Papers by Santosh Waghmare
Zenodo (CERN European Organization for Nuclear Research), Jun 15, 2022
Melasma is a common acquired disorder of hyperpigmentation that commonly affects those with skin ... more Melasma is a common acquired disorder of hyperpigmentation that commonly affects those with skin of color. Tranexamic acid (TXA) is a novel treatment for melasma that has a multimodal mechanism of action. To provide a comprehensive review of the literature regarding the evidence on the mode of action, safety profile, and efficacy of TXA in the treatment of melasma. The literature was searched for publications on TXA in the treatment of melasma using MEDLINE, Scopus, and Google Scholar. The abstracts of the articles were screened and reviewed for relevance. The selected articles were read in detail for inclusion and also the relevant references were traced. This review is an attempt to evaluate the role of TA by various routes in melasma and offer suggestions for future directions of research. The abstracts of the articles were screened and reviewed for relevance. The selected articles were read in detail for inclusion and also the relevant references were traced. This review is an attempt to evaluate the role of TA by various routes in melasma and offer suggestions for future directions of research..
Analytical Chemistry Letters, May 4, 2021
International Journal of Research Publication and Reviews
The global pandemic of SARS- CoV- 2, the causative viral pathogen of COVID- 19, has driven the bi... more The global pandemic of SARS- CoV- 2, the causative viral pathogen of COVID- 19, has driven the biomedical community to action to uncover and develop antiviral interventions. One implicit remedial approach presently being estimated in multitudinous clinical trials is the agent remdesivir, which has endured a long and winding experimental path. Remdesivir as a medicine attracted a veritably serious consideration of whole Globe in treatment of the epidemic complaint COVID19. More lately published in- vitro inhibition exertion and in- vivo case studies were showing promising clinical results and outgrowth of effective inhibition of SARS- CoV- 2 contagion by the use of remdesivir. Still at the same time, use of the remdesivir showed substantial mischievous adverse events in cases which needs a special attention during treatment course of COVID- 19. Therefore, the use of remdesivir in treatment of COVID- 19 is having current transnational interest although some further clinical attestatio...
Parkinson’s disease (PD) is a common neurodegenerative disease typified by a movement disorder co... more Parkinson’s disease (PD) is a common neurodegenerative disease typified by a movement disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment options for PD are limited, with most of the current approaches based on restoration of dopaminergic tone in the striatum. However, these do not alter disease course and do not treat the non-dopamine-dependent features of PD such as freezing of gait, cognitive impairment, and other non-motor features of the disorder, which often have the greatest impact on quality of life. As understanding of PD pathogenesis grows, novel therapeutic avenues are emerging. These include treatments that aim to control the symptoms of PD without the problematic side effects seen with currently available treatments and those that are aimed towards slowing pathology, reducing neuronal loss, and attenuating disease course. In this latter regard, there has been much interest in drug repurposing (the use of established drugs for ...
Zenodo (CERN European Organization for Nuclear Research), Feb 1, 2022
A novel Quality by Design methodology was used to develop and validate a rapid, accurate, precise... more A novel Quality by Design methodology was used to develop and validate a rapid, accurate, precise, simple, efficient and reproducible isocratic Reversed Phase-High Performance Liquid Chromatographic (RP-HPLC) method for the estimation of Luliconazole in bulk and pharmaceutical dosage form. Luliconazole was separated using Kromasil C18 column (250mm×4.6 mm, 5µm particle size), Shimadzu LC2030 HPLC system having UV detector and the mobile phase contained a mixture of 0.01M Ammonium acetate buffer and Acetonitrile (35:65). The flow rate was set to 1.2 ml/min with the responses measured at 294nm. The retention time of Luliconazole was found to be 3.092 min. Central composite design employed for design of experiment and optimization. Desirability value was found to be 0.723 and overall model was found to significant. Linearity was established for Luliconazole in the range of 20-120 µg/ml with correlation coefficient (r2=0.9995). Limit of detection (LOD) and limit of quantitation (LOQ) were evaluated and found to be 1.1700 and 3.5455 respectively. The accuracy values were found to be in the range of 98 -102% and every parameter found with in limit. Validation parameters were evaluated for the method according to the International Conference on Harmonization (ICH) Q2 R1 guidelines. This method can be used for the estimation and analysis of Luliconazole drug in active pharmaceutical ingredients and pharmaceuticals.
International Journal of Engineering Applied Sciences and Technology
Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance o... more Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when bacteria change in response to the use of these medicines.Bacteria, not humans or animals, become antibiotic-resistant. These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria.Antibiotic resistance leads to higher medical costs, prolonged hospital stays, and increased mortality.The world urgently needs to change the way it prescribes and uses antibiotics. Even if new medicines are developed, without behaviour change, antibiotic resistance will remain a major threat. Behaviour changes must also include actions to reduce the spread of infections through vaccination, hand washing, practising safer sex, and good food hygiene.
International Journal for Research in Applied Science and Engineering Technology
Accuracy, precision, specificity, linearity, range, the limit of detection, the limit of quantifi... more Accuracy, precision, specificity, linearity, range, the limit of detection, the limit of quantification, robustness, and system suitability testing.
Oral administration of medicine in one of the preferred route and extensively used expression for... more Oral administration of medicine in one of the preferred route and extensively used expression for new living and new medicines. The new generation of oral medicine delivery system technologies brings precious benefits to cases. Oral route is the most accessible and generally route of medicine delivery. It might be due to its ease of administration and utmost impotently patient compliance. Oral controlled release phrasings are designed to deliver a medicine at a pre determined rate by achieving a constant medicine position for a specified period of time with lower side goods. Controlled release medicine delivery have come a significant precedence worldwide, it may be possible to achieve rapid-fire immersion of medicine and increased memoir vacuity, reduced toxin and bettered patient compliance. The oral route is by far the most common route of medicine administration in the gastrointestinal tract and can be used for both systemic medicine delivery and for treating original gastrointestinal conditions. It's the most favored route by cases, due to its advantages, similar as ease of use,noninvasiveness, and convenience for toneadministration. Phrasings can also be designed to enhance medicine delivery to specific regions in the upper or lower gastrointestinal tract. Despite the clear advantages offered by the oral route, medicine delivery can be grueling as the mortal gastrointestinal tract is complex and displays a number of physiological walls that affect medicine delivery. A recent report by new England health care institute stated that the cost of non-compliance alone in us was around$ 290 billion, 13 of total periodic health care expenditure. Further over oral specifics bettered patient compliance and results in affective treatment which redounded in invention in oral medicine delivery system.
Journal of Drug Delivery and Therapeutics, May 15, 2019
Human Immunodeficiency Virus (HIV) is an enveloped virus, belonging to the viral family Retroviri... more Human Immunodeficiency Virus (HIV) is an enveloped virus, belonging to the viral family Retroviridae. It is a highly evolved virus which has grasped the attention of all researchers with its special features like morphology, genetics and also by its emerging nature 3 . The special feature of all retro viruses is the presence of an enzyme called Reverse transcriptase which plays major role in reverse transcription process 4 . HIV enters the host body, damages immune system and will cause life-threatening opportunistic infections finally leads to AIDS (Acquired Immunodeficiency Syndrome).Many advances have been made in the prevention of HIV transmission and management of HIV/AIDS since the virus was discovered in the early 1980s 7 . One of the most important discoveries has been antiretroviral treatment, which can halt the replication of HIV and ease symptoms, turning AIDS into a chronic condition instead of a rapidly terminal illness. Despite advances, HIV remains a major public health challenge. This article reviews the genus, life cycle, and transmission of HIV, as well as workplace issues surrounding the virus and the challenges of developing an HIV vaccine 12 .
Journal of emerging technologies and innovative research, Sep 1, 2021
In vitro fertilization (IVF) is a complex step of procedures used to help with fertility. During ... more In vitro fertilization (IVF) is a complex step of procedures used to help with fertility. During IVF, mature eggs are collected (retrieved) from ovaries and fertilized by sperm in a lab. Then the fertilized egg (embryo) or eggs (embryos) are transferred to a uterus. One full cycle of IVF takes about three weeks. Sometimes these steps are divided into different parts and the process can take longer. IVF is the most effective form of assisted reproductive technology. The procedure can be done using your own eggs and your partner's sperm. Your chances of getting healthy baby using IVF depend on many factors, such as your age and the cause of infertility. In other hand, IVF can be time-consuming, expensive and invasive.
Journal of emerging technologies and innovative research, Sep 1, 2021
Pharmacovigilance defined as "the science and activities relating to the detection, assessment, u... more Pharmacovigilance defined as "the science and activities relating to the detection, assessment, understanding, monitoring and prevention of adverse effects related to drugs. Pharmacovigilance play important role in public health by monitoring and interaction of drug and there impact on human being. Aim of Pharmacovigilance is patient safety. This review article contain guidelines such as Good Clinical Practice (GCP) and International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH).India becomes third largest country in world for pharmaceuticals production. In India these days Pharmacovigilance bring to public attention importance about reporting of adverse drug reaction. This review article brief about activities related to the pharmacovigilance.
In today's pharmaceutical industry, optimization has arisen as a technique for finding the be... more In today's pharmaceutical industry, optimization has arisen as a technique for finding the best compromise response to a specific problem. The term optimization refers to the process of improving something or making it work better. Finding a perfect, effective, or functional solution is what optimization is all about. The goal of this review article is to identify the many strategies that can be used to improve the quality, safety, and efficacy of pharmaceutical formulations by looking at the most appropriate and practicable experimental designs and optimization techniques, by investigating the most appropriate and practical experimental designs and optimization approaches for pharmaceutical formulations.
A simple, specific, accurate, and precise r everse p hase High Performance Liquid Chromatographic... more A simple, specific, accurate, and precise r everse p hase High Performance Liquid Chromatographic (RP-HPLC) method was developed and validated for the estimation of Dapoxetine H C l in bulk and pharmaceutical dosage forms. A Symmetry C18, 3.5 µ m column having 250 mm x 4.6 mm in isocratic mode, with mobile phase containing HPLC grade Acetonitrile, Ammonium format (60 : 40 v/v, pH 3.5) was used. The flow rate was 1 ml/min and effluent was monitored at 292 nm. Chromatogram showed a main peak of Dapoxetine H C l at retention time of 5.020 ± 0.0078 min. The Correlation coefficient was 0.999. The method was validated for linearity, sensitivity, precision, accuracy, robustness. The limit of detection and limit of quantitation for estimation of Dapoxetine H C l was found to be 0. 1 4 2 and 0.471, respectively. Recovery of Dapoxetine was found to be in the range of 98.93-99.91 %. Proposed method was successfully applied for the quantitative determination of Dapoxetine H C l in bulk and phar...
Distilled water
A simple, precise and accurate UV spectrophotometric method has been developed and validated for ... more A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The spectra of Telmisartan in 0.1 N NaOH and distilled water (20:80) shows λmax at 234 nm and estimation was carried out by A (1 % 1cm) and by comparison with standard. Calibration graph was found to be linear (r 2 = 0.999) over the concentration range of 2-10 μg/mL. The proposed method was validated for its accuracy, precision, specificity, ruggedness and robustness. The method can be adopted in its routine analysis.
Development and validation of first order and second order derivative UV spectrophotometric method for determination of sitagliptin phosphate and simvastatin in bulk and in formulation
International Journal of Advanced Scientific Research, 2017
Biomarkers are very important and can provide crucial information on the rapid events and molecul... more Biomarkers are very important and can provide crucial information on the rapid events and molecular mechanisms in pathophysiology. Obtaining a profile of distinct classes of biomarkers reflecting core pathologic mechanisms could enable us to identify and characterize the initial injury and the secondary pathologic cascades. Accordingly, great effort has been put into the identification of novel biomarkers in the past 25 years. However, the role of various organs injury markers in clinical practice has been long debated, due to inconsistent regulatory standards and lack of reliable evidence of analytical validity and clinical utility. We present a comprehensive overview of the markers currently available while characterizing their potential role and applications in diagnosis, monitoring, drug discovery, and clinical trials.
Analytical Chemistry Letters, 2021
Journal of Drug Delivery and Therapeutics, 2019
Tablets or capsules taken orally remain one of the most effective means of treatment available. T... more Tablets or capsules taken orally remain one of the most effective means of treatment available. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The present study reveals the evaluation of four marketed sample of Telmisartan tablets. The main aim of the study is to conduct dissolution test on the tablets to determine the compliance with a given official monograph. Four different marketed samples of Telmisartan were purchased from local market. The Telmisartan tablets were evaluated for the various in-vitro tablet properties such as thickness, hardness, friability, weight variation, drug content, disintegration time and dissolution rate. In-vitro dissolution test is conducted on four different brands of telmisartan tablets to assess their equivalency. All the four marketed samples of Telmisartan have shown good tablet properties and comply with the pharmacopoeial specifi...
Journal of Drug Delivery and Therapeutics, 2018
Cancer" is the term we give to a large group of diseases that vary in type and location but have ... more Cancer" is the term we give to a large group of diseases that vary in type and location but have one thing in common: abnormal cells growing out of control. It continues multiplying uncontrollably and the result of this accumulation of abnormal cells is a mass of cells called a "cancer" 1, 2 . The Plant Kingdom produces naturally occurring secondary metabolites which are being investigated for their anticancer activities leading to the development of new clinical drugs. Vinca Alkaloids, Texans, podo phyllotoxin, Camptothecins have been clinically used as Plant derived anticancer agents 20. With the success of these compounds that have been developed into staple drugs for cancer treatment new technologies are emerging to develop the area further. New technologies include nanoparticles for Nano-medicines which aim to enhance anticancer activities of plant-derived drugs by controlling the release of the compound and investigating new methods for administration 1 . The purpose of this brief review is to assemble current literature on some herbal drugs and to focus on their beneficial roles and drug targets in cancer therapy and chemoprevention. The present review summarizes the literature published so far regarding herbal medicine used as anti-cancer herbal drugs 20 . This review discusses the demand for naturally-derived compounds from medicinal plants and their properties which make them targets for potential anticancer treatments.
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Papers by Santosh Waghmare