Papers by Ummu Afeera Zainulabid
Malignant lung carcinoid tumour
PLOS ONE
SARS-CoV-2 has spread throughout the world since its discovery in China, and Malaysia is no excep... more SARS-CoV-2 has spread throughout the world since its discovery in China, and Malaysia is no exception. WGS has been a crucial approach in studying the evolution and genetic diversity of SARS-CoV-2 in the ongoing pandemic. Despite considerable number of SARS-CoV-2 genome sequences have been submitted to GISAID and NCBI databases, there is still scarcity of data from Malaysia. This study aims to report new Malaysian lineages of the virus, responsible for the sustained spikes in COVID-19 cases during the third wave of the pandemic. Patients with nasopharyngeal and/or oropharyngeal swabs confirmed COVID-19 positive by real-time RT-PCR with CT value < 25 were chosen for WGS. The selected SARS-CoV-2 isolates were then sequenced, characterized and analyzed along with 986 sequences of the dominant lineages of D614G variants currently circulating throughout Malaysia. The prevalence of clade GH and G formed strong ground for the presence of two Malaysian lineages of AU.2 and B.1.524 that h...
Bangladesh Journal of Medical Science
Background: Hepatitis C is one of the most common causes of liver disease worldwide. Health impac... more Background: Hepatitis C is one of the most common causes of liver disease worldwide. Health impacts of hepatitis C are not limited to physical morbidity but include psychosocial dimensions such as quality of life (QOL), depression, anxiety, and stigmatization. In Malaysia, modifiable factors that can improve QOL among hepatitis C patients have not been adequately studied. Resilience – defined as the capacity to endure hardships and rebound from life adversities – is associated with mental health and well-being. Our study aims to test the association between resilience and QOL among hepatitis C patients. Methods: Employing a cross-sectional design, 195 hepatitis C patients who attended Hospital Tengku Ampuan Afzan (HTAA) – the main public tertiary hospital in Pahang – were recruited through convenience sampling. Resilience was assessed using the Connor-Davidson resilience scale while Health-Related Quality of Life (HRQOL) was measured by 36-item short-form survey (SF-36v2). Multiple ...
The SARS-CoV-2 has spread throughout the world since its discovery in China, and Malaysia is no e... more The SARS-CoV-2 has spread throughout the world since its discovery in China, and Malaysia is no exception. WGS has been a crucial approach in studying the evolution and genetic diversity of SARS-CoV-2 in the ongoing pandemic, and while an exceptional number of SARS-CoV-2 complete genomes have since been submitted to GISAID and NCBI, there is a scarcity of data from Malaysia. This study aims to report new Malaysian lineages responsible for the sustained spikes in COVID-19 cases during the third wave of the pandemic. Patients whose nasopharyngeal and oropharyngeal swabs were confirmed positive by real-time RT-PCR with Ct-value < 25 were chosen for WGS. The 10 SARS-CoV-2 isolates obtained were then sequenced, characterized and analyzed, including 1356 sequences of the dominant lineages of D614G variant currently circulating throughout Malaysia. The prevalence of clade GH and G formed strong ground of the discovery of two Malaysian lineages that caused sustained spikes of cases local...
Bangladesh Journal of Medical Science, 2021
Background: Hepatitis C is one of the most common causes of liver disease worldwide. Health impac... more Background: Hepatitis C is one of the most common causes of liver disease worldwide. Health impacts of hepatitis C are not limited to physical morbidity but include psychosocial dimensions such as quality of life (QOL), depression, anxiety, and stigmatization. In Malaysia, modifiable factors that can improve QOL among hepatitis C patients have not been adequately studied. Resilience-defined as the capacity to endure hardships and rebound from life adversities-is associated with mental health and well-being. Our study aims to test the association between resilience and QOL among hepatitis C patients. Methods: Employing a cross-sectional design, 195 hepatitis C patients who attended Hospital Tengku Ampuan Afzan (HTAA)-the main public tertiary hospital in Pahang-were recruited through convenience sampling. Resilience was assessed using the Connor-Davidson resilience scale while Health-Related Quality of Life (HRQOL) was measured by 36-item short-form survey (SF-36v2). Multiple linear r...
Acute parkinsonism following streptococcal infection is rarely reported. To date, there is paucit... more Acute parkinsonism following streptococcal infection is rarely reported. To date, there is paucity of literature of post streptococcal immune mediated acute parkinsonism and dyskinesia among adult. We report a case of 18 years old woman, who presented with acute parkinsonism after streptococcal tonsillitis. The patient who was previously well presented with a two-month history of intermittent fever, associated with sore throat and sudden onset of behaviour changes. She has been found to be quieter and respond slowly to questions and commands in the preceding one week prior to admission. Features of secondary parkinsonism was noted during examination. Her blood counts, viral screenings and anti-NMDAR were unremarkable. Her lumbar puncture revealed an opening pressure of 10 cm CSF with normal constituents. The ASO titre was raised up to 400IU/ml. Electroencephalogram (EEG) shows mild encephalopathy changes and MRI brain shows normal finding. She was initially treated initially for men...
Background: There are several serological tests used in the diagnosis of melioidosis. However, th... more Background: There are several serological tests used in the diagnosis of melioidosis. However, the interpretation of the results can be problematic in endemic areas because there might be a high background positivity due to previous exposure. Objective: This study aimed to determine the usefulness of Indirect Immunofluorescent Antibody (IFA) IgM and IgG in the diagnosis of melioidosis and the time for seroconversion. Methodology: We prospectively studied the trend of IFA IgM and IgG in 40 patients with culture-confirmed melioidosis over three months at six different time points (days 1, 8, 15, 30, 60, and 90). Results: From the results, 37.5% and 32.5% of patients had IFA IgM and IgG of ≤ 1:20 respectively on day 1 when the blood culture was positive. The natural log (ln) of the titres was used for the analysis. Repeated measures ANOVA showed significant changes in both IgM (p= 0.001) and IgG (p= 0.045) respectively throughout six sampling time points. Both the means of ln IgM and l...
International Journal of Human and Health Sciences (IJHHS)
Pulmonary phaeohyphomycosis is a rare infection in the lung caused by black fungi containing a cy... more Pulmonary phaeohyphomycosis is a rare infection in the lung caused by black fungi containing a cytoplasmic melanin-like pigment. A 42-year-old man with underlying retroviral disease on HAART was investigated for having constitutional symptoms. Despite undetectable viral load and a high CD4 count, he was found to have unexplained significant loss of weight and appetite over a period of 6 months. Clinical examination revealed a cachexic man with multiple inguinal lymphadenopathies. Excisional biopsy of the inguinal lymph node revealed reactive follicular hyperplasia. CT Thorax, Abdomen and Pelvis was arranged to look for occult malignancy or infection and he was found to have multiple non-enhancing subcentimeter lung nodules mainly at the lateral segment of the right middle lobe of his lung. The largest nodule measured about 0.8 x 1.5 x 0.5 (AP x W x CC), with some nodules having an irregular margin with no extension into the adjacent bronchi. Bronchoscopy was done and demonstrated a ...
COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang
Materials Today: Proceedings
Microbiology Resource Announcements
Here, we report the nearly complete genome sequences of nine SARS-CoV-2 variants with the D614G m... more Here, we report the nearly complete genome sequences of nine SARS-CoV-2 variants with the D614G mutation. These viruses were detected from various infected individuals with different levels of severity from Pahang, Malaysia. In addition, this study described the presence of lineage B.1.351 as a type of variant of concern (VOC), lineage B.1.466.2, and lineage B.1.524 as a local variant.
International Journal of Human and Health Sciences (IJHHS)
Acute pancreatitis related to mumps infection is rarely reported. In this case report, we highlig... more Acute pancreatitis related to mumps infection is rarely reported. In this case report, we highlight a case of acute pancreatitis caused by mumps infection in adulthood. A 25-year old woman treated for mumps developed sudden onset of vomiting and epigastric pain. She had an elevation of serum amylase and was treated for acute pancreatitis. She showed remarkable improvement of clinical symptoms with supportive treatment and after her bilateral parotid swelling receded.International Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 261-263
International Journal of Human and Health Sciences (IJHHS)
The pleuropulmonary solitary fibrous tumour (SFT) is a rare type of tumour. This paper outlined a... more The pleuropulmonary solitary fibrous tumour (SFT) is a rare type of tumour. This paper outlined a 63-year-old female who came to the hospital with two weeks history of chronic cough, shortness of breath, and hypoglycemia. Contrast-Enhanced CT Thorax showed a huge heterogeneously-enhancing mass occupying the right hemithorax. US-guided biopsy followed by histological examination showed the features of an SFT. In view of the association between pleuropulmonary SFT and hypoglycaemia, the patient was highly likely to be suffering from a paraneoplastic syndrome known as Doege-Potter Syndrome.International Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 251-253
International Journal of Human and Health Sciences (IJHHS)
Atypical lung carcinoid tumour, which is highly malignant has not been described widely in the li... more Atypical lung carcinoid tumour, which is highly malignant has not been described widely in the literature. We report a middle-age woman who initially referred for possible lung malignancy. She presented with chronic diarrhoea to surgical team initially, who incidentally found to have a minimally enhancing irregular hypodense lesion at medial segment right lower lobe based on CT thorax finding. This patient later was diagnosed to have malignant lung carcinoid tumour based on histopathological examination with liver and bone metastasis. This case highlights the rare presentation of carcinoid tumour. A thorough history, supplemented by imaging and bronchoscopic examinations may lead to the diagnosis.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 108-111
International Journal of Human and Health Sciences (IJHHS)
Pulmonary herpes simplex infection is rarely reported. To date, there is a paucity of literature ... more Pulmonary herpes simplex infection is rarely reported. To date, there is a paucity of literature on this infection. This case study describes a 64-year-old male with a background history of diabetes mellitus and hypertension who was intubated for acute respiratory failure. The managing team had difficulty to wean his oxygenation thus decided for bronchoscopy examination which showed suspicious growth at middle lobe of the right lung. Repeated bronchoscopy by pulmonologist revealed a nodular ‘warty’ appearance lesion at right bronchus intermedius. His biopsy revealed histopathological changes consistent with herpes simplex infection.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 112-114
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Papers by Ummu Afeera Zainulabid