X. Muylder

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The interpretation of the fetal heart rate during labour

Acta anaesthesiologica Belgica, 1981

Infarctus myocardique durant la grossesse: à propos d'un cas traité par angioplastie transluminale percutanée et implantation d'un stent coronarien

Gynécologie Obstétrique & Fertilité, 2007

Reçu le 26 septembre 2006 ; accepté le 18 décembre 2006 Disponible sur internet le 12 juin 2007 R... more Reçu le 26 septembre 2006 ; accepté le 18 décembre 2006 Disponible sur internet le 12 juin 2007 Résumé L'infarctus myocardique aigu survient rarement au cours de la grossesse et est associé à une augmentation nette de la mortalité maternelle et foetale. Nous rapportons le cas d'une patiente dont la grossesse a été compliquée par un infarctus myocardique aigu survenu à 17 semaines d'âge gestationnel. Après un essai de thrombolyse, la patiente a bénéficié d'un traitement par angioplastie et stenting coronarien. Nous discutons du diagnostic et de la prise en charge de l'infarctus myocardique durant la grossesse. © 2007 Elsevier Masson SAS. Tous droits réservés.

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Gynaecology. Hormonal interventions and cancer risk

Lancet

[Radioimmunoassay of HCG and HCG beta in blood during pregnancy and trophoblastomas]

Journal de gynécologie, obstétrique et biologie de la reproduction, 1977

This work was carried out on 151 estimations of the radioimmune levels of hCG-hCG beta in the fir... more This work was carried out on 151 estimations of the radioimmune levels of hCG-hCG beta in the first half of normal pregnancy and 390 levels estimated in 10 molar pregnancies, in 4 choriocarcinomata following moles and 1 primary choriocarcinoma of the ovary using homologous hCG beta. In normal pregnancy the level of hCG-hCG beta rises rapidly. The levels are highest between the 8th and 9th weeks of pregnancy, and then gradually decrease. In active molar pregnancies the levels of hCG-hCG beta in the plasma are significantly higher than those found in normal pregnancies of the same gestational age. When the outcome is going to be favourable the levels drop progressively. Complete absence in peripheral blood is usually found about 14 weeks after a mole has been expelled or evacuated. In choriocarcinomata, if the level of hCG-hCG beta rises it is a certain sign of reactivation of the tumour.

Hormone receptor status in primary postmeuopausal breast cancers. Is there an association with hormone replacement therapy?

Oral Contraceptives and Prolactinomas

Obstetrical & Gynecological Survey, 1983

ABSTRACT s: The amenorrhea-galactorrhea syndrome is one of the most frequent clinical entities ob... more ABSTRACT s: The amenorrhea-galactorrhea syndrome is one of the most frequent clinical entities observed in patients with secondary amenorrhea. It occurred in 25.7 per cent of 300 consecutive cases studied by the present authors. The availability of prolactin assays and sella turcica tomography could account for the relatively large number of newly diagnosed cases of this abnormality. Other factors, however, could be involved. Estrogens are clearly capable of stimulating prolactin secretion in humans, and the question has been raised as to whether (C) Williams &amp; Wilkins 1983. All Rights Reserved.

Tamoxifen-Induced Endometrial Polyp

New England Journal of Medicine, 1997

... The New England Journal of Medicine Dr. Kaplan replies: To the Editor: Dr. Caldwell is correc... more

Effects of tamoxifen on uterus

The Lancet, 1994

Effects of tamoxifen on uterus. By - SM Ismail, TH Bourne, WP Collins, S Campbell, TJ Powles, Pat... more

Longitudinal hysteroscopic follow-up during tamoxifen treatment

The Lancet, 1998

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Ureteric complications of radical hysterectomy: role of catheters

Journal of Obstetrics and Gynaecology, 1985

Endometrial lesions in patients undergoing tamoxifen therapy

International Journal of Gynecology & Obstetrics, 1991

Forty-six nonhysterectomized women treated with tamoxifen during 6-36 months as adjuvant therapy ... more Forty-six nonhysterectomized women treated with tamoxifen during 6-36 months as adjuvant therapy for breast cancer underwent a hysteroscopy to assess the endometrial effects of this drug. Whereas the endometrium was normal among 23 patients, 13 presented with endometrial polyps, 8 with hyperplasia and 2 with adenocarcinoma. The rate of endometrial lesions was directly related to the cumulative dose of tamoxifen but it was not statistically different among patients receiving progestational therapy compared to patients who did not receive this therapy.

Fetal Heart Rate in the Second Stage of Labour Method of Interpretation and Parameters of the New-Born

Gynecologic and Obstetric Investigation, 1979

The authors present a protocol for the interpretation of the fetal heart rate during the second s... more The authors present a protocol for the interpretation of the fetal heart rate during the second stage of labour (limited to the last 30 min before delivery). The FHR recordings were grouped according to five classes of increasing pathological significance. Good correlations were obtained between these classifications and the Apgar score as well as the umbilical artery pH.

Usefulness of urodynamic investigations in female incontinence

European Journal of Obstetrics & Gynecology and Reproductive Biology, 1992

Urinary incontinence in females has been evaluated in a prospective series of 408 patients by com... more Urinary incontinence in females has been evaluated in a prospective series of 408 patients by comparing the clinical diagnosis and the subsequent urodynamic findings. The presenting symptoms or combination of symptoms were shown to have only a limited diagnostic predictive value as measured by urodynamic diagnostic criteria. The symptom of stress incontinence was a sensitive detector of genuine stress incontinence (94% sensitivity) but was not very specific (65%). The symptoms of urgency and urge incontinence were found to have limited sensitivity (62%) and specificity (47%) in the detection of detrusor instability. Even patients with isolated complaints of stress incontinence have an incidence of detrusor instability of 52%, whereas 76% of those with a history of isolated urgency and urge incontinence had detrusor instability. An urodynamic evaluation should be performed on most female patients suffering from urinary incontinence and is essential for patients who are being considered for surgery of stress incontinence.

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Hormone receptor status in primary postmenopausal breast cancers. Is there an association with hormone replacement therapy?

European Journal of Cancer, 2002

Immunohistochemical investigation of ER and PR expression in primary breast cancer and their axillary lymph node metastases

European Journal of Cancer, 2002

III.1 Tamoxifen and the uterus—the hysteroscopic approach

European Journal of Cancer, 1998

All our hysteroscopic observations over the last 10 years strongly support that tamoxifen has an ... more All our hysteroscopic observations over the last 10 years strongly support that tamoxifen has an endometrial effect not seen with synthetic oestrogens. The development of small sized instruments, combined with an atraumatic insertion technique have made hysteroscopy a simple and safe procedure that can be performed on an outpatient base without any form of anaesthesia and with good patient compliance. In long-term tamoxifen users, hysteroscopy enables us to differentiate between atrophic endometria with glandulocystic changes in the underlying stroma and endometrial polyps mainly of the glandulocystic type. The diagnostic value of direct visualisation with the advantage of being able to guide endometrial biopsies is superior to any indirect technique like transvaginal ultrasonography (TVU). 0

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II.2 Tamoxifen and benign endometrial lesions

European Journal of Cancer, 1998

Early Breast Cancer Triallists' Collaborative Group E. Systemic treatment of early breast cancer ... more Early Breast Cancer Triallists' Collaborative Group E. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomized trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet 1992, 339, 1-15. Powles T, Hardy J, Ashley S, et al. A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer. BrJCuncer 1989, 60, 126-131. Jones A, Powles T, Treleaven J, er al. Haemostatic changes in 4.

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The immunocytochemical versus cytosol measurement of the oestrogen receptor in invasive breast cancer tissue

European Journal of Cancer, 2000

To compare two methods of measurement of oestrogen receptor (ER)-expression in invasive breast ca... more To compare two methods of measurement of oestrogen receptor (ER)-expression in invasive breast cancer tissue. Sections from 299 breast cancer cases were stained for the ER by immunocytochemical assay (ICA), using mouse monoclonal antibody (MAb) NCL-ER-6SF11, and by the dextran-coated charcoal assay (DCC). Concordant results were observed in 230 of the 299 cases (77%), 69 patients had discordant results (kappa=0.537). We found a moderate concordance between ICA and DCC for ER measurement in breast cancer tissue. If we change the golden standard from DCC to ICA, 23% of patients would receive a dierent therapeutic approach. #

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I.2 From the breast to the uterus. The past and the present

European Journal of Cancer, 1998

Since 1985 we have witnessed an overall reduction in breast cancer mortality in the U.K. which in... more Since 1985 we have witnessed an overall reduction in breast cancer mortality in the U.K. which in large part must be attributed to the widespread adoption of adjuvant tamoxifen, but it is essential not to be complacent and it is likely that we are close to recognising the limitations of this useful and relatively non-toxic agent [20,2 11. 1. Taivesimi IA. Buzdar AU. Decker DA. et al. Preview Article: use 1976, i, 885-887. Horwitz RI, Feinstein AR, Horwitz SM, Robboy SJ. Necropsy diagnosis of endometrial cancer and detection-bias in caseicontrol studies. Lancet 1981, ii, 66-68. GiufTiida D, Lupo L, La Porta GA et cd. Relation between steroid receptor status and body weight in breast cancer patients. Eur J Cancer 1992,28A, 112-l 15. Ferrazzi E, Cartei G, Mattarazz.0 R, Fiorentino M. Oestrogenlike effect of tamoxifen on vaginal epithelium. BY Med 3 1977, 1, 1351-1352. Ass&is VJ, Neven P, Jordan VC, Vergote I. A realistic clinical perspective of tamoxifen and endometrial carcinogenesis. Eur 3

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Effect of tamoxifen on bone

BMJ, 1993

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