Indian Journal of Medical and Paediatric Oncology, 2016
study of children with high-risk HL, the escalated BEACOPP (e-BEACOPP) produced a 5-year event-fr... more study of children with high-risk HL, the escalated BEACOPP (e-BEACOPP) produced a 5-year event-free survival (EFS) of 94% and an overall (OS) of 97%. In another study, the ABVE-PC regimen had an EFS of 84% in high-risk patients and 85% in intermediaterisk patients. Available studies from India indicate ABVD, COPP-ABVD, and COPP-ABV are the regimens commonly used in Indian children; but there is no data on the use of ABVE-PC or BEACOPP. Herein, we report our limited experience with these two regimens in Indian children with intermediate and high-risk HL respectively, and review the literature on the efficacy of these regimens in children.
Objective To define the efficacy and safety of low-dose rasburicase in children from south India ... more Objective To define the efficacy and safety of low-dose rasburicase in children from south India with hematologic malignancies. Methods This study is a retrospective analysis of data on 41 children with hematologic malignacies with laboratory evidence of tumor lysis syndrome (TLS) or clinical features indicating high risk for developing TLS. Patients were treated with rasburicase in doses of 0.1-0.15 mg/kg dose, repeated when necessary. Results Male : Female ratio was 32:9. Thirty-six children had laboratory evidence of TLS and 5 were at risk for TLS. Diagnoses were T-cell acute lymphoblastic leukemia (ALL), 19; Pre-B ALL, 17; B-non-Hodgkin lymphoma (NHL), 2; T-NHL, 2; and acute myeloid leukemia (AML), 1. Initial plasma uric acid (PUA): median, 8.5 mg/dl (range, 4.3 to 45.5). Six had creatinine levels of >2 mg/dl on admission; and 10 had peak PO 4 levels of >10 mg/dl. Dose of rasburicase used: median, 0.12 mg/kg (range, 0.08-0.24). Median reduction of PUA at 6 h: 80 % (range 40 to 98 %). Twenty-seven needed only one dose; 12 needed 2 or 3 doses; and two needed 5 doses each. One child required dialysis. None of the children developed anaphylaxis or hemolysis and there were no deaths from TLS. Conclusions Low-dose rasburicase (0.1-0.15 mg/kg) is safe and effective in reducing PUA in Indian children with lymphoid malignancies, and thus it may reduce the risk of renal failure from TLS.
A Concept Note to Prevent Construction Workers from Ergonomic Threats
Construction industry is the most hazardous industry compared to mining, manufacturing and agricu... more Construction industry is the most hazardous industry compared to mining, manufacturing and agriculture, etc. New hazards are arising daily in the form of chemical, physical, biological and ergonomics while performing different tasks. Hazards in construction industry affect the health and safety of workers and also the productivity of firms. Hazards associated with construction projects are worker tools, equipment’s, materials and workplace environment. Ergonomic hazard can be physical, physiological, environment factors within the workplace that can harm the musculoskeletal system of the workers. The outcome of the ergonomics factors is musculoskeletal disorder injuries which affects the muscles, tendons and vessels of the workers body. The factors which affect the musculoskeletal system include repetitive work, awkward positions, static posture, contact stress, vibration and sudden force, etc. This is because of poor design of tools, materials, equipment and workplace of the constr...
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Papers by Vignesh Kumar