2005

Glucosidation of the appropriate 1,3 or 1,4-bis(4-amino or arylideneamino-2,4-dihydro-3-thioxo-3H... more Glucosidation of the appropriate 1,3 or 1,4-bis(4-amino or arylideneamino-2,4-dihydro-3-thioxo-3H-1,2,4-triazol-5-ylthio)propanes or butanes with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide followed by chromatographic separation gave the corresponding N-, S-, and N,S-bis(glucosides). Chemical transformation leading to new functionalities has been achieved. Antimicrobial screening of 10 selected compounds resulted in their activity against Aspergillus fumigatus, Penicillium italicum, Syncephalastrum racemosum, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli.

Synthesis of Novel α- l -Arabinopyranosides of β-Lactams with Potential Antimicrobial Activity

Nucleosides, Nucleotides and Nucleic Acids, 2005

Synthetic routes toward the synthesis of some novel 1-(2,3,4-tri-O-acetyl-alpha-L-arabinopyranosy... more

Synthesis of Some Novel N-Ribosyl-1,2,4-Triazin-6(1H)-/Ones or Thiones as Potential Antibacterial and Antifungal Chemotherapeutics

Nucleosides, Nucleotides and Nucleic Acids, 2005

Nucleic acids U 0700 Synthesis of Some Novel N-Ribosyl-1,2,4-triazin-6(1H)-/ones or Thiones as Po... more Nucleic acids U 0700 Synthesis of Some Novel N-Ribosyl-1,2,4-triazin-6(1H)-/ones or Thiones as Potential Antibacterial and Antifungal Chemotherapeutics.-Ribosylation of triazinones or triazinthiones (II) yields the corresponding new triazine nucleosides following a simplified one-step/one-pot nucleoside synthesis. Compounds (IVb)-(IVd) are tested for antimicrobial activity. Nucleoside (IVd) reveals the greatest inhibitory effect against one or more type of microorganisms.

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Synthesis of Some Novel N-Ribosyl-1,2,4-Triazin-6(1H)-/Ones or Thiones as Potential Antibacterial and Antifungal Chemotherapeutics

Nucleosides, Nucleotides and Nucleic Acids, 2005

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First Synthesis And Antimicrobial Activity OfN- andS-α-L-Arabinopyranosyl-1,2,4-Triazoles

Nucleosides, Nucleotides and Nucleic Acids, 2007

Nucleic acids U 0700 First Synthesis and Antimicrobial Activity of N-and S-α-L-Arabinopyranosyl-1... more Nucleic acids U 0700 First Synthesis and Antimicrobial Activity of N-and S-α-L-Arabinopyranosyl-1,2,4-triazoles.-The unusually functionalized Sand N-α-L-arabinosyltriazoles (VI) and (VII) are synthesized as potential antimicrobial agents expanding the utility of both base-modified and sugar-modified nucleosides. The title compounds can be prepared via condensation of (III) and (IV) with aryl aldehydes (V) or by arabinosidation of arylideneaminotriazoles (VIII). Compounds (VId) and (VIId) are screened for their antifungal and antibacterial activities. (VIId) displays higher inhibitory effects than its regioisomer (VId).

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Novel Simple Efficient Synthetic Approach Toward 6-Substituted-2H-[1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazole-3-Thiones and First Synthesis and Biological Evaluation ofN-andS-β-D-Glucosides of the[1,2,4]Triazolo [3,4-b][1,3,4]Thiadiazole Ring System

Nucleosides, Nucleotides and Nucleic Acids, 2007

Nucleic acids U 0700 Novel Simple Efficient Synthetic Approach Toward 6-Substituted-2H-[1,2,4]tri... more Nucleic acids U 0700 Novel Simple Efficient Synthetic Approach Toward 6-Substituted-2H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-3-thiones and First Synthesis and Biological Evaluation of N-and S-β-D-Glucosides of the [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole Ring System.-The novel procedure for the synthesis of triazolothiadiazolethiones (III) enables an easy access for the first synthesis of Sand N-β-D-glucosides of the title ring system, (V) and (VI). Compounds (V) are alternatively synthesized in excellent yields via glucosidation of (I) affording (VII) as the sole product which in turn undergoes ring closure with aromatic acids or acid chloride. Compounds (Vd) and (VId) are screened for their antifungal and antibacterial activities; (Vd) shows inhibitory effects against more test organisms than (VId).

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