Jurnal Penelitian Kesehatan Suara Forikes/Jurnal penelitian kesehatan Suara Forikes, Mar 23, 2024
Events related to drug reactions are very difficult to recognize, because they often look like ot... more Events related to drug reactions are very difficult to recognize, because they often look like other diseases and many symptoms of drug reactions appear, especially for short drug exposures. Acute Kidney Injury is a condition that affects the structure and function of the kidneys, which is characterized by a sudden decrease in kidney function which causes necrosis of the tubules. The aim of this study was to analyze the prevalence of Drug-Induced Acute Kidney Injury and determine the main risk factors as well as drug data that can influence the increase in serum creatinine levels during treatment. This study implemented a cross-sectional design. The sampling location was the Medical Records section of Gatot Soebroto Army Hospital, with a sample size of 56 patients identified using the Kidney Disease Improving Global Outcomes (KDIGO) criteria and using trigger tools. Data were analyzed using the Chi-square test. The results of the analysis showed that the prevalence of Drug-Induced Acute Kidney Injury in the RSPAD Gatot Soebroto inpatient room was 8.975%-18.527%. Factors that influence the occurrence of Drug-Induced Acute Kidney Injury in the inpatient room were comorbidities (
The high demand for telepharmacy services led to the urge for proper training and education to en... more The high demand for telepharmacy services led to the urge for proper training and education to enhance their quality. This review aimed to assess the implementation and outcomes of telepharmacy training and education programs. This scoping review was conducted on ScienceDirect, Sage Journal, SpringerLink, and Google Scholar databases using the keywords "training" OR "education" AND "telepharmacy," "training" OR "education" AND "digital competency" AND "pharmacy." Only English-written articles published between 2000-2023, original research and brief report were included in this review. Eight of 171 articles met the criteria and the study's objectives. Those studies discussed telepharmacy learning program for pharmacy students in the USA (5 articles), UAE (2 articles), and Malaysia (1 article). The learning methods included didactic learning, case-based study, simulation/ roleplay, and clerkship employing technological tools. Rubrics, quizzes, questionnaires, and objective structured clinical examination (OSCE) were used as assessment methods. All studies reported improved students' knowledge, perceptions, and telepharmacy competencies. In conclusion, the telepharmacy learning programmes have effectively upgraded students' knowledge and skills by various methods at every level. However, there remains a considerable need for evidence on suitable training for pharmacists to improve their telepharmacy competencies and service quality.
Background Public health centres (PHCs) as primary healthcare in Indonesia were pivotal in handli... more Background Public health centres (PHCs) as primary healthcare in Indonesia were pivotal in handling COVID-19 detection, management, and reporting. Limited studies show various findings on COVID-19 management and its impact on further health risks, particularly in vulnerable populations like children under five years. Methods This cross-sectional study assessed secondary data from tracing reports, patient medical records, and integrated management childhood illness reports. Samples were collected using stratified random sampling based on three age groups (< 1 year, 1-3 years, 3-5 years) and the period of COVID-19 infection (2020, 2021, 2022) from ten district PHCs in East Jakarta. The collected data was analysed for descriptive, bivariate, and multivariate statistical analysis using IBM SPSS 26th version. Results 677 patients were included in this study, with the majority from 2021 (44.2%) with age 28 [0-60] months and male patients (52.6%). Only 4.14% of them have available recor...
Objective Genetic polymorphisms in ACE and ACE2 genes are involved in the RAS regulation of blood... more Objective Genetic polymorphisms in ACE and ACE2 genes are involved in the RAS regulation of blood pressure and their activity may confer susceptibility to hypertension. In addition, they may play a role in SARS-CoV-2 pathogenesis and the severity of COVID-19. This study aims to determine the effect of genetic variations in the ACE (rs4331) and ACE2 (rs2074192) genes with hypertension comorbidity on the severity of COVID-19 in the Indonesian population. Result 186 patients were enrolled and assigned into the COVID-19 group (n = 95) and non-COVID-19 group (n = 91) in this cross-sectional study. GG genotype frequency was dominant in ACE gene, but there were no significant differences between the groups (p = 0.163). The two groups had a significant difference (p = 0.000) for the CC genotype frequency (0,37 vs. 0.01) in the ACE2 gene. The proportion of women with COVID-19 is higher (51%), but men with hypertension had more severe symptoms (44%). Men with hypertension comorbidity, GG (ACE...
As an anticytokine therapy, tocilizumab has been recommended for the management therapy in patien... more As an anticytokine therapy, tocilizumab has been recommended for the management therapy in patients with severe and serious COVID-19 cases. The association between the severity of COVID-19 and blood groups has been the subject of prior research. Therefore, it is important to analyze the relationship between blood types and the effectiveness of tocilizumab (TCZ) therapy in COVID-19 patients. This research involved 68 patients diagnosed with severe and critical COVID-19 receiving Tocilizumab (TCZ) therapy at Universitas Indonesia Hospital. Blood type O was associated with a significantly improvement in CRP levels (P=0.014) and has better favorable outcomes compared to other blood type in terms of WHO Clinical
Medication adherence is important in controlling blood sugar levels (HbA1c) in patients with Diab... more Medication adherence is important in controlling blood sugar levels (HbA1c) in patients with Diabetes Mellitus (DM). Studies on the relationship between medication adherence and blood sugar control on the quality of life (QoL) in Type 2 DM patients are limited in Indonesia. This study aims to assess the relation between medication adherence with blood sugar control and the quality of life of Type 2 DM patients. This study used a cross-sectional design conducted at Universitas Indonesia Hospital. Medication Adherence Questionnaires and EuroQoL 5D-5L is used to assess patients' medication adherence and quality of life. This study involved a total of 74 Type 2 DM patients with an average age of 57 ± 10.74 years. Medication adherence with good blood sugar control (HbA1c <7%) showed a significant relationship (p-value <0.05) with COR values of 3.74 (1.21-11.6) compared to non-adherent patients. But not on the QoL Index and VAS (Visual Analog Scale) values, where the value is lower in patients with high adherence and good blood sugar control. Factor asscociated with blood sugar controlled were comorbidites and medication adhrence while factor that associated with quality of life were comorbidities, ages, education and employment status.
Background: The coronavirus that causes severe acute respiratory syndrome (COVID-19) is coronavir... more Background: The coronavirus that causes severe acute respiratory syndrome (COVID-19) is coronavirus 2 (SARS-CoV- 2). This virus has caused a global pandemic. The adverse impact of this virus in the past two years has resulted in efforts to build herd immunity through vaccination. This study aimed to identify the side effects after getting the Pfizer and Sinovac vaccines at the Universitas Indonesia Hospital and the risk factors for Adverse Events Following Immunization (AEFI).Methods: This observational study used a descriptive, non-experimental method with a cross-sectional design. Google Forms was used to collect data.Results: The onset of AEFI symptoms ranged from 15 minutes to 24 hours. The common AEFI symptoms were pain at the injection site, fatigue, muscle aches, and joint pain. The AEFI severity was mostly at the mild level, and only a few participants took medication. Female participants, participants with comorbidities and allergies, previous medication histories within th...
identify the profile of the effectiveness of Remdesivir (RDV) therapy and its relationship to blo... more identify the profile of the effectiveness of Remdesivir (RDV) therapy and its relationship to blood type variations in COVID-19 patients at Universitas Indonesia Hospital (RSUI).Methods: Variations in blood types were examined for their influence on the effectiveness in Covid-19 infected patients with RDV as an antiviral treatment. Data for this study were acquired at RSUI using a retrospective cross-sectional method. The sample is infected patients with COVID-19 from January 2021 to December 2021 who received RDV therapy. The parameters of the effectiveness of the treatment was a reduction of minimally 2 points on the WHO Clinical Progression Scale after 14 days of Remdesivir administration.Results: RDV effectiveness percentage shows 57.5% of patients experienced clinical improvement. The analysis results of the effect of blood type variations on clinical outcomes significantly affect the effectiveness of RDV therapy (OR: 1.705, 95% CI: 1.091–2.665; p = 0.019) but insignificant in ...
Edukasi menggunakan video dan kartu pengingat minum obat merupakan intervensi yang dapat dilakuka... more Edukasi menggunakan video dan kartu pengingat minum obat merupakan intervensi yang dapat dilakukan untuk meningkatkan kepatuhan penggobatan menuju keberhasilan terapi. Penelitian ini bertujuan untuk mengevaluasi edukasi menggunakan video dan kartu pengingat minum obat terhadap kepatuhan penggunaan antihipertensi pada pasien rawat jalan di Puskesmas Tangerang Selatan-Banten. Penelitian menggunakan rancangan Randomized Controlled Trial (RCT) dengan melibatkan 160 responden, terdiri dari kelompok kontrol (80 responden) dan intervensi (80 responden). Data Kepatuhan penggobatan dan tekanan darah terkontrol dinilai dari pengisian kuesioner Morisky Medication Adherence Scale (MMAS-8) dan rekam medik. Tingkat kepatuhan antar kelompok dianalisis menggunakan Uji Mann-Whitney sedangkan pengaruh intervensi dianalisis menggunakan Uji Wilcoxon. Sebelum Intervensi ada perbedaan signifikan antar kelompok mengenai karakteristik demografi responden, karakteristik klinis, dan gaya hidup. Intervesi apo...
Journal of Pharmaceutical Policy and Practice, Oct 12, 2022
Background: Medication adherence, one of the most important aspects in the process of optimal med... more Background: Medication adherence, one of the most important aspects in the process of optimal medicines use, is unfortunately still a major challenge in modern healthcare, and further research is required into how adherence can be assessed and optimised. The aim of this study was to use a combined method approach of self-report and dried blood spot (DBS) sampling coupled with population pharmacokinetic (PopPK) modelling, to assess adherence to metformin in adult patients with type 2 diabetes. Further aims were to assess metformin exposure levels in patients, determine factors associated with non-adherence with prescribed metformin, and to explore the relationship between adherence and therapeutic outcomes. Methods: A combined method approach was used to evaluate metformin adherence in patients with type 2 diabetes who had been prescribed metformin for a minimum period of 6 months. Patients were recruited from consultant-led diabetic outpatient clinics at three hospitals in Northern Ireland, UK. Data collection involved self-reported questionnaires [Medication Adherence Report Scale (MARS), Beliefs about Medicines Questionnaire and Centre for Epidemiologic Studies Depression Scale], direct measurement of metformin concentration in DBS samples, and researcher-led patient interviews. The DBS sampling approach was coupled with population pharmacokinetic (PopPK) modelling, which took account of patient characteristics, metformin dosage and type of formulation prescribed (immediate or sustained release). Results: The proportion of patients considered to be adherent to their prescribed metformin, derived from selfreported MARS scores and metformin concentration in DBS samples, was 61.2% (74 out of 121 patients). The majority (n = 103, 85.1%) of recruited patients had metformin exposure levels that fell within the therapeutic range. However, 17 patients (14.1%) had low exposure to metformin and one patient (0.8%) had undetectable metformin level in their blood sample (non-exposure). Metformin self-administration and use of a purchased adherence pill box significantly increased the probability of a patient being classified as adherent based on logistic regression analysis. Both HbA1c and random glucose levels (representing poor glycaemic control) in the present research were, however, not statistically linked to non-adherence to metformin (P > 0.05). Conclusions: A significant proportion of participating patients were not fully adherent with their therapy. DBS sampling together with the use of a published PopPK model was a useful, novel, direct, objective approach to estimate levels of adherence in adult patients with type 2 diabetes (61.2%).
Clinical profile, treatment, and outcomes of patients with COVID-19 in a tertiary referral hospital in South Sumatera, Indonesia: A retrospective single-center study
Belitung Nursing Journal
Background: Although there are fewer COVID-19 cases in Indonesia, the pandemic is still ongoing. ... more Background: Although there are fewer COVID-19 cases in Indonesia, the pandemic is still ongoing. COVID-19 has a significant death rate in Indonesia, but lack of information on the effect of different clinical and demographic factors on COVID-19-related grimness and mortality in Indonesia. Objective: This study examined the clinical profile, treatment, and outcomes of patients with COVID-19 at Lahat Regency Hospital in South Sumatera, Indonesia, to find relevant markers that might be utilized to predict the prognosis of these patients. Methods: This was a retrospective single-center study of all medical record files of confirmed patients with COVID-19 admitted to Lahat Hospital from September 2020 to August 2021 (n = 285). Descriptive statistics, Chi-square, Mann-Whitney, Multiple Logistic Regression, and Cox's proportional hazards model were used for data analyses. Results: This study included 65 non-hospitalized and 220 hospitalized patients. Hospitalized patients were divided ...
Pemerintah telah memberikan secara gratis hematinik yang mengandung 200 gram fero sulfat dan 0.25... more Pemerintah telah memberikan secara gratis hematinik yang mengandung 200 gram fero sulfat dan 0.25 gram asam folat sejak tahun 1970, namun prevalensi anemia pada pasien hamil di Puskesmas Kecamatan Matraman masih relatif tinggi. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang dapat memengaruhi efektivitas dari hematinik yang dikonsumsi oleh pasien hamil di Puskesmas Kecamatan Matraman. Metode penelitian menggunakan rancangan studi cross-sectional dengan teknik pengambilan data purposive sampling. Data diperoleh dari hasil pemeriksaan kadar hemoglobin pasien dan hasil wawancara pasien dengan menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya. Responden adalah pasien hamil yang mengonsumsi hematinik dari pemerintah dan telah melakukan pemeriksaan kadar hemoglobin minimal 2 kali. Jumlah sampel yang masuk kriteria inklusi pada penelitian sebanyak 85 pasien. Berdasarkan hasil penelitian, terdapat hubungan bermakna antara pengaruh kebiasaan konsumsi teh deng...
Background: Medication adherence is essential to achieving controlled blood sugar in diabetic pat... more Background: Medication adherence is essential to achieving controlled blood sugar in diabetic patients. Insulin generally provides better glycemic control but is considered painful and requires special techniques. Insulin administration in patients with neurological complications requires particular consideration because these complications can cause physical and cognitive barriers. Objective: This study analyses the effect of insulin administration on medication adherence in diabetic patients with neurological complications and the influence of various confounding variables (baseline characteristics, medical and medication history). Methods: This observational study was conducted with a cross-sectional design at a government hospital in East Jakarta from September 2021 to January 2022. The sample was type 2 diabetes mellitus patients with neurological complications who received antidiabetics for at least six months. The neurological complications include central nervous disorders (...
The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combi... more The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas sulfonylurea has been shown to reduce this impact. This study aimed to compare the impacts of metformin and metformin-sulfonylurea on cognitive function and determine what factors affected it. This cross-sectional study was conducted at Pasar Minggu Primary Health Care involving 142 type 2 diabetes mellitus patients taking metformin or metformin-sulfonylurea for > 6 months and aged > 36 years. Cognitive function was assessed using the validated Montreal Cognitive Assessment Indonesian version. The effects of metformin and metformin-sulfonylurea on cognitive decline showed no significant difference, even after controlling for covariates (aOR = 1.096; 95% CI = 0.523–2.297; p-value = 0.808). Multivariate analysis showed age (OR =...
Background Information about how newspapers portray antidiabetic medicines to readers is lacking.... more Background Information about how newspapers portray antidiabetic medicines to readers is lacking. This study investigated the reporting on antidiabetic medicines in the most widely circulated newspapers published in the United Kingdom (UK) and the United States (US) over a 10-year period. Methods The Nexis UK database was used to identify and select relevant articles. Systematic content analysis of the articles which met the inclusion criteria (articles of any format that contained reference to antidiabetic medicines) within the highest circulated newspapers in the UK and US between 2009 and 2018 was conducted. Inter-rater reliability of coding was established using a 10% sample of the identified articles. Results A total of 560 (369 UK and 191 US) relevant newspaper articles were retrieved. In the UK, the number of relevant articles showed a slightly increasing trend over the study period, while in the US, article numbers declined over the study period. Safety/risk of antidiabetic ...
Toksisitas hematologi regimen TAC dan FAC pada pasien kanker payudara di rumah sakit kanker dharmais jakarta. Analisis data rekam medik tahun 2007-2008
Pengaruh edukasi terhadap tingkat pengetahuan dan rasionalitas penggunaan obat swamedikasi pengunjung di dua apotek kecamatan Cimanggis, Depok = The influence of education on knowledge and rational drug use in self-medication of visitors at two pharmacies in Cimanggis Subdistrict, Depok
Penggunaan obat off label pada pasien hamil di instalasi rawat inap dan gawat darurat kebidanan kandungan RSUP Fatmawati periode Maret 2015 = Off label drug use in pregnant patients at inpatient unit and obstetric gynecology emergency unit Fatmawati Centre General Hospital March 2015 / Erisa Adel...
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