Serum Matrix METALLOPROTEINASE-7 as a Diagnostic and Prognostic Biomarker for Extrahepatic Biliary Atresia
INDIAN JOURNAL OF APPLIED RESEARCH
Aim: Serum Matrix metalloproteinase-7 as a diagnostic and prognostic biomarker for extrahepatic b... more Aim: Serum Matrix metalloproteinase-7 as a diagnostic and prognostic biomarker for extrahepatic biliary atresia Methods: This was a prospective, single center, case control study where consecutive infants less than 6 months of age with obstructive jaundice (n=20) at MAMC from April 2021 to March 2023 were enrolled. Age and sex-matched controls (n=20) were also taken. Serum MMP-7 were tested in all 40 infants. In Case group, additional tests performed were, CBC, LFT to derive APRI and FIB-4 scores, Ultrasound Abdomen, Hepatobiliary scintigraphy, Per-operative cholangiogram, Pre and/or intraoperative liver biopsy. The Results: participants were substratied into EHBA (n = 11) and NH (n = 9) based on post priming hepatobiliary scintigraphy and Per-operative cholangiogram. Median serum MMP-7 level in EHBA was 23 ng/ml that was found to be 6 times higher than Neonatal hepatitis and 13 times higher than in normal infants. Median serum MMP-7 levels in NH group and normal infants were 4ng/m...
Neonatal Gastric Perforation: Review of 5 Years' Experience in a Tertiary Care Centre
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
Background: Gastric perforation among neonates is a rare but frequently fatal condition of uncert... more Background: Gastric perforation among neonates is a rare but frequently fatal condition of uncertain etiology. Although historically gastric perforation has often been described as “spontaneous'', some cases are non-spontaneous. The aim of this study was to review the clinical course of neonatal gastric perforation in a tertiary care center over the last ve years. Aim: Neonatal Gastric Perforation: Review of 5 Years' Experience in a tertiary care center. Material And Methods: It is a retrospective study where we obtained 5 years (2016-2021) data of neonates who were diagnosed with gastric perforation. Data of total 13 neonates were reviewed and tabulated. Factors were noted including age, sex, term or preterm (Gestational age), birth weight, mode of delivery, sign & symptoms, associated anomalies, respiratory distress at birth, mechanical ventilation before the development of signs & symptoms, site of perforation, Total leukocyte count and clinical outcome in terms of s...
Objective: To test the hypotheses that (1) there is no significant difference between the effects... more Objective: To test the hypotheses that (1) there is no significant difference between the effects of two burs on the surface roughness of enamel after orthodontic debonding, and (2) there is no difference between resin removal times of the two burs. Materials and Methods: The crowns of 20 premolars were embedded in acrylic blocks, and the buccal surfaces were subjected to atomic force microscopy (AFM), with measurement of initial roughness values. The brackets were bonded with a light-cured adhesive and were debonded with a debonding plier. In half of samples, adhesive remnants were removed with a tungsten carbide bur, whereas a fiber-reinforced composite bur was used in the other half. The second AFM measurements were made after resin removal. Duration of removal procedures was also recorded. Results of roughness and duration measurements were analyzed with the use of repeated measurements analysis of variance and independent t-tests, respectively. Results: The two resin removal instruments had significantly different effects on enamel roughness; higher average roughness (Sa) (P , .001), root mean square roughness (Sq) (P 5 .046), and maximum roughness depth (Smax) (P , .001) values were obtained with use of the tungsten carbide bur. Time required for resin removal with the composite bur was significantly greater than time required with the carbide bur (P , .001). The hypothesis is rejected. The composite bur used for resin removal creates smoother surfaces after orthodontic bonding; however, the process takes longer than it does when the tungsten carbide bur is used. (
Assessment of "Safe Zone" of Interradicular Spaces for Miniscrew Implant Placement: A Systematic Literature Review
The use of miniscrew implants as an orthodontic anchorage device has become an accepted method fo... more The use of miniscrew implants as an orthodontic anchorage device has become an accepted method for providing absolute anchorage. The purpose of this systematic review was to summarize the safe zones in the interradicular spaces for miniscrew implants placement. The PubMed electronic database was searched for original articles to the end of November 2015. The selection criteria were human anatomical studies, written in English, about the safe zones in the interradicular spaces for miniscrew implant placement. The final selection was completed after the authors read the complete articles. Most of these studies measured the availability of interradicular space in patients without malocclusion, i.e. no severe crowding, no spacing, no missing teeth except the third molars, and no periodontal disease, by using CT images. In these studies, types of occlusion or dento-skeletal patterns of the samples were not specified. In the maxilla and mandible, all interradicular sites had adequate spac...
Lasers have revolutionised the dentistry as with introduction of laser in the field of dentistry ... more Lasers have revolutionised the dentistry as with introduction of laser in the field of dentistry for last several years, it has emerged and witnessed several wonderful experiences by clinicians and the patients. They allow the dentist to reach sites where the conventional mechanical instrumentation fails. Since its first experiment for dental application in the 1960s, the use of laser has increased rapidly in the last decades. Because of their many advantages different types of lasers are available for clinical and specific use. They are activated at different power setting modes, and pulse for soft and hard tissues. This review discusses recent advancements in lasers and the applications in periodontics.
International Journal of Clinical Pediatric Dentistry, 2019
The pharyngeal airway, tongue, and hyoid bone are correlated. The hyoid bone is connected to the ... more The pharyngeal airway, tongue, and hyoid bone are correlated. The hyoid bone is connected to the pharynx, mandible, and cranium through muscles and ligaments and its position with respect to them determines the tongue posture and function. It also plays an important role in maintaining the airway and upright natural head position. Different skeletal patterns have different morphologies and shapes of the mandible, which might be affected by the position of the hyoid bone and the pharyngeal airway depth. This cephalometric study was conducted to relate the pharyngeal airway depth and the hyoid bone position of different skeletal patterns in sagittal dimension, and it determines and compares the linear parameters of the pharyngeal airway depth in Class I, II, and III malocclusion groups and anteroposterior, vertical, and angular positions of the hyoid bone positions in Class I, II, and III malocclusion groups. Materials and methods: Lateral cephalometric radiographs selected for study were divided into three groups of 30 samples each based on ANB angle and β angle into skeletal Class I, Class II, and Class III, respectively. Five linear measurements for the pharyngeal airway depth, four linear measurements for anteroposterior position, two linear measurements for vertical position, and one angular measurement for angular hyoid bone position were made. Results: The pharyngeal airway depth was found to show no statistically significant difference between Class I and Class III malocclusions. The pharyngeal airway depth in Class II malocclusion was found to be statistically smaller at D1 as compared to that in Class I and Class III malocclusions, whereas it remained the same at the rest of the locations measured, i.e., D2, D3, D4, and D5. The Class III malocclusion group showed a significant statistical difference in the anteroposterior hyoid bone position at all levels (i.e., H1, H2, H3, and H4) as compared to the Class II malocclusion group, whereas it showed a statistically significant difference as compared to the Class I malocclusion group at H1 and H3. The angular inclination of the hyoid bone in the Class II malocclusion group showed a statistically significant difference with the Class I and Class III malocclusion group but the Class III malocclusion group showed no significant difference statistically when compared to the Class I malocclusion group. The pharyngeal airway depth in the Class II malocclusion group was also found to be narrower at the superiormost level measured at the posterior nasal spine from the posterior pharyngeal wall. The hyoid bone position was variable in angular and anteroposterior dimensions among different malocclusion groups.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Oral lichen planus (OLP) is a common chronic mucocutaneous disease mostly seen in middle aged and... more Oral lichen planus (OLP) is a common chronic mucocutaneous disease mostly seen in middle aged and elderly females. Oral lichen planus can occur in different oral sites such as gingiva, labial, buccal mucosa and on the tongue. And can have an indirect effect on initiating periodontitis. The purpose of the study was to evaluate the periodontal status of OLP patients and compare it with that of healthy controls. The presence of erosive lesions among gingival tissues makes oral hygiene procedures difficult to perform for obvious reasons. Plaque control and rigorous oral hygiene are primary requisites for the treatment of any oro-mucosal disease. Thirty patients with the erosive and reticular form of OLP as a study group and 30 healthy subjects as a control group were selected. The periodontal status of all subjects including gingival index (GI), Russell's periodontal index (PI) and bleeding on probing (BOP) were evaluated in both groups. Finally, the data was analyzed by a paired t-...
Over the years, it has been known that 34% phosphoric acid is the benchmark in etchants with the ... more Over the years, it has been known that 34% phosphoric acid is the benchmark in etchants with the best shear bond strength shown with composites in primary teeth. However, with latest technological advancements and innovations, in order to reduce the number of steps and less damage to the tooth structure, non-rinse conditioner (NRC) & Single-Etch and various other etchants have been tried and tested. These etchants have been found to have shear bond strength comparable to phosphoric acid. In this study, indigenously prepared 24% ethylenediaminetetraacetic acid (EDTA) has been compared with established etchants, as to prove if their shear bond strength was closely related. As it is a well-known fact that EDTA could be less damaging to the enamel during etching and hence can be an alternative for etching of primary teeth. For the study 60 caries-free primary molars were used, they were sectioned in the middle, after making area for bonding; the marked area was then etched using differe...
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