Papers by Matthew Solomon
Old-Time Movies
Orson Welles in Focus
Open Forum Infectious Diseases, 2021
Background HIV-1 transmitted drug resistance (TDR) remains a global challenge that can impact car... more Background HIV-1 transmitted drug resistance (TDR) remains a global challenge that can impact care, yet its comprehensive assessment is limited and heterogenous. We longitudinally characterized statewide TDR in Rhode Island. Methods Demographic and clinical data from treatment-naïve individuals were linked to protease, reverse transcriptase and integrase sequences, routinely obtained over 2004–2020. TDR extent, trends, impact on 1 st-line regimens, and association with transmission networks were assessed using Stanford Database, Mann-Kendall statistic, and phylogenetic tools. Results In 1,123 individuals, TDR to any antiretroviral increased from 8% (2004) to 26% (2020), driven by NNRTI (5-18%), and less NRTI TDR (2-8%). Dual- and triple-class TDR were low and major InSTI resistance was absent. Predicted intermediate-high resistance was in 77% of those with TDR, with differential suppression patterns. Among all individuals, 34% were in molecular clusters, some only with members with ...
Cureus, 2020
Implanted artificial pacemakers are groundbreaking pieces of technology that have a vast array of... more Implanted artificial pacemakers are groundbreaking pieces of technology that have a vast array of medical benefits. However, as with other electronic devices, these implanted cardiac devices are not immune to failure. One of the most common failures are lead fractures, which can lead to conduction issues that result in inappropriate or insufficient electrical stimulation to the myocardium or other myocytes. The authors present a classic example of this type of artificial pacemaker failure, with the hospital course of a female patient presenting with erratic muscle contractions due to improper electrical impulse generation and conduction.
Cureus, 2020
The authors present a case of a 54-year-old male who presented to the ED with Stevens Johnson syn... more The authors present a case of a 54-year-old male who presented to the ED with Stevens Johnson syndrome (SJS) beginning on his upper lips, then spreading to his glans penis, airway, and buttocks. After using trimethoprim-sulfamethoxazole (TMP-SMX) to treat a pilonidal cyst diagnosed seven days prior to presentation, the patient began to have desquamating lesions on his upper and lower lips. Subsequently, he noticed desquamation on the glans penis and then between his buttocks. Before being referred to dermatology, he was treated with a high dosage of corticosteroids.
Journal of Vascular Surgery, 2019
Objective: The neutrophil-lymphocyte ratio (NLR) is an inexpensive and useful inflammatory marker... more Objective: The neutrophil-lymphocyte ratio (NLR) is an inexpensive and useful inflammatory marker that incorporates the balance of the innate (neutrophil) and adaptive (lymphocyte) immune responses. Data exist on the predictive value of the NLR for mortality in various coronary diseases and cancer surgery, but there is a paucity of data on the impact of preoperative NLR on vascular surgical outcomes. The aim of this study was to determine whether preoperative NLR is associated with elective endovascular aneurysm repair (EVAR) outcome. Methods: A retrospective review of all patients who underwent elective EVAR at a single institution between 2010 and 2017 was conducted (n ¼ 294). Only patients who had a preoperative complete blood count with differential were included. The preoperative NLR was computed by dividing absolute neutrophil count by absolute lymphocyte count. A receiver operating characteristic curve was used to determine the optimal cutoff value of NLR that was most predictive of mortality. NLR was therefore dichotomized so that patients with NLR above the threshold were at increased risk of mortality compared with those below it. Continuous variables were analyzed using Wilcoxon nonparametric signed rank test, and categorical variables were analyzed with Fisher exact test. A comparison of NLR and mortality was completed using Kaplan-Meier analysis. Results: Overall, 101 patients were included in this study. An NLR of $4.5 was noted to be predictive of increased mortality (P ¼ .001; Table ). Twenty-nine patients composed the high-NLR group (NLR $4.5) and the remaining 72 patients the low-NLR group (NLR <4.5). Baseline characteristics were similar between groups, except for a higher frequency of smoking history in the low-NLR group (90.3% vs 72.4%; P ¼ .03). At a mean of 29 months of follow-up, the overall mortality rate was 36.6%.
The Work of the Artist and His Lawyers in an Age of Technological Reproducibility
The Gold Rush, 2015
The Total Film-Maker
The Gold Rush, 2015
An Unstable Text
The Gold Rush, 2015
Historical Referents
The Gold Rush, 2015
Origins and Originality
The Gold Rush, 2015
A Northern Comedy
The Gold Rush, 2015
Addiction biology, Jan 7, 2016
Proinflammatory activity has been postulated to play a role in addictive processes and stress res... more Proinflammatory activity has been postulated to play a role in addictive processes and stress responses, but the underlying mechanisms remain largely unknown. Here, we examined the role of interleukin 1 (IL-1) and tumor necrosis factor-α (TNF-α) in regulation of voluntary alcohol consumption, alcohol reward and stress-induced drinking. Mice with a deletion of the IL-1 receptor I gene (IL-1RI KO) exhibited modestly decreased alcohol consumption. However, IL-1RI deletion affected neither the rewarding properties of alcohol, measured by conditioned place preference (CPP), nor stress-induced drinking induced by social defeat stress. TNF-α signaling can compensate for phenotypic consequences of IL1-RI deletion. We therefore hypothesized that double deletion of both IL-1RI and TNF-1 receptors (TNF-1R) may reveal the role of these pathways in regulation of alcohol intake. Double KOs consumed significantly less alcohol than control mice over a range of alcohol concentrations. The combined d...
Supporting The Parent/Child Bond Through an Attachment Based Framework in the Playgroup Context
Women of Early Cinema
Framework, Oct 1, 2004
Women of Early Cinema A Feminist Reader in Early Cinema, edited by Jennifer M. Bean and Diane Neg... more Women of Early Cinema A Feminist Reader in Early Cinema, edited by Jennifer M. Bean and Diane Negra, Duke University Press, 2002. Unlike previous anthologies on early cinema that have focused on the first decade or two of film history, A Feminist Reader in Early Cinema takes a longer and more inclusive view of the period. Films considered here span the entire silent era, from Alice Guy-Blache's La fee aux choux/The Cabbage Fairy (France, 1896)-sometimes identified as the first entirely fictional film-to Yinmu yanshi/An Amorous History of the Silent Screen (Zhang Shichuan, China, 1931), a reflexive melodrama of the Shanghai film industry. Editor Jennifer Bean explains, "By choosing to employ 'early cinema' as a term more or less coextensive with silent cinema," the collection emphasizes that the far-reaching transformations of early film history do not simply end at some point in the 1910s, or entirely with the coming of sound. Together, the twenty-one essays in this thick volume make for an intriguing and eclectic exploration of women's roles during the first thirty-five years of international cinema. The book breaks new ground with original contributions on previously unknown subjects and fresh approaches to somewhat more familiar topics. Extending the period of "early cinema" forces one to contemplate the historical diminution of women's authority in film production. By the early 1930s, Dorothy Arzner stood as one of a handful of exceptions to the unwritten rule of the male director, yet this book reminds us that such glaring gender inequity had not always been the case in film industries around the world. Guy-Blache, who is the subject of two essays, supervised all of Gaumont's film productions until 1907, then numerous others for the Solax Company she founded in New York in 1910. "In fact, she was responsible for the production of more than seven hundred films," Amelie Hastie reports, "most of which have also disappeared." Another prominent female producer-director of the teens receiving attention is Lois Weber. Constance Balides and Shelley Stamp discuss the relationship between Weber's Shoes (U.S.A., 1916), Where Are My Children? (U.S.A., 1916), The Hand That Rocks the Cradle (U.S.A., 1917), and Progressiveera social movements to reform working conditions and birth control. Many more women headed their own production companies prior to the consolidation of the studio system and its relatively strict division of labor. In the United States, female entrepreneurs like LuIe Warrenton, Gene Gauntier, Cleo Madison, Mabel Normand, and others combined producing with directing, performing, writing, and/or editing. Jane Gaines comments, "The existence of so many companies points, if nothing else, to the numerical importance of women at this stage and yet this knowledge has yet to have an influence on the film history we are teaching." The film history that is taught is largely a product of the film histories that have been written, and one hopes that A Feminist Reader in Early Cinema will have an impact in both areas. Various essays draw attention not only to women who worked behind the camera, but also to the astonishing spectrum of roles women took in front of the camera. Angela Dalle Vacche introduces us to the Amazonian Astrea, who abandoned the Venetian aristocracy to perform in the circus and cinema, where she was paired with a much smaller man in a series of Italian action comedies. Dalle Vacche contrasts Astrea's grotesque physicality with the arabesque movements of Italian film divas and early twentieth-century aviators, tracing a series of intriguing intersections between futurism, fashion, fiction, and flying in early Italian film culture. An interest in coming to terms with cinema's capacity to showcase movement is also taken up by Lori Landay, who focuses on the flapper films of Colleen Moore, Joan Crawford, and Clara Bow. Turning a perceptive eye to such films as Our Dandng Daughters (Harry Beaumont, U. …
Rapid Prototyping Microfluidic Devices Using Polyurethane
There is frequently a need to rapidly evolve designs for microfluidic structures in a cost effect... more There is frequently a need to rapidly evolve designs for microfluidic structures in a cost effective way, particularly during the research and development phase of product development. Cast polyurethane (PU) is an attractive material for such uses being available with a range of stiffness, from a soft elastomer through to rigid forms. Often the cured form of the PU is post-machinable allowing the designer to introduce additional features to the fluidic structure using laser machining or micro-milling. Features with micron resolution can be easily created in the bulk material with the correct choice of PU and machining method. The rapid prototyping of a microfluidic biodiagnostic device is described providing detail of the processes used to create a complex mold, and the resulting polyurethane devices produced. In particular, a staggered herringbone mixer structure within the device is described along with the resulting evaluation method. Accurate replication was achieved and mixing performance agreed with popular models.
Systems and methods for a sample fluid collection device
Stereocontrolled syntheses of C-linked deoxyribosides of 2-hydroxypyridine and 2-hydroxyquinoline
Tetrahedron Letters, 1991
Abstract 2′-Deoxy-C-ribosides 45 were prepared in optically active form by a route expected to be... more Abstract 2′-Deoxy-C-ribosides 45 were prepared in optically active form by a route expected to be generally us for the synthesis of the α- or β-anomers of 2′-deoxy-C-ribosides. Key steps are the addition of an organometallic reagent to aldehyde 7 , mesylation of the resulting alcohol, and stereospecific deprotection/cyclization to yield the 2′-deoxy-C-riboside ( 7+8 → 9/10;9 → 11 ).
Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 2009
A biosensor system for medical diagnostics based around resonant MEMS sensor technology is presen... more A biosensor system for medical diagnostics based around resonant MEMS sensor technology is presented in this paper. The working principle of the bioMEMS device is introduced and the functionalisation strategies for cancer marker recognition are described. In addition, the successful packaging and integration of functional MEMS biosensor devices are reported herein. This ongoing work represents one of the first hybrid assemblies to integrate a PCB packaged silicon MEMS device into a disposable microfluidic device.
Diabetes Technology & Therapeutics, 2012
Background: Postmarketing reports have linked exenatide use with acute pancreatitis and pancreati... more Background: Postmarketing reports have linked exenatide use with acute pancreatitis and pancreatic cancer, but a definitive relationship has yet to be established. Subjects and Methods: We conducted a retrospective cohort analysis of patients with type 2 diabetes with employer-provided health insurance from 2007 to 2009. Multivariate models estimated the association between exenatide use and acute pancreatitis and pancreatic cancer. We required at least 1 year of exenatide exposure in the pancreatic cancer analysis. Sensitivity analyses were conducted that quasirandomized exenatide use based on patient out-of-pocket costs. Results: Among 268,561 patients included in the acute pancreatitis analysis, only 2.6% used exenatide. Hospitalization for acute pancreatitis was rare (0.247% of patients). In unadjusted and adjusted analyses, patients who did not use exenatide were more likely to be hospitalized for acute pancreatitis (0.249% vs. 0.196% in unadjusted analysis), but the difference was not statistically significant in either analysis (P = 0.22 and P = 0.70, respectively). Among 209,306 patients in the pancreatic cancer analysis, 0.070% were diagnosed with pancreatic cancer, and 0.88% had at least 1 year of continuous exenatide exposure prior to the diagnosis. Those with exenatide exposure had higher rates of pancreatic cancer compared with those without (0.081% vs. 0.070% in unadjusted analysis). In both unadjusted and adjusted analyses, the difference was not statistically significant (P = 0.80 and P = 0.46, respectively). In sensitivity analyses, results were similar. Conclusions: We found no association between exenatide use and either hospitalization for acute pancreatitis or pancreatic cancer in a large sample of privately insured U.S. patients.
Fabrication of multilayered microfluidic 3D polymer packages
Proceedings Electronic Components and Technology, 2005. ECTC '05.
The realization of microfluidic packages by stacking and bonding several layers of microstructure... more The realization of microfluidic packages by stacking and bonding several layers of microstructured polymer films opens up the potential of creating complex three-dimensional microfluidic structures based on relatively simple two-dimensional manufacturing processes. Whereas a multitude of microstructuring techniques have been developed, packaging and bonding technologies for multilayer microfluidic devices are still underrepresented. Bulk bonding processes like thermal diffusion bonding fit
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Papers by Matthew Solomon