Papers by larry augsburger
Pharmaceutical Dosage Forms: Tablets Third Edition Volume 2: Rational Design and Formulation
Lubricants, Glidants, and Antiadherents
Practical considerations in the scale-up of powder-filled hard shell capsule formulations
Mechanical Strength of Tablets
Approaches for Improving Bioavailability of Poorly Soluble Drugs
Advances in Capsule Formulation Development and Technology
CRC Press eBooks, Oct 30, 2017
Pharmaceutical drug delivery embraces a range of delivery carriers and constructs that have dimen... more Pharmaceutical drug delivery embraces a range of delivery carriers and constructs that have dimensions ranging from several nanometers (nanotechnology) to numerous millimeters (conventional dosage forms, i.e., pellets, tablets, and capsules). Such delivery systems spawn a whole array of assemblies for delivery of highly potent active drugs through different routes of administrations to numerous sites and targets in the human or animal body to treat disease conditions. Such delivery types and carrier systems, with their relative sizes together with some molecules and bacterial cells, are shown in Figure 12.1.
| Pharmaceutical Dosage Forms - Tablets | Taylor & Francis Group
Superdisintegrants: Characterization and Function
Tooling for Pharmaceutical Processing
Direct Compression and the Role of Filler-binders
CRC Press eBooks, Apr 19, 2016
Formulation and Characterization of a Compacted Multiparticulate System for Modified Release of Water-Soluble Drugs—Part II Theophylline and Cimetidine
Drug Development and Industrial Pharmacy, May 1, 2009
Magnesium Lauryl Sulfate in Tableting: Effect on Ejection Force and Compressibility
Journal of Pharmaceutical Sciences, Feb 1, 1974
Abstract The effect of magnesium lauryl sulfate on tablet ejection force and filler compressibili... more Abstract The effect of magnesium lauryl sulfate on tablet ejection force and filler compressibility was evaluated and compared to magnesium stearate in four direct compression fillers (micro- crystalline cellulose, compressible starch, spray-dried lactose, and direct compression sucrose) and a typical wet granulation (terra alba) using a rotary tablet press instrumented to monitor ejection and compression forces. Generally, higher concentrations of magnesium lauryl sulfate were required to produce ejection forces similar to those obtained with magnesium stearate. However, batches employing magnesium stearate were generally less compressible than batches employing magnesium lauryl sulfate at levels sufficient to produce similar or lower ejection forces.
Adhesion of Tablets in a Rotary Tablet Press II. Effects of Blending Time, Running Time, and Lubricant Concentration
Drug Development and Industrial Pharmacy, 1982
ABSTRACT Abstract Of the three essential functions of tablet lubricants, only the true lubricant ... more ABSTRACT Abstract Of the three essential functions of tablet lubricants, only the true lubricant and glidant properties have been studied in detail by objective means. Only recently has instrumentation which permits the objective measurement of the antiadhesion activity in a rotary tablet press been developed. Using a rotary press instrumented to measure the adhesion of tablets to the lower punch face, this study focuses on the adhesion of tablets in two direct compression systems. At any given compression force, adhesion of microcrystalline cellulose tablets lubricated with magnesium stearate appeared to decrease with increases in blending time or intensity of blending. Over a three-hour running time, adhesion force was found to increase to peak values and then to decline with both microcrystalline cellulose and hydrous lactose lubricated with magnesium stearate. However, ejection forces decreased gradually to apparently limiting values in each case. The adhesion of tablets to the lower punch face appeared to be affected partly by the condition of the tablet - die wall interface. Studies comparing lubricated and unlubricated microcrystalline cellulose suggest two opposing effects on tablet adhesion: (1) enhancing adhesion due to an increased reaction at the lower punch resulting from reduced die wall friction; and, (2) reducing the adhesion of tablets via the “antiadherent” effect. At the lubricant levels studied, stearic acid generally appeared to be less efficient than magnesium stearate in reducing both the adhesion and ejection forces in microcrystalline cellulose blends. However, with hydrous lactose blends, the true lubricant and antiadherent activities of stearic acid appeared to be greater than those of magnesium stearate at the 1.00% level of addition.
Formulation of Specialty Tablets for Slow Oral Dissolution
Pharmaceutical Dosage Forms - Tablets
CRC Press eBooks, Jun 3, 2008
Formulation and Characterization of a Compacted Multiparticulate System for Modified Release of Water-Soluble Drugs – Part 1 Acetaminophen
Drug Development and Industrial Pharmacy, Mar 1, 2009
Variations in the friction coefficients of tablet lubricants and relationship to their physicochemical properties
Journal of Pharmacy and Pharmacology, Aug 1, 1988
A previously described modified annular shear cell (MASC) has been used to measure the friction c... more A previously described modified annular shear cell (MASC) has been used to measure the friction coefficients of some powdered tablet lubricants on a steel surface. Commonly used lubricants, as well as others belonging to the stearate group, differed in their friction coefficients at equivalent sample sizes and in the degree of their ability to reduce friction with increasing amounts when evaluated by the apparatus. In all comparisons, magnesium stearate had the lowest friction coefficient. Divalent salts of stearic acid appeared to be better than the other lubricants tested, and among themselves differed only in the extent of their ability to decrease friction. The lubricants also differed in their physical and chemical properties. On evaluation by stepwise regression analysis, such physical properties as projected surface area of lubricant particles, Martin’s diameter and bulk density accounted for most of the variation in friction coefficients of the lubricants rather than moisture content or melting point. It could therefore be suggested that particle size and/or surface area parameters be incorporated in product specifications to ensure reproducible functionality.
In silico formulation: application of artificial intelligence in support of hard gelatin capsule formulation of biopharmaceutics classification system class ii drugs
Guo et al have demonstrated that a prototype hybrid expert network (PEN) for capsule formulation ... more Guo et al have demonstrated that a prototype hybrid expert network (PEN) for capsule formulation is capable of yielding formulations that meet specific manufacturing and performance criteria for the model Biopharmaceutics Classification System (BCS) Class II drug piroxicam (Pharm Tech NA (26:9) 2002, p. 44). Purpose. The overall objective of this project is to assess the application of artificial intelligence in capsule formulation support of BCS Class If drugs. The phases of this project include: (1) Characterize model BCS Class II drugs based on physiochemical properties associated with solubility; (2) Evaluate the dissolution performance of the capsule formulations; (3) Generalize the PEN for formulation of model drugs; (4) Apply a Bayesian Network (BN) to formulation development of the model drugs. Methods. The model drugs used in this project were carbamazepine (CAR), chlorpropamide (CHL), diazepam (DIA), ibuprofen (IBU), ketoprofen (KET), naproxen (NAP) and piroxicam (PIR). The micromeritic properties, aqueous solubilities, contact angles, specific surface areas (SSA) and intrinsic dissolution rates (IDR) of these actives were characterized. Capsule formulations of each active were manufactured based on a Box-Behnken experimental design, varying the filler type/ratio and the amounts of lubricant, wetting agent and disintegrant. Dissolution performance of these capsules was characterized using USP standard dissolution media. This data was used to generalize the PEN and to develop a BN. Results. The model drugs were subdivided into weak acids and weak bases. A dataset containing SSA, contact angles, IDRs and percent drug dissolved at 10, 30 and 45 minutes for the model drugs was used as the basis for training the PEN. The system was successfully able to predict the dissolution performance of the model drugs. A BN was successfully developed to model the relationships between formulation variables and dissolution performance. Conclusions. Testing of the PEN indicates that the system can predict the dissolution performance of BCS Class II drugs and can be successfully generalized. The BN has proven to be a useful tool for formulation development. Within the scope of this research, this project proves that artificial intelligence can be successfully applied to pharmaceutical research and development.
Comparative evaluation of layering and film coating processes
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Papers by larry augsburger