Papers by Simão Lottenberg
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2017
This study evaluated the relationship between the zinc-related nutritional status and glycemic an... more This study evaluated the relationship between the zinc-related nutritional status and glycemic and insulinemic markers in individuals with type 2 diabetes mellitus (T2DM). A total of 82 individuals with T2DM aged between 29 and 59 years were evaluated. The concentration of zinc in the plasma, erythrocytes, and urine was determined by the flame atomic absorption spectrometry method. Dietary intake was assessed using a 3-day 24-h recall. In addition, concentrations of serum glucose, glycated hemoglobin percentage, total cholesterol and fractions, triglycerides, and serum insulin were determined. The insulin resistance index (HOMA-IR) and β-cell function (HOMA- β) were calculated. The markers of zinc status (plasma: 83.3±11.9μg/dL, erythrocytes: 30.1±4.6μg/g Hb, urine: 899.1±622.4μg Zn/24h, and dietary: 9.9±0.8mg/day) were classified in tertiles and compared to insulinemic and glycemic markers. The results showed that lower zinc concentrations in plasma and erythrocytes, as well as its...
Einstein, 2006
As sociedades modernas, especialmente aquelas que se encontram em transição para um estilo de vid... more As sociedades modernas, especialmente aquelas que se encontram em transição para um estilo de vida ocidental, vem apresentando um aumento significativo da prevalência da obesidade, que em muitos locais apresentam características epidêmicas. Apesar de ser amplamente reconhecido o papel de fatores genéticos, a explosão da obesidade observada nos últimos cem anos não pode ser explicada por alterações gênicas que tenham ocorrido neste curto espaço de tempo, mas sim, pelas mudanças ocorridas no meio ambiente conseqüentes ao intenso processo de industrialização e aos avanços tecnológicos que ocorreram no mundo contemporâneo. As determinantes que levaram ao aumento ponderal corporal se relacionam basicamente às mudanças ambientais a que indivíduos geneticamente suscetíveis ao ganho de peso se expuseram, aumentando a ingestão calórica e de gorduras, reduzindo a atividade física frente ao estilo de vida característico da vida moderna. Baseado na maior disponibilidade e menor custo dos alimentos, na excessiva mecanização e automatização que tornam o indivíduo mais sedentário e na maior pressão psicológica de natureza profissional e social, o homem moderno vem sofrendo uma significativa alteração de seu comportamento de natureza obesogênica, que será discutido no presente trabalho. Considerando que a obesidade é universalmente reconhecida como um importante fator de risco para as doenças cardiovasculares e o diabetes, é necessária maior atenção do ponto de vista de saúde publica em não somente tratar, mas principalmente prevenir a obesidade modificando o ambiente "tóxico" com base em estratégias que promovam mudanças comportamentais ou que obtenham novas tecnologias alimentares.
Objective: To study diabetic and non diabetic patients in UTI, regardingthe prevalence of broad s... more Objective: To study diabetic and non diabetic patients in UTI, regardingthe prevalence of broad spectrum beta-lactamase producing pathogensand quinolone resistance. Methods: Inclusion criteria for this studywas the presence of positive urine culture and fasting glucose equal toor above 126 mg/dl and below 100 mg/dl. We managed to include 494patients, 210 diabetics and 284 non-diabetics. Results: Escherichiacoli was the most frequently found pathogen in both diabetic andnon-diabetic groups, and significantly more frequent in non diabeticpatients (p = 0.0001) – 60% to 31% when compared to their diabeticcounterparts. Candida albicans infecting the urinary tract was foundin 30% of diabetics and in 16% of non-diabetics (p = 0.003). Broadspectrum beta-lactamase production was more frequently present inKlebsiella pneumoniae, however without significant difference betweenthe groups. Broad spectrum beta-lactamase production was morefrequent in diabetic patients (12%) than in non-diabetics (4...
Arquivos Brasileiros de Cardiologia, 2014
Os anúncios veiculados nesta edição são de exclusiva responsabilidade dos anunciantes, assim co... more Os anúncios veiculados nesta edição são de exclusiva responsabilidade dos anunciantes, assim como os conceitos emitidos em artigos assinados são de exclusiva responsabilidade de seus autores, não refletindo necessariamente a opinião da SBC. Material de distribuição exclusiva à classe médica. Os Arquivos Brasileiros de Cardiologia não se responsabilizam pelo acesso indevido a seu conteúdo e que contrarie a determinação em atendimento à Resolução da Diretoria Colegiada (RDC) nº 96/08 da Agência Nacional de Vigilância Sanitária (Anvisa), que atualiza o regulamento técnico sobre Propaganda, Publicidade, Promoção e informação de Medicamentos. Segundo o artigo 27 da insígnia, "a propaganda ou publicidade de medicamentos de venda sob prescrição deve ser restrita, única e exclusivamente, aos profissionais de saúde habilitados a prescrever ou dispensar tais produtos (...)". Garantindo o acesso universal, o conteúdo científico do periódico continua disponível para acesso gratuito e integral a todos os interessados no endereço: www.arquivosonline.com.br.
Biotin interference in immunoassays mimicking subclinical Graves’ disease and hyperestrogenism: a case series
Clinical Chemistry and Laboratory Medicine (CCLM), 2017
*Corresponding author: Marcelo C. Batista, MD, Clinical Laboratory, Hospital Israelita Albert Ein... more *Corresponding author: Marcelo C. Batista, MD, Clinical Laboratory, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, Bloco E – 2° andar – Laboratório Clínico, São Paulo – SP CEP 05652-900, Brazil, Phone: +55 11 2151-5555, Fax: +55 11 2151-0408, Cell phone: 55 11 99140-0282, E-mail: marcelo.batista@einstein.br Carlos E.S. Ferreira: Clinical Laboratory, Hospital Israelita Albert Einstein, São Paulo, Brazil; and Department of Laboratory Medicine, Universidade Federal de São Paulo – UNIFESP, São Paulo, Brazil Adriana C.L. Faulhaber, Simão A. Lottenberg and Cristóvão L.P. Mangueira: Clinical Laboratory, Hospital Israelita Albert Einstein, São Paulo, Brazil Jairo T. Hidal: Department of Endocrinology, Hospital Israelita Albert Einstein, São Paulo, Brazil Letter to the Editor
Einstein (São Paulo), 2011
Objective: To evaluate the impact of screening hyper and hypoglycemia measured by capillary glyce... more Objective: To evaluate the impact of screening hyper and hypoglycemia measured by capillary glycemia and standard monitorization of hyperglycemic patients hospitalized in regular care units of Hospital Israelita Albert Einstein. Methods: The capillary glycemia was measured by the Precision PCx (Abbott) glucosimeter, using the PrecisionWeb (Abbott) software. The detection of hyper and hypoglycemia during the months of May/June were compared to those of March/April in 2009 and to the frequency of the diagnosis of diabetes in 2007. Results: There was an increase in the glycemia screening from 27.7 to 77.5% of hospitalized patients (p…
Disturbances of lipid metabolism in hypothyroidism studied by artificial chylomicrons
Anais, 1990
Simultaneous measurements of chylomicron lipolysis and remnant removal using a doubly labeled artificial lipid emulsion: studies in normolipidemic and hyperlipidemic subjects
Journal of Lipid Research, 1994
An artificial chylomicron-like lipid emulsion doubly labeled with tri[(N)3H]oleoylglycerol ([3H]T... more An artificial chylomicron-like lipid emulsion doubly labeled with tri[(N)3H]oleoylglycerol ([3H]TO) and cholesteryl [1-14C]oleate ([14C]CO) was infused intravenously into human subjects with the purpose of simultaneously measuring the plasma disappearance rates (residence time, RT) of [14C]CO, which represents solely the splanchnic organ uptake of the remnant chylomicron core, and of [3H]TO, which combines the remnant disappearance with the shedding off of chylomicron triglycerides by the action of lipoprotein lipase. Thus, the fraction of the particle triglyceride content that is removed before the remnant is taken up is expressed as a delipidation index (DI = 1 - RT of [3H]TO/RT of [14C]CO. The present procedure has an advantage over the use of chylomicrons labeled with retinyl ester or radioactive triglycerides alone that represent, respectively, the chylomicron remnant or the whole particle metabolism only. When normal subjects as well as primary hyperlipidemic subjects were studied, the plasma triglyceride concentration was directly related to [14C]CO RT and [3H]TO RT, but inversely related to the delipidation index. There may be different patterns of relations between these parameters of chylomicron metabolism in primary and in secondary hyperlipidemias, as well as under the action of drugs that influence the metabolism of lipoproteins.
Apolipoprotein and genotyping frequences in hypercholesterolemic and diabetic individuals
Abstracts, 1996
Artificial chylomicrons metabolism as a probe for the plasma lipid lowering drug action mechanism
Anais, 1990
Artificial doubly labeled chylomicron-like emulsions simultaneously measure the particle lipolysis and remnant removal rates: studies in normolipidemic and hyperlipidemic subjects
AbstractObjectives: To discuss the metabolic syndrome and identify itsrisk factors, including in ... more AbstractObjectives: To discuss the metabolic syndrome and identify itsrisk factors, including in the pediatric age group. Sources: Indexed review articles. Summary of the findings: The metabolic syndrome ischaracterized by insulin resistance and the presence of risk factorsforcardiovasculardiseasesanddiabetesmellitustype2.Consensushas not yet been reached on its diagnostic criteria. This reviewpresents diagnostic criteria defined by the American HeartAssociation (US National Cholesterol Education Program), theAmerican Association of Clinical Endocrinologists, the World HealthOrganization and the International Diabetes Federation anddiscusses the possibilities of applying them to children.Pathophysiologic features of the syndrome are also covered,principally those related to the perinatal period and childhood. Conclusions: The metabolic syndrome is being diagnosed withever greater frequency, principally during adolescence. Lifestylechanges,suchastodietandlevelofphysicalactivityarefun...
Simultaneous measurements of chylomicron lipolysis and remnant removal using a doubly labeled artificial lipid emulsion: studies in normolipidemic and hyperlipidemic subjects
Journal of Lipid Research, 1994
An artificial chylomicron-like lipid emulsion doubly labeled with tri[(N)3H]oleoylglycerol ([3H]T... more An artificial chylomicron-like lipid emulsion doubly labeled with tri[(N)3H]oleoylglycerol ([3H]TO) and cholesteryl [1-14C]oleate ([14C]CO) was infused intravenously into human subjects with the purpose of simultaneously measuring the plasma disappearance rates (residence time, RT) of [14C]CO, which represents solely the splanchnic organ uptake of the remnant chylomicron core, and of [3H]TO, which combines the remnant disappearance with the shedding off of chylomicron triglycerides by the action of lipoprotein lipase. Thus, the fraction of the particle triglyceride content that is removed before the remnant is taken up is expressed as a delipidation index (DI = 1 - RT of [3H]TO/RT of [14C]CO. The present procedure has an advantage over the use of chylomicrons labeled with retinyl ester or radioactive triglycerides alone that represent, respectively, the chylomicron remnant or the whole particle metabolism only. When normal subjects as well as primary hyperlipidemic subjects were studied, the plasma triglyceride concentration was directly related to [14C]CO RT and [3H]TO RT, but inversely related to the delipidation index. There may be different patterns of relations between these parameters of chylomicron metabolism in primary and in secondary hyperlipidemias, as well as under the action of drugs that influence the metabolism of lipoproteins.
Physiological Reports, 2021
This is an open access article under the terms of the Creative Commons Attribution License, which... more This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Th-P15:154 Aerobic exercise training reduces the pre-beta 1 HDL generation and enhances the HDL3 antioxidant role in type 2 diabetes mellitus subjects
Atherosclerosis Supplements, 2006
s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... more s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 001 AEROBIC EXERCISE TRAINING REDUCES PRE-BETA1 HDL GENERATION AND ENHANCES THE HDL3 ANTIOXIDANT ROLE IN TYPE 2 DIABETES MELLITUS
Revista da Associação Médica Brasileira, 2010
Os objetivos deste estudo foram: caracterizar a polifarmácia entre portadores de Diabetes Mellitu... more Os objetivos deste estudo foram: caracterizar a polifarmácia entre portadores de Diabetes Mellitus tipo2(DM2); e correlacionar polifarmácia e número de complicações do DM2 com indicadores de depressão (Inventário de Depressão de Beck[IDB] e cortisol urinário[CORT]). A amostra foi composta por 40 pacientes da Liga de Diabetes do HCFM-USP, avaliados quanto aos indicadores de depressão (CORT e IDB) e quanto à prática de polifarmácia e número de complicações do DM2. Os resultados mostraram que os medicamentos utilizados foram: antidiabéticos orais, insulinas, anti-hipertensivos, diuréticos, anti-lipêmicos e trombolíticos. No grupo estudado, 75% fizeram uso diário de 5 a 8 medicamentos, e 12,5% de 8 medicamentos/dia ou mais; todos fizeram no mínimo 3 tomadas diárias, 60% tinham entre 1 e 3 complicações do DM2, e 22,5% tinham 3 ou mais. A correlação entre os indicadores de depressão(IDB e CORT), o número de medicamentos e o número de complicações do DM2 não foi estatisticamente significante. No entanto, houve correlação positiva entre CORT e número de tomadas diárias de medicamentos (Spearman,r=0.319, p=0.019).
Jornal de Pediatria, 2007
Objectives: To discuss the metabolic syndrome and identify its risk factors, including in the ped... more Objectives: To discuss the metabolic syndrome and identify its risk factors, including in the pediatric age group. Sources: Indexed review articles. The metabolic syndrome is characterized by insulin resistance and the presence of risk factors for cardiovascular diseases and diabetes mellitus type 2. Consensus has not yet been reached on its diagnostic criteria. This review presents diagnostic criteria defined by the American Heart Association (US National Cholesterol Education Program), the American Association of Clinical Endocrinologists, the World Health Organization and the International Diabetes Federation and discusses the possibilities of applying them to children. Pathophysiologic features of the syndrome are also covered, principally those related to the perinatal period and childhood. The metabolic syndrome is being diagnosed with ever greater frequency, principally during adolescence. Lifestyle changes, such as to diet and level of physical activity are fundamental to prevention. Treatment with medication and, in extreme cases, with surgery should also be considered, depending on severity and age.
Revista Latino-Americana de Enfermagem, 2009
OBJECTIVE: To determine which of two simplified blood glucose monitoring schemes promotes better ... more OBJECTIVE: To determine which of two simplified blood glucose monitoring schemes promotes better metabolic control in type1 diabetic patients during 12 months of participation in educational groups. METHODS: A crossover clinical trial involving 21 patients divided into two groups was conducted. They were submitted to a two monitoring schemes:2 alternate daily preprandial measurements and 2 alternate daily pre-and postprandial measurements. The effectiveness of the schemes was evaluated based on HbA1c. Variations in mean HbA1c were analyzed by Friedman test. RESULTS: The groups were homogenous in terms of sociodemographic and clinical variables…
HDL Atheroprotection by Aerobic Exercise Training in Type 2 Diabetes Mellitus
Medicine & Science in Sports & Exercise, 2008
In this study we analyzed the role played by aerobic exercise training in the plasma lipoprotein ... more In this study we analyzed the role played by aerobic exercise training in the plasma lipoprotein profile, prebeta 1-HDL concentration, and in the in vitro HDL3 ability to remove cholesterol from macrophages and inhibit LDL oxidation in type 2 diabetes mellitus (DM) patients and control subjects, in the fasting and postprandial states. Healthy controls (HTC, N = 11; 1 M/10 F) and subjects with type 2 diabetes mellitus (DMT, N = 11; 3M/8F) were engaged in a 4-month aerobic training program, and compared with a group of sedentary subjects with type 2 diabetes mellitus (DMS, N = 10; 4 M/6 F). All groups were submitted to an oral fat load test to analyze all parameters, both at the beginning of the investigation protocol (basal) and at the end of the study period (final). Exercising did not modify body weight, BMI, plasma concentrations of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides (TG), glucose, insulin, or HOMA-IR, but it reduced the waist circumference. The HDL3 composition did not change, and its ability to remove cell cholesterol was unaltered by aerobic training. In DMT but not in HTC, aerobic training improved 15% the HDL3 protective effect against LDL maximal oxidation rate in the fasting state, and reduced 24% the plasma prebeta 1-HDL concentration in the postprandial state, suggesting an enhanced prebeta 1-HDL conversion into larger, more mature HDL particles. In this regard, regular aerobic exercise enriched HDL2 with TG in the fasting and postprandial states in HTC and in the fasting phase in DMT. Our results show that aerobic exercise training in diabetes mellitus improves the HDL efficiency against LDL oxidation and favors HDL maturation. These findings were independent of changes in insulin resistance and of the rise of plasma HDL cholesterol concentration.
The impact of dietary fatty acids on macrophage cholesterol homeostasis
The Journal of Nutritional Biochemistry, 2014
The impact of dietary fatty acids in atherosclerosis development may be partially attributed to t... more The impact of dietary fatty acids in atherosclerosis development may be partially attributed to their effect on macrophage cholesterol homeostasis. This process is the result of interplay between cholesterol uptake and efflux, which are permeated by inflammation and oxidative stress. Although saturated fatty acids (SAFAs) do not influence cholesterol efflux, they trigger endoplasmic reticulum stress, which culminates in increased lectin-like oxidized LDL (oxLDL) receptor (LOX1) expression and, consequently, oxLDL uptake, leading to apoptosis. Unsaturated fatty acids prevent most SAFAs-mediated deleterious effects and are generally associated with reduced cholesterol efflux, although α-linolenic acid increases cholesterol export. Trans fatty acids increase macrophage cholesterol content by reducing ABCA-1 expression, leading to strong atherosclerotic plaque formation. As isomers of conjugated linoleic acid (CLAs) are strong PPAR gamma ligands, they induce cluster of differentiation (CD36) expression, increasing intracellular cholesterol content. Considering the multiple effects of fatty acids on intracellular signaling pathways, the purpose of this review is to address the role of dietary fat in several mechanisms that control macrophage lipid content, which can determine the fate of atherosclerotic lesions.
Uploads
Papers by Simão Lottenberg