Papers by mohamed elgendy
SARS-CoV-2 infection associated severe dilated cardiomyopathy in a 4-week-old infant
IDCases
Twelfth IEEE International Workshop on Quality of Service, 2004. IWQOS 2004.
Paving the first mile of Quality-of-Service (QoS) support has become essential for full deploymen... more Paving the first mile of Quality-of-Service (QoS) support has become essential for full deployment and utilization of QoS proposals in the Internet. Most of existing efforts have been made to provide network services and control without paying much attention to how applications can use these services. In this paper we design and implement a two-tier architecture, called QoS Gateway (QoSGW), that acts as an interface between application QoS requirements and network-provided QoS capabilities. The QoSGW is to support small embedded network devices that rely on network-provided QoS. Our architecture, in its full version, is composed of two key components: (i) an agent that resides on the end-host and provides an adequate interface for QoS-dependent applications, and (ii) a QoS manager that provides an interface to network services for the agents. Using these two components enhances generality and scalability in providing QoS support for Internet applications and enddevices. The QoSGW is intended to promote QoS deployment and facilitate construction of QoS-aware access networks.
SARS-CoV-2 infection in mortuary and cemetery workers
International Journal of Infectious Diseases
Port-Said Engineering Research Journal
The seepage problems from open channels constitute one of the major problems facing ministry of w... more The seepage problems from open channels constitute one of the major problems facing ministry of water recourses and irrigation. Many solutions are suggested to solve the problem of seepage from channels, some solution by covering the bottom of the channel with concrete or asphalt, other solution by the use of sheet piles. The current study aims to control the seepage losses by using clay core to decrease the seepage amount. The clay core can decrease the seepage rate by increasing the length of seepage line. Since the seepage lines are inclined, the most effective position of clay core has been determined by studying the effect of vertical clay core with different penetration depths in the soil and different head difference. Similarly studying the seepage rate for different positions of the core clay and constant pressure difference (ΔH) has been evaluated.
Egyptian Journal of Histology
A phase I study of CX-4945 administered orally twice daily to patients with advanced basal cell carcinoma
Journal of Clinical Oncology
TPS10080 Background: Smoothened inhibitors (SMOi) targeting the Hedgehog (Hh) pathway have been a... more TPS10080 Background: Smoothened inhibitors (SMOi) targeting the Hedgehog (Hh) pathway have been approved for the treatment of patients with locally advanced Basal Cell Carcinoma (laBCC) or metastatic BCC (mBCC). Unfortunately, resistance against SMO inhibitors (SMOi) can develop. Targeting the signaling cascade downstream of SMO, in this case via a novel small molecule inhibitor, could obviate this issue. Casein Kinase 2 (CK2) affects the terminal component of the Hh signaling pathway by promoting Gli2 stability and Gli2’s interaction with target genes. Given the interplay between CK2 and GLI-2 and the importance of Hh signaling activation, CX-4945, a potent CK2 inhibitor, may provide benefits for the BCC patients with resistance or intolerance to SMOi. Methods: A phase I trial (NCT03897036) to explore various treatment durations of CX-4945 was designed for patients with laBCC or mBCC; with endpoints include safety (CTCAE v5) and objective response rate by RECIST 1.0 for mBCC and co...
Inhibition of the Histone Demethylase LSD1 Combined with Caloric Restriction or IGF1/Insulin Inhibition Leads to Durable Responses in a Preclinical Model of Acute Myeloid Leukemia
Blood
Introduction. There is increasing interest in therapeutic modulation of metabolic pathways in can... more Introduction. There is increasing interest in therapeutic modulation of metabolic pathways in cancer. Tumor cells preferentially use aerobic glycolysis to meet their energetic demands. However, glycolysis inhibition alone is unable to bring durable responses because of limited therapeutic index and because of previously underappreciated metabolic adaptability in tumor cells, which can switch to alternative substrate usage when specific nutrients are limiting. The molecular basis of metabolic adaptation is poorly understood. Recently, the histone demethylase LSD1 (Lysine-Specific Demethylase 1) has been implicated in the control of oxidative phosphorylation (OXPHOS) in adipocytes through its interaction with NRF1 (Nuclear Respiratory Factor 1), a master regulator of metabolic gene transcription (1). We hypothesized that LSD1 could regulate metabolic adaptability and be a therapeutic target upon metabolic modulation through Caloric Restriction (CR) in Acute Myeloid Leukaemia (AML) and...
Port-Said Engineering Research Journal
Due to the short history of the Deep Mixing Method (DMM) in Egyptthere is limited data on the imp... more Due to the short history of the Deep Mixing Method (DMM) in Egyptthere is limited data on the improved properties of Port Said clay. In addition, there are enormous amounts of by-products fro m cement, marb le and limestone industries that need to be employed instead of being environmentally harmfu l materials.This paper aims to bridge the gap of limited data about the effectiveness of dry mixing method to improve strength properties of Port Saidclay using common binders, cement and lime. In addition, the effectiveness of using cement waste, limestone waste and marble powder to partially or fully rep lace cement and limein the dry mixing method was examined.To achieve this purpose, a large number of unconfined compression testsand limited number of triaxial tests were performed. Different binder"s contents and different mixing proportions between binders were blended to prepare specimens using soils representtwo different layers ofSouth Port Said clay. The results of testing specimens afterdifferent curing time showed that dry mixing method can effectively improve strength and stiffness of Port Said clay.It was also concluded that cement waste can partially or fully rep lace cement and lime to improve Port Said clay by dry mixing method whilewith marble powder and limestone waste can partially be used with less effectiveness.
Port-Said Engineering Research Journal
Modelling the interaction between piled raft and shear wall frame structure has not attracted man... more Modelling the interaction between piled raft and shear wall frame structure has not attracted many researchers in last decades. Herein, a 3-D continuum model of piled raft and shear wall frame structure was introduced. That model was incorporated into developed software in order to study the behaviour of shear wall against earthquakes. The soft soil type of Port-Said was examined in this study to get practical solutions for soft soil problem in such cases. Different parametric cases were presented to reflect the effect of the position as well as stiffness of shear walls on deformations, stresses, and mo ments and drift ratios. Factors were considered of shear wall geometry and stiffness to study the behaviour of shear walls with piled raft over soft soil. So il was simu lated by elast ic plastic model, wh ile FEM was used to model piled raft and shear walls. ASTN3 wh ich was developed by the author was used here to analyze different cases and numerical results and conclusions were introduced.
Port-Said Engineering Research Journal
One of the most important factors in the process of jack-up rig installation is the good expectat... more One of the most important factors in the process of jack-up rig installation is the good expectation of the amount of spud-can penetration into soil layers under the varying loads. It is important to insert the spud-can through soil layers up to the expected stability depth during the installation process to guarantee enough soil stability reaction. The Press-Replace Technique (PRT), which is considered a kind of small-deformation nonlinear-material finite-element analysis, is applied in this paper to track the full load-penetration response of a spud-can in double-layered soil. A parametric study was carried out by using Plaxis 2D Vr.8.6 to evaluate the effect of the strength properties of soil on the Punchthrough phenomenon and the bearing capacity of soil spud-can system by applying the Press Replace Technique (PRT). This study is also concerned with the penetration of a circular spud-can in stiff clay over either soft clay or loose sand soil. Among the considered properties of the soil, it was demonstrated that the undrained shear strength of top stiff clay layer is the most important parameter that affects the penetration response of spud-can in this case, where the properties of the lower soft clay layer do not have major effect.
Port-Said Engineering Research Journal
During the last two decades, new container ship generations had come into service, as a result of... more During the last two decades, new container ship generations had come into service, as a result of the huge growth of container trade. New container ships with larger dimensions may lead to the need to develop many of container terminals by either just deepening in front of quay walls or by deepening and replacing existing quay cranes with ones of higher capacities. In Port Said area there are several ports that need to keep pace with the tremendous progress in ship sizes. One of these ports is the Port Said East Port container terminal located on the Mediterranean Sea to the north of Egypt. The diaphragm wall which services as a berthing structure in this port is one of the deepest diaphragm wall structures built in soft clay, 62.5m deep below lowest astronomical tide (LAT). The existing water depth in the front of the quay wall is 18 m. This paper describes a finite element approach for analyzing the behavior of the quay wall under development scenarios using static calculation only. The finite element programs PLAXIS 2D Version 8.2 and PLAXIS 3D Version 1.6 have been used to analyze the performance of the structural elements, soil and the overall stability under deepening and the increase of crane wheel loads to accommodate the expected future ship sizes. The results showed that the diaphragm quay wall can resist safely 4 m deepening in front of the quay wall considering the existing crane loads. While, the results showed that width of cracks limitation will restrict increasing quay cranes loads.
Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
Cancer Cell
World Journal of Cardiovascular Diseases
Background: Acute myocardial infarction is a leading cause of death worldwide nowadays and treatm... more Background: Acute myocardial infarction is a leading cause of death worldwide nowadays and treatment of choice is primary percutaneous coronary intervention (PCI). No reflow is a complication that increases mortality and morbidity post intervention and one of its predictors is platelet lymphocyte ratio. Aim of Study: To assess relation between admission platelet to lymphocyte ratio (PLR) and angiographic reflow after primary PCI in acute ST elevation myocardial infarction (STEMI). Patients and Methods: This is a prospective study that was conducted from May 2017 to May 2018 at Cardiology Department, Menoufia University Hospital. Sixty patients presented with ST-elevation myocardial infarction who were eligible for primary PCI were enrolled in the study. According to TIMI flow post intervention, patients were arranged into 2 groups: Group 1 (Normal Reflow) included thirty patients with post intervention TIMI flow III and Group 2 (NO Reflow) included thirty patients with post intervention TIMI flow (0, I, II). Comparison between both groups was done regarding platelet lymphocyte ratio (PLR). Result: PLR was significantly higher in patients with coronary no reflow than in patients with normal reflow with a P-value of <0.001. Also, timing interval between onset of chest pain to time of intervention and thrombus grading was significantly higher in patients with no reflow than in patients with normal reflow. Conclusion: Pre-intervention PLR is an independent predictor of slow flow/no reflow following PPCI in patient with acute STEMI.
Cureus
Coronary artery dissection is a rare and life-threatening condition. It can result in thrombus fo... more Coronary artery dissection is a rare and life-threatening condition. It can result in thrombus formation and coronary occlusion with subsequent acute coronary syndrome, ventricular arrhythmia, and death. Traumatic coronary artery dissection is an especially rare type of dissection and usually happens in the setting of a high-speed motor vehicle collision. Early recognition and treatment are crucial for survival in patients suffering from this pathology. We present a case of a patient who developed right coronary artery dissection following a motor vehicle collision that was subsequently managed by coronary angiogram and revascularization.
International Journal of Cancer
Sunitinib is one of the most widely used targeted therapeutics for renal cell carcinoma (RCC), bu... more Sunitinib is one of the most widely used targeted therapeutics for renal cell carcinoma (RCC), but acquired resistance against targeted therapies remains a major clinical challenge. To dissect mechanisms of acquired resistance and unravel reliable predictive biomarkers for sunitinib in RCC, we sequenced the exons of 409 tumor-suppressor genes and oncogenes in paired tumor samples from an RCC patient, obtained at baseline and after development of acquired resistance to sunitinib. From newly arising mutations, we selected, using in silico prediction models, six predicted to be deleterious, located in G6PD, LRP1B, SETD2, TET2, SYNE1, and DCC. Consistently, immunoblotting analysis of lysates derived from sunitinib-desensitized RCC cells and their parental counterparts showed marked differences in the levels and expression pattern of the proteins encoded by these genes. Our further analysis demonstrates essential roles for these proteins in mediating sunitinib cytotoxicity and shows that their loss of function renders tumor cells resistant to sunitinib in vitro and in vivo. Finally, sunitinib resistance induced by continuous exposure or by inhibition of the six proteins was overcome by treatment with cabozantinib or a low-dose combination of lenvatinib and everolimus. Collectively, our results unravel novel markers of acquired resistance to sunitinib and clinically relevant approaches for overcoming this resistance in RCC.
Identification of the photovoltaic model parameters using the crow search algorithm
The Journal of Engineering
Frontiers in pharmacology, 2018
In the original article, acknowledgment of funding by the Mahlke-Obermann Stiftung and the Europe... more In the original article, acknowledgment of funding by the Mahlke-Obermann Stiftung and the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no. 609431/INDICAR (Interdisciplinary Cancer Research) Postdoctoral Fellowship Programme of the University of Vienna to ME was missing. The authors apologize for this oversight. This error does not change the scientific conclusions of the article in any way. The original article has been updated.
Frontiers in pharmacology, 2017
Sunitinib, a multityrosine kinase inhibitor, is currently the standard first-line therapy in meta... more Sunitinib, a multityrosine kinase inhibitor, is currently the standard first-line therapy in metastatic renal cell carcinoma (mRCC) and is also used in treating patients with pancreatic neuroendocrine and imatinib-resistant gastrointestinal stromal tumors (GIST). Nevertheless, most patients eventually relapse secondary to intrinsic or acquired sunitinib resistance. Autophagy has been reported to contribute to both chemo-sensitivity and -resistance. However, over the last few years, controversial regulatory effects of sunitinib on autophagy have been reported. Since gaining insights into the underlying molecular insights and clinical implications is indispensible for achieving optimum therapeutic response, this minireview article sheds light on the role of a network of prosurvival signaling pathways recently identified as key mediators of sunitinib resistance with established and emerging functions as autophagy regulators. Furthermore, we underscore putative prognostic biomarkers of ...
Science Proceedings
Chloroquine-a clinically available and cheap antimalarial drug-might have potential usefulness as... more Chloroquine-a clinically available and cheap antimalarial drug-might have potential usefulness as adjuvant chemotherapy when combined with sunitinib, reports a preclinical study recently published online in Chemico-biological Interactions. Just few years after its FDA approval to be used in imatinib resistant gastrointestinal tumor, renal carcinoma and pancreatic neuroendocrine tumor, light has been shed on the limited clinical efficacy of sunitinib as well as rapid development of resistant cells when used as monotherapy. Abdel-Aziz and her colleagues now showed that chloroquine augments sunitinib anticancer activity in vitro human cancer cell lines of breast, colorectal, cervical, laryngeal, liver and prostate origin and in vivo in murine Ehrlich ascites carcinoma tumor model. Furthermore, chloroquine interrupted autophagic flux which was induced by sunitinib. They noted that chloroquine when combined with sunitinib showed further activation of apoptosis in cancer cells. The observed synergy was associated with increased nitric oxide and reduced reactive oxygen species levels. The present findings warrant further studies to explore the safety profile of the combination regimen and its clinical usefulness in vivo and then in controlled clinical trials.
Proceedings of the IEEE
The past few years have witnessed the emergence of many real-time networked applications on the I... more The past few years have witnessed the emergence of many real-time networked applications on the Internet. These types of applications require special support from the underlying network such as reliability, timeliness, and guaranteed delivery, as well as different levels of service quality. Unfortunately, this support is not available within the current "best-effort" Internet architecture. In this paper, we review several mechanisms and frameworks proposed to provide network-and application-level quality of service (QoS) in the next-generation Internet. We first discuss the QoS requirements of many of the above-mentioned real-time applications, and then we categorize them according to the required service levels. We also describe the various building blocks often used in QoS approaches. We briefly present asynchronous transfer mode (ATM) and Internet Protocol precedence. Then, we present and compare two service architectures recently adopted by the Internet Engineering Task Force, called integrated services (IntServ) and differentiated services (DiffServ), for providing per-flow and aggregated-flow service guarantees, respectively. We focus on DiffServ because it is a candidate QoS framework to be used in next-generation Internet along with multiprotocol label switching and traffic engineering. We also examine several operational and research issues that need to be resolved before such frameworks can be put in practice. Keywords-Differentiated services (DiffServ), integrated services (IntServ), quality of service (QoS), real-time applications, scalability. I. INTERNET QUALITY OF SERVICE Real-time networked applications depend on network parameters such as bandwidth, delay, jitter (interpacket delay variation), and loss for their correct operation. The degree of tolerance or sensitivity to each of these parameters varies
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Papers by mohamed elgendy