Papers by Niina Ronkainen
NTSC 1101 – An Experience for First-Year Students in the College of Science and Health at Benedictine University
ACS symposium series, Jun 18, 2024
InTech eBooks, Oct 19, 2016
InTech eBooks, May 31, 2017
Micro- and Nanoelectrodes in Protein-Based Electrochemical Biosensors for Nanomedicine and Other Applications
John Wiley & Sons, Inc. eBooks, Oct 10, 2015
Bioanalytical Chemistry and Chemical Sensors: An Advanced Elective Course for Undergraduates
Acs Symposium Series, 2013
Anti‐Proliferative Effects of Selected Dietary Polyphenols on Human Colon Carcinoma Cell Line, T84
The FASEB Journal, 2015
Polyphenols are naturally occurring compounds in plants which are typically involved in defense a... more Polyphenols are naturally occurring compounds in plants which are typically involved in defense against ultraviolet radiation or pathogens. Previous studies have shown that various polyphenols have anti-proliferative properties in a variety of human cancers. The purpose of this study is to determine the effect of Quercetin (QC), Epigallocatechin-3-gallate (EGCG), Catechin and Resveratrol (RVL) on cell death and apoptosis in human colon carcinoma, T84, cells. Cell death and apoptosis was measured by using Annexin V: FITC Apoptosis Detection Kit I and a flow cytometry. Short term (1 hour) and long term (overnight; O/N) effects were observed. Cells were grown in 6 well plates, serum starved O/N and treated with different concentrations of polyphenols for varying time. Linear Sweep Voltammetry (LSV) was used to electrochemically characterize the antioxidant capacity and to quantify active RVL and QC (the polyphenols acting as reducing agents) for the time frame of the study. While EGCG and Catechin did not ha...
Promoting the gradual development of process skills in analytical chemistry courses at a primarily undergraduate institution
Impact of course preparation assignments on student learning in chemistry and biochemistry courses
The evolution of 1st to 3rd generation electrochemical biosensors reflects a simplification and e... more The evolution of 1st to 3rd generation electrochemical biosensors reflects a simplification and enhancement of the transduction pathway. However, in recent years, modification of the transducer with nanomaterials has become increasingly studied and imparts many advantages. The sensitivity and overall performance of enzymatic biosensors has improved tremendously as a result of incorporating nanomaterials in their fabrication. Given the unique and favorable qualities of gold nanoparticles, graphene and carbon nanotubes as applied to electrochemical biosensors, a consolidated survey of the different methods of nanomaterial immobilization on transducer surfaces and enzyme immobilization on these species is beneficial and timely. This review encompasses modification of enzymatic biosensors with gold nanoparticles, carbon nanotubes, and graphene.
Electrochemical Sensors Technology, 2017
Glutamate, a major excitatory neurotransmitter in the mammalian central nervous system, plays a v... more Glutamate, a major excitatory neurotransmitter in the mammalian central nervous system, plays a vital role in many physiological processes and is one of the key neurotransmitters of interest in psychopharmacology. It is involved in many normal and abnormal behaviors related to neurological and psychiatric disorders. The glutamate system has been proposed to play a significant role in various neurological and psychiatric disorders such as Alzheimer's disease, autism, schizophrenia, depression, drug addiction, and more. The design, construction, and optimization of enzyme-based electrochemical biosensors for in vivo and in vitro detection of glutamate are active areas of interdisciplinary research. For example, various glutamate biosensors have been developed for monitoring dynamic levels of extracellular glutamate in the living brain tissue adding to the current medical knowledge of these complex neurotransmitter systems and ultimately impacting treatment plans. In addition to biological sciences and clinical medicine, glutamate biosensors have been used in environmental monitoring, in the fermentation industry, and in the food industry for determination of monosodium glutamate (MSG), a common flavor-enhancing food additive.
Grape and Wine Biotechnology, 2016
The chapter will outline the basic theory, advantages and disadvantages, experimental considerati... more The chapter will outline the basic theory, advantages and disadvantages, experimental considerations and set up of various atomic spectroscopy, and electroanalytical quantification methods and their specific application to trace element determination in wines. The reader will gain an introduction to most popular elemental analysis methods used in beverage analysis. Copper, iron, manganese, and zinc will be used as examples of essential trace elements throughout the chapter that at high levels may affect the properties of wine as well as the sensory experience of the consumer. Furthermore, special considerations that should be given to wine as a sample matrix for quantitative analysis of inorganic elements and the use of standard addition methods will be described.
Bioanalytical Chemistry and Chemical Sensors: An Advanced Elective Course for Undergraduates
ACS Symposium Series, 2013
Micro- and Nanoelectrodes in Protein-Based Electrochemical Biosensors for Nanomedicine and Other Applications
Tiwari/Advanced, 2015
Integrating current scientific research topics and literature into Analytical Chemistry courses at a Primarily Undergraduate Institution
Lumat: International Journal of Math, Science and Technology Education, 2015
Studies have shown that the more ownership students take of their academic work, the greater the ... more Studies have shown that the more ownership students take of their academic work, the greater the level of information retained, knowledge acquired, and general cognitive development. Many teaching techniques that span across sciences, and go beyond standard techniques such as: merely lecturing at students or following written procedures for “cook book-style” laboratory experiments, have surfaced in the last decade. One such method, known as Course Preparation Assignments (CPAs), requires students to read and analyze course material prior to attending class. This approach gives students their first exposure to new content outside of the classroom, while also engaging them in responding to a series of questions that they must answer individually. This prior exposure to course material allows the students to not only complete written assignments with the incentive of earning points, but also forces them to reflect on what they are learning. Prior to adopting the CPA teaching practice, ...
Materials, 2014
Nanotechnology has played a crucial role in the development of biosensors over the past decade. T... more Nanotechnology has played a crucial role in the development of biosensors over the past decade. The development, testing, optimization, and validation of new biosensors has become a highly interdisciplinary effort involving experts in chemistry, biology, physics, engineering, and medicine. The sensitivity, the specificity and the reproducibility of biosensors have improved tremendously as a result of incorporating nanomaterials in their design. In general, nanomaterials-based electrochemical immunosensors amplify the sensitivity by facilitating greater loading of the larger sensing surface with biorecognition molecules as well as improving the electrochemical properties of the transducer. The most common types of nanomaterials and their properties will be described. In addition, the utilization of nanomaterials in immunosensors for biomarker detection will be discussed since these biosensors have enormous potential for a myriad of clinical uses. Electrochemical immunosensors provide a specific and simple analytical alternative as evidenced by their brief analysis times, inexpensive instrumentation, lower assay cost as well as good portability and amenability to miniaturization. The role nanomaterials play in biosensors, their ability to improve detection capabilities in low concentration analytes yielding clinically useful data and their impact on other biosensor performance properties will be discussed. Finally, the most common types of electroanalytical detection methods will be briefly touched upon.
Materials, 2014
Nanotechnology has played a crucial role in the development of biosensors over the past decade. T... more Nanotechnology has played a crucial role in the development of biosensors over the past decade. The development, testing, optimization, and validation of new biosensors has become a highly interdisciplinary effort involving experts in chemistry, biology, physics, engineering, and medicine. The sensitivity, the specificity and the reproducibility of biosensors have improved tremendously as a result of incorporating nanomaterials in their design. In general, nanomaterials-based electrochemical immunosensors amplify the sensitivity by facilitating greater loading of the larger sensing surface with biorecognition molecules as well as improving the electrochemical properties of the transducer. The most common types of nanomaterials and their properties will be described. In addition, the utilization of nanomaterials in immunosensors for biomarker detection will be discussed since these biosensors have enormous potential for a myriad of clinical uses. Electrochemical immunosensors provide a specific and simple analytical alternative as evidenced by their brief analysis times, inexpensive instrumentation, lower assay cost as well as good portability and amenability to miniaturization. The role nanomaterials play in biosensors, their ability to improve detection capabilities in low concentration analytes yielding clinically useful data and their impact on other biosensor performance properties will be discussed. Finally, the most common types of electroanalytical detection methods will be briefly touched upon.
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Papers by Niina Ronkainen