Increased iron levels have been demonstrated in the basal ganglia of manifest Huntington's diseas... more Increased iron levels have been demonstrated in the basal ganglia of manifest Huntington's disease (HD). An excess in iron accumulation correlates with MRI T2-weighted hypointensity. Determination of the amount of hypointensities in the basal ganglia in the premanifest phase of HD may give more insight in the role of iron in the pathogenesis of HD. Therefore, the present study assessed whether the degree of hypointensities on T2-w MRI in the basal ganglia of premanifest gene carriers differs from non-carriers. Seventeen HD gene carriers without clinical motor signs and 15 non-carriers underwent clinical evaluation and MRI scanning. The amount of T2-w hypointensities was determined using a computer-assisted quantitative method that classified each pixel in the basal ganglia as hypointense or not, resulting in a total of hypointense pixels for each individual. Carriers showed an increased amount of hypointensities in the basal ganglia compared to non-carriers. More hypointensities were furthermore associated with a higher UHDRS total motor score, a longer CAG repeat length and a greater probability of developing symptoms within 5 years. We concluded that the increased amount of hypointensities in the basal ganglia of premanifest carriers of the HD gene may reflect excessive iron deposition and a role for iron in the neuropathology of HD. Furthermore, this phenomenon is associated with clinical and biological disease characteristics. An increased amount of hypointensities on T2-w MRI in the basal ganglia may be considered a biomarker for HD.
Proceedings of The 2012 Asia Pacific Signal and Information Processing Association Annual Summit and Conference, 2012
People affected by the loss of short term memory and cognitive impairment have serious difficulti... more People affected by the loss of short term memory and cognitive impairment have serious difficulties in communication. This may lead to social isolation and lack of community access, a fundamental key barrier to independence for people suffering from Alzheimer's Disease, the most common form of memory and cognitive impairment. We propose Automated Memory Support for Social Interaction (AMSSI), a system that helps memory impaired people with their social interaction. The system provides active support that may help reducing stress level of patients. AMSSI recognizes visitors, determines the purpose of the visit, monitors the dialogue, determines whether the patient needs support, and provides feedback. AMSSI is tailored to patient needs, it has fast computation, full automation, and can be handled by the patient without supervision. The proposed assistive system can be beneficial for improving the quality of life of patients with mild to moderate cognitive impairments. This paper ...
In this paper we describe integrated multimedia processing forVideo Scout, a system that segments... more In this paper we describe integrated multimedia processing forVideo Scout, a system that segments and indexes TV programsaccording to their audio, visual, and transcript information. VideoScout represents a future direction for personal video recorders. In addition to using electronic program guide metadata and a userprofile, Scout allows the users to request specific topics within aprogram. For example, users can request the video clip of the Presidentspeaking from a half-hour news program.
Current personal Video recorders make it very easy for consumers to record whole TV programs. Our... more Current personal Video recorders make it very easy for consumers to record whole TV programs. Our research however, focuses on personalizing TV at a sub-program level. We use a traditional Content-Baaed Information Retrieval system architecture consisting of archiving and retrieval modules. The archiving module employs a three-layered, multimodal integration framework to segment, analyze, characterize, and classify segments. The retrieval module relies on users' personal preferences to deliver both full programs and video segments of interest. We tested retrieval concepts with real users and discovered that they see more value in segmenting non-narrative programs (e.g. news) than narrative programs (e.g. movies). We benchmarked individual algorithms and segment classification for celebrity and financial segments as instances of narrative content. For celebrity segments we obtained a total precision of 94.1% and recall of and for financial segments a total precision of 8 1.1% an...
We analyse the structure of filters which are space-time oriented. Basically, this paper consists... more We analyse the structure of filters which are space-time oriented. Basically, this paper consists of two parts. In the first one, we present the cascade of space-time DOG as an energy filter, discuss its general properties and show how to compute its energy. In the second part, we discuss the consequences of applying the sampling theorem to uniformly translating patterns in the presence of motion uncertainty. It is shown that, for a given motion uncertainty, there exists a bound on the maximum sampling interval, such that for larger values aliasing will occur.
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Papers by Radu Jasinschi