new complex copper compounds with ligands (histidine and argenine) with the composition [CuCl2L (... more new complex copper compounds with ligands (histidine and argenine) with the composition [CuCl2L (H2O)] H2O, [CuCl2L2] , [CuCl2L (H2O)] 3H2O were synthesized. It is shown that the composition of the complexes obtained depends on the ratio of the initial components. The composition and structure of the complexes were studied by chemical analysis, IR spectroscopy, and thermogravimetry. The method of IR and UV spectroscopy showed that the ligands in the composition of the honey (II) complexes enter into the neutral form and are coordinated with the complexing agent through the nitrogen atom. The results of thermogravimetric studies have shown that the final product of the thermal decomposition of all compounds is copper oxide, respectively.
Background There is evidence that one of the key type 2 diabetes (T2D) loci identified by GWAS ex... more Background There is evidence that one of the key type 2 diabetes (T2D) loci identified by GWAS exerts its influence early on in life through its impact on pediatric BMI. This locus on 10q23 harbors three genes, encoding hematopoietically expressed homeobox (HHEX), insulin-degrading enzyme (IDE) and kinesin family member 11 (KIF11), respectively. Methods We analyzed the impact of adipogeneis on the mRNA and protein expression levels of these genes in the human adipocyte Simpson-Golabi-Behmel syndrome (SGBS) cell line in order to investigate which could be the culprit gene(s) in this region of linkage disequilibrium. Results Following activation of differentiation with a PPARγ ligand, we observed ~20% decrease in IDE, ~40% decrease in HHEX and in excess of 80% decrease in KIF11 mRNA levels when comparing the adipocyte and pre-adipocyte states. We also observed decreases in KIF11 and IDE protein levels, but conversely we observed a dramatic increase in HHEX protein levels. Subsequent t...
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Papers by Rahim Aziz