ABCL-265: Detection of Triple Protein Expression in Diffuse Large B-Cell Lymphoma (DLBCL): A Single-Center Study
Clinical Lymphoma, Myeloma & Leukemia, 2021
Background DLBCL is the most common type of NHL. Genetic studies have revealed that one molecular... more Background DLBCL is the most common type of NHL. Genetic studies have revealed that one molecular subtype that is resistant to treatment by standard protocols occurs when there are concurrent translocations in the c-Myc, BCL-2, and BCL-6 genes. Objective Our study aimed to detect the presence of triple protein expression in patients diagnosed with DLBCL at the Clinical Oncology Department in Menoufia University Hospital. We also aimed to explore the possible associations between c-Myc, BCL-2, and BCL-6 co-expression (TEL) and clinical, as well as epidemiological, data of included patients. Patients and Methods A tissue microarray platform was constructed using cores from selected areas of each specimen. 2-mm-diameter cores were duplicated and spaced 0.2 mm apart. Several four-micron-thick sections were prepared from blocks. Hematoxylin and eosin slides were reviewed to confirm pathological diagnosis according to criteria defined by WHO, and immunohistochemistry was used for the dete...
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Papers by Mohamed Alaa