Papers by Nikhilesh Singh
A questionnaire based study on student preparedness to web 2.0 at I MBBS entry level
Journal of Contemporary Medical Education, 2015
Objective: Various studies have reported the effectiveness of online teaching vis a vis tradition... more Objective: Various studies have reported the effectiveness of online teaching vis a vis traditional methods. But hardly have they reported whether the subjects involved in their studies have adequate access and working knowledge of computer/internet and they do not provide the exact framework to assess the preparedness of the students. Before moving on to adopting new teaching tool, it is necessary to determine whether the students are aptly prepared to accept and utilize the tool. Methodology: This project was designed to assess the preparedness of students for Web 2.0 teaching at I year MBBS entry level in a medical college using a questionnaire of 14 items to be responded on a Likert format. The data was analyzed for individual item responses and factor loadings. Results: Two predominant constructs came out as determinant of preparedness of students. In our results, students were in favour of implementation of web 2.0 teaching but most were inadequately prepared for the same. Conclusions: In previous studies, there have been conflicting results regarding the superiority of internet based teaching over traditional methods. Studies reporting the effectiveness of web 2.0 tools should also report on student preparedness for determining the actual effectiveness of the tool.
Advances in physiology education, 2018
To introduce active learning session for a large group of 250 students, we combined the strengths... more To introduce active learning session for a large group of 250 students, we combined the strengths of problem-based learning and team-based learning to promote a structured active learning strategy with less faculty involvement. For the implementation of this strategy, a case on anemia was selected based on the module already covered in classes. Structured exercises were preplanned on six different concepts that a student should possess for solving the problem. The large group of 250 students was divided into groups of 41 or 42 each. The groups were facilitated by one faculty member for one structured exercise. At the station, the group of 41 or 42 was further broken down into 6 smaller groups comprising 7 students each. After completion of the exercise, students cycled to the next exercise station facilitated by another faculty member. The case was solved in a plenary session. The effectiveness of the method was assessed by comparing the academic performance of the group with other ...
Oral Vehicle Compositions
Arabian Journal of Geosciences
Morphometric analysis has evolved as an important tool for basin management and to study the proc... more Morphometric analysis has evolved as an important tool for basin management and to study the process performing in the basin. The trio of remote sensing, GIS, and morphometric analysis gives the best possible results in investigating, supervising, and understanding the basin. The present study comprises a detailed study of morphometric parameters in a badland affected subwatershed of the Mandakini River. The sub-watershed is located in the northern foot slope of Vindhyan mountain range. The area consists of many structural and denudational hills, pediment, and pediplain complexes. Geologically soft sedimentary rocks are in the majority in this terrain and the area comprises a diverse range of gullies, in terms of shape and size. The intensity of the study is both macro and micro watershed level (up to the third and fourth sub-watershed level). The analysis is mostly based on derived parameters such as bifurcation ratio (Rb), drainage density (Dt), stream frequency (Fs), drainage texture (Dt), length of overland flow (Lg), and constant of channel maintenance (C), shape parameters such as circularity Ratio (Rc), elongation ratio (Re), form factor (Rf), and in relief parameter ruggedness number (Rn) and dissection index (Di). The analysis shows that low infiltration rate, i.e., a higher value of infiltration number (70.0), triggers high runoff and hence increases drainage density (4.5), drainage frequency (15.16), and drainage texture (25.23) and ultimately from an erosional setup in the sub-watershed and it is gradually deforming the land into a rugged terrain.
Mo1333 PHASE 1 RESULTS OF ORP-101, A NOVEL PARTIAL µ AGONIST, FULL κ ANTAGONIST WITHOUT OPIOID-LIKE ADVERSE EFFECTS, WHICH IS BEING DEVELOPED TO TREAT IBS-D
Gastroenterology
Usefulness of Multiple Choice Question-Based Online Formative Assessments for Determination of Item Statistics
Journal of Research in Medical Education & Ethics
A Novel Partial µ Agonist κ Antagonist for the Treatment of IBS-D without the Risk of Pancreatitis/Sphincter of Oddi Spasm
Gastroenterology
Method of treatment of obsessive compulsive disorder with ondansetron
Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form
Pharmacokinetics of the enantiomers of tiaprofenic acid in humans
Journal of Pharmaceutical Sciences, May 1, 1986
A gas chromatographic method was utilized to study stereoselective pharmacokinetics of the nonste... more A gas chromatographic method was utilized to study stereoselective pharmacokinetics of the nonsteroidal anti-inflammatory drug, tiaprofenic acid (5-benzoyl-alpha-methyl-2-thiopheneacetic acid), in four arthritic patients receiving 200 mg/8 h of the racemic drug. Synovial concentrations of the enantiomers were also measured following administration of single 200-mg doses of the drug to six other patients. In the analytical procedure, racemic tiaprofenic acid was coupled to (S)-(+)-amphetamine and the corresponding diastereoisomeric amide derivatives were resolved. Analysis of serial blood and urine samples at steady state, and single synovial samples, revealed that tiaprofenic acid enantiomers had superimposable plasma concentration-time and urinary excretion-time profiles and equivalent synovial concentrations. These results indicate that, unlike most 2-arylpropionic acid anti-inflammatory drugs, tiaprofenic acid enantiomers do not have different disposition kinetics, and the metabolic chiral inversion of one to the other does not occur or is so slow that the drug is eliminated before significant inversion takes place.
Solid compositions for treating middle-of-the-night insomnia
Oral vehicle compositions
Stabilized Zolpidem Pharmaceutical Compositions
Compositions for treating insomnia
Compositions and Methods for Treating Sleep Disorders
Cns Drugs, Dec 1, 2009
Background: Serotonin and dopamine neuronal systems have been implicated in the modulation of obs... more Background: Serotonin and dopamine neuronal systems have been implicated in the modulation of obsessive-compulsive disorder (OCD) symptoms. About 40% of OCD patients do not respond to first-line selective serotonin reuptake inhibitor (SSRI) treatment; among those, dopamine blocker augmentation has been reported to improve the rate of response by an additional one-third. Given that serotonin 5-HT3 receptors are indirect inhibitors of corticomesolimbic dopamine release, augmentation with the 5-HT3 receptor antagonist ondansetron in combination with SSRIs and antipsychotics has potential efficacy in treatment-resistant OCD patients. Objective: To assess the efficacy and tolerability of ondansetron in combination with SSRIs and antipsychotics in patients with treatment-resistant OCD. Method: In total, 14 patients with a DSM-IV diagnosis of OCD, who were treatment resistant and receiving stable treatment with SSRIs and antipsychotic augmentation, entered a 12-week, single-blind trial of ondansetron. The drug was initiated at a dosage of 0.25 mg twice daily for 6 weeks and was then titrated to 0.5 mg twice daily for 6 weeks. Results: Of the 14 patients, nine (64.3%) experienced a treatment response (>25% reduction in the Yale-Brown Obsessive Compulsive Scale [YBOCS] score and a Clinical Global Impressions-Improvement [CGI-I] score of 1 or 2) at 12 weeks. The average reduction in YBOCS-rated symptoms for the whole group was 23.2%. None of the treated patients experienced symptom exacerbation or significant adverse effects. Conclusion: These results suggest that low-dose ondansetron may have promise as an augmentation strategy for some patients with OCD resistant to SSRIs and antipsychotic augmentation, but further controlled trials are required. Trial registration number (ClinicalTrials.gov): NCT00796497 .
Compositions and Methods for Treating Middle-Of-The Night Insomnia
Hypnotic compositions and methods of use thereof
Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
Methods and Compositions for Delivering 5-HT3 Antagonists Across the Oral Mucosa
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Papers by Nikhilesh Singh