Ran Mu

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Application of Soil Moisture Data Assimilation in Flood Forecasting of Xun River in Hanjiang River Basin

Water

Accurate projection of floods is of great significance to safeguard economic and social developme... more Accurate projection of floods is of great significance to safeguard economic and social development as well as people’s life and property. The development of hydrological models can improve the level of flood projection, however, the numerous uncertainties in the models limit the projection accuracy. By adding observations to correct the operation of prediction models, the accuracy can be improved to some extent. In this paper, taking the Xun River, of the Hanjiang River Basin in China, as the research object, combined with the soil moisture satellite data obtained by the soil moisture active and passive satellite (SMAP), the ensemble Kalman filter (EnKF) algorithm was used to assimilate the upper soil water content (WU) of the Xinanjiang model. In addition, based on the simultaneous assimilation of state variables and parameters, two improved assimilation schemes were proposed here, namely, the augmented ensemble Kalman filter (AEnKF) scheme and the dual ensemble Kalman filter (DEn...

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An integrated model for optimal water resources allocation under “3 Redlines” water policy of the upper Hanjiang river basin

Journal of Hydrology: Regional Studies

Flood risk analysis of reservoirs based on full-series ARIMA model under climate change

Journal of Hydrology

Addressing Spatial Heterogeneity in the Discrete Generalized Nash Model for Flood Routing

Water, 2021

River flood routing is one of the key components of hydrologic modeling and the topographic heter... more River flood routing is one of the key components of hydrologic modeling and the topographic heterogeneity of rivers has great effects on it. It is beneficial to take into consideration such spatial heterogeneity, especially for hydrologic routing models. The discrete generalized Nash model (DGNM) based on the Nash cascade model has the potential to address spatial heterogeneity by replacing the equal linear reservoirs into unequal ones. However, it seems impossible to obtain the solution of this complex high order differential equation directly. Alternatively, the strict mathematical derivation is combined with the deeper conceptual interpretation of the DGNM to obtain the heterogeneous DGNM (HDGNM). In this work, the HDGNM is explicitly expressed as a linear combination of the inflows and outflows, whose weight coefficients are calculated by the heterogeneous S curve. Parameters in HDGNM can be obtained in two different ways: optimization by intelligent algorithm or estimation base...

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Scalable total synthesis of a mycobactin T analogue utilizing a novel synthetic and protection strategy

Organic Chemistry Frontiers, 2019

Mycobactin T analogue 1 (MbT-1) is a mycobacterial-specific siderophore analogue, which is usuall... more

Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

ACS Infectious Diseases, 2019

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Nitrooxidoreductase Rv2466c-Dependent Fluorescent Probe for Mycobacterium tuberculosis Diagnosis and Drug Susceptibility Testing

ACS Infectious Diseases, 2019

This study firstly demonstrated that natural product-inspired coumarin-based nitrofuranylcalanoli... more This study firstly demonstrated that natural product-inspired coumarin-based nitrofuranylcalanolides (NFCs) can form Rv2466c-mycothiol (MSH)-NFC (RvMN) ternary complex via NFC binding to W21, N51 and Y61 of Rv2466c and be specifically reduced by Rv2466c, which is accompanied with the generation of high level of fluorescence. Additionally, the results unveiled that the acetylated cysteine-glucosamine motif (AcCys-GlcN) of MSH is sufficient to interact with Rv2466c and adopt the active conformation that is essential for fully reducing NFCs. Further clinical translational investigation in this article indicated that the novel fluorescent NFC probe can serve as a much needed high-throughput and low-cost detection method for rapid detection of living Mtb and precise determination of MIC values of a full range of available drugs. This method can greatly facilitate the development of phenotypic drug-susceptibility testing (pDST) that will allow the point-of-care of treatment of TB within a week after diagnosis.

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Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis

ACS infectious diseases, Jan 21, 2018

The success of Mycobacterium tuberculosis (Mtb) as a pathogen depends on the redundant and comple... more The success of Mycobacterium tuberculosis (Mtb) as a pathogen depends on the redundant and complex mechanisms it has evolved for resisting nitrosative and oxidative stresses inflicted by host immunity. Improving our understanding of these defense pathways can reveal vulnerable points in Mtb pathogenesis. In this study, we combined genetic, structural, computational, biochemical, and biophysical approaches to identify a novel enzyme class represented by Rv2466c. We show that Rv2466c is a mycothiol-dependent nitroreductase of Mtb and can reduce the nitro group of a novel mycobactericidal compound using mycothiol as a cofactor. In addition to its function as a nitroreductase, Rv2466c confers partial protection to menadione stress.

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