Papers by Maria Fernanda Martinez
Genetics of Alzheimer's disease
Essays in Biochemistry, Feb 1, 1998
Some observations on the cytology in Ochna sp (Ochnaceae)
Cytologia, 1992
Teaching methodology for the utilization of cinema in the teaching of medical microbiology and infectious diseases
Summary Cinema, since it's beginning, has been an... more Summary Cinema, since it's beginning, has been and is a social thermometer of the first magnitude reflecting the inequities of the population, among them are infectious diseases. The caudal of images, sounds, and feelings that appear in the field support a very valid teaching resource, capable of complementing the classic teaching method and adapting the dynamic art of teaching to
Stimulation of Microsomal Cholesterol Ester Hydrolase by Glucagon, Cyclic AMP Analogues, and Vasopressin in Isolated Rat Hepatocytes
Lipids, 1996
Short-term activation of microsomal cholesterol ester hydrolase by glucagon, cAMP analogues, and ... more Short-term activation of microsomal cholesterol ester hydrolase by glucagon, cAMP analogues, and vasopressin in isolated rat hepatocytes is described. Glucagon led to a dose- and time-dependent activation of cholesteryl oleate hydrolysis, but values returned to basal levels within 120 min. Exposure of isolated hepatocytes to 0.5 mM concentrations of dibutyryl-cAMP or 8-[4-chlorophenylthio]-cAMP, or 25 microM forskolin caused persistent activation of cholesterol ester hydrolase activity after a lag period of 30 min. The three agents resulted in early marked intracellular accumulation of cAMP that declined progressively, and moderate and sustained reductions in the diacylglycerol content. The actions of glucagon on hepatocytes were inhibited by pretreatment of cells with 10 nM [8-arginine] vasopressin. Vasopressin elicited a consistent and sustained increase in cholesterol ester hydrolase activity and diacylglycerol without affecting cAMP while reducing the effect of glucagon on cAMP. Furthermore, the effects of glucagon and vasopressin on the activation of cholesterol ester hydrolase were not additive despite the similarity of their stimulation of diacylglycerol formation. Blockade of vasopressin-mediated activation of cholesterol ester hydrolase and diacylglycerol content were induced by excess prazosin. These data suggest that stimulation of microsomal cholesterol ester hydrolase in isolated liver cells may involve at least two signal transduction systems.
Carcinogenesis, Mar 1, 2009
Diets high in red meat have been consistently associated with colorectal cancer (CRC) risk and ma... more Diets high in red meat have been consistently associated with colorectal cancer (CRC) risk and may result in exposure to carcinogens that cause DNA damage [i.e polycyclic aromatic hydrocarbons, heterocyclic amines (HCAs) and N-nitroso compounds]. Using a family-based study, we investigated whether polymorphisms in the nucleotide excision repair (NER) (ERCC1 3# untranslated region (UTR) G/T, XPD Asp312Asn and Lys751Gln, XPC intron 11 C/A, XPA 5# UTR C/T, XPF Arg415Gln and XPG Asp1104His) and mismatch repair (MLH1 Ile219Val and MSH2 Gly322Asp) pathways modified the association with red meat and poultry intake. We tested for gene-environment interactions using case-only analyses (n 5 577) and compared the results using case-unaffected sibling comparisons (n 5 307 sibships). Increased risk of CRC was observed for intake of more than or equal to three servings per week of red meat [odds ratio (OR) 5 1.8, 95% confidence interval (CI) 5 1.3-2.5)] or hightemperature cooked red meat (OR 5 1.6, 95% CI 5 1.1-2.2). Intake of red meat heavily brown on the outside or inside increased CRC risk only among subjects who carried the XPD codon 751 Lys/Lys genotype (case-only interaction P 5 0.006 and P 5 0.001, respectively, for doneness outside or inside) or the XPD codon 312 Asp/Asp genotype (case-only interaction P 5 0.090 and P < 0.001, respectively). These interactions were stronger for rectal cancer cases (heterogeneity test P 5 0.002 for XPD Asp312Asn and P 5 0.03 for XPD Lys751Gln) and remained statistically significant after accounting for multiple testing. Case-unaffected sibling analyses were generally supportive of the case-only results. These findings highlight the possible contribution of diets high in red meat to the formation of lesions that elicit the NER pathway, such as carcinogen-induced bulky adducts.
Identification and synthesis regulation of the main exopolysaccharide compound of the biofilm matrix of Salmonella enterica
The American Journal of Clinical Nutrition, Feb 1, 2006
Background: Evidence for an association between dietary fiber and colorectal neoplasia has been e... more Background: Evidence for an association between dietary fiber and colorectal neoplasia has been equivocal, and some data suggest that there may be sex differences in response to fiber. Objective: We sought to determine whether fiber affects colorectal adenoma recurrence differently in men and women by combining the study populations of 2 large clinical intervention trials: the Wheat Bran Fiber Trial and the Polyp Prevention Trial. Design: Data from 3209 participants combined from 2 trials were analyzed with logistic regression models to examine the effect of a dietary intervention on colorectal adenoma recurrence in the pooled population as a whole and by sex. Results: The adjusted odds ratio for adenoma recurrence for those in the intervention group of either the Wheat Bran Fiber Trial or the Polyp Prevention Trial was 0.91 (95% CI: 0.78, 1.06). For men, the intervention was associated with statistically significantly reduced odds of recurrence with an odds ratio of 0.81 (95% CI: 0.67, 0.98); for women, no significant association was observed. Using a likelihood-ratio test, we found a statistically significant interaction between intervention group and sex (P ҃ 0.03).
Cancer Epidemiology Biomarkers Prevention, Oct 1, 2003
Colorectal adenomatous polyps are considered to be the precursor lesion of colorectal cancer (1-3... more Colorectal adenomatous polyps are considered to be the precursor lesion of colorectal cancer (1-3). Greater understanding of the association between smoking and adenoma development enable better detection and prevention of colorectal cancer. This study was conducted in men and women, ages 40 -80, participating in a randomized trial testing the effects of wheat bran fiber supplement on adenoma recurrence. First, we investigated smoking exposure (status, cigarettes/day, and years of smoking) and colorectal adenoma characteristics (location, histology, size, and multiplicity) at baseline colonoscopy (n ؍ 1429). Second, we evaluated smoking exposure and adenoma recurrence (n ؍ 1304). The prevalence of distal versus proximal adenomas was greater for <30 cigarettes/day [odds ratio (OR), 1.48; 95% CI, 1.02-2.16] and 15 to <25 years of smoking (OR, 1.95; 95% CI, 1.23-3.09) compared with never smokers. Tubular versus villous histology prevalence was increased for >30 cigarettes and >35 years of smoking (OR, 1.74; 95% CI, 1.21-2.49 and OR, 1.74; 95% CI, 1.24 -2.45, respectively) compared with never-smokers. Years of smoking increased prevalence of multiple versus single adenomas, whereas cigarettes/day and years of smoking were associated with large adenomas (>1 cm) prevalence as compared with small lesions (<0.5 cm). Greater than 35 years of smoking was significantly associated with an increased risk of adenoma recurrence (OR, 1.42; 95% CI, 1.01-1.98). These results suggest that the association between smoking and adenoma prevalence varies by the characteristic of the lesion. Furthermore, the association between smoking and adenoma recurrence is modest and was only significant after a long duration of exposure. Additional investigations that characterize the genetic changes in specific subgroups of prevalent and recurrent adenomas associated with smoking exposure are needed. Downloaded from the complicated relationship between smoking exposure, adenomas, and colorectal cancer risk.
Cefalea numular:: características clínicas y experiencia terapéutica en una serie de 30 nuevos casos
Revista De Neurologia, 2011
Immobilization of pycnoporus coccineus laccase on Eupergit C: Stabilization and treatment of olive oil mill wastewaters
Biocatalysis and Biotransformation, 2007
... Jimmy Berrio 1 , Francisco J. Plou 2 , Antonio Ballesteros 2 ... Aggelis G, Iconomou D, Chris... more ... Jimmy Berrio 1 , Francisco J. Plou 2 , Antonio Ballesteros 2 ... Aggelis G, Iconomou D, Christou M, Bokas D, Kotzailias S, Christou G, Tsagou V, Papanikolaou S. Phenolic removal in a model olive oil mill wastewater using Pleurotus ostreatus in bioreactor cultures and biological ...
Cad Saude Publica, 2009
The Brazilian electric utility sector has recently undergone major industrial restructuring, with... more The Brazilian electric utility sector has recently undergone major industrial restructuring, with impacts on working conditions and work organization that could jeopardize the capacity for work. This study aimed to evaluate factors associated with labor capacity in a sample of 475 workers from an electric utility company in the State of São Paulo, Brazil. This cross-sectional study included descriptive and multiple linear regression analyses. The mean labor capacity index (LCI) was 41.8 points (on a scale from 7.0 to 49.0). Multiple regression showed that the factors that best explained LCI variability were work stress (p < 0.001) and physical health (p < 0.001 in all the dimensions). In a separate analysis, excluding all the health dimensions, the variables associated with LCI were work stress (p < 0.001), workplace (p = 0.022), physical activity (p = 0.001), alcohol consumption (p = 0.012), and body mass index (p < 0.001). The results highlighted aspects to be considered when developing measures to protect labor capacity, with an emphasis on stress prevention and health promotion.
M�thodes statistiques pour identifier les g�nes dans les maladies multifactorielles
The Fruit Export Sector in Lebanon. The Challenge of Conforming to Sanitary and Phytosanitary Measures
Cancer Research, Jul 1, 2003
The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the majority of c... more The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the majority of cancers overexpressing COX-2; however, the role of COX-2 in the development of colorectal adenomas is less well defined. Accordingly, we analyzed 108 colorectal adenomas for COX-1 and COX-2 transcription in archival formalin-fixed, paraffin-embedded tissue using by real-time PCR and normalized to -actin. Neither COX-1 nor COX-2 mRNA expression differed with regard to age or gender of the subject. COX-2 mRNA expression was significantly higher in distal adenomas (2.2 ؎ 1.9) compared with proximal (0.7 ؎ 0.5) adenomas (P < 0.0001) and in larger (>7 mm) compared with smaller (<7 mm) adenomas (2.3 ؎ 2.2 and 1.7 ؎ 1.3, respectively, P ؍ 0.04). COX-2 expression did not differ significantly in tubular compared with tubulovillous adenomas, although there appeared to be a trend toward higher COX-2 expression in tubulovillous adenomas with increasing villous content. Additionally, there was not a significant difference in either COX-1 or COX-2 based on the degree of dysplasia Therefore, if COX-2 inhibitors work through a COX-2 mechanism, these agents may have differential effects on colorectal adenomas that are distal and larger.
Cancer Causes and Control, May 1, 2002
Objective: Few data exist regarding the association between calcium intake and adenoma recurrence... more Objective: Few data exist regarding the association between calcium intake and adenoma recurrence, and no data exist for vitamin D. We investigated the role of dietary and supplemental sources of calcium and vitamin D in the etiology of adenoma recurrence. Methods: Analyses were conducted among 1304 male and female participants in the Wheat Bran Fiber (WBF) trial of adenoma recurrence. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: In the fully adjusted multivariate model, the OR for participants with dietary calcium intake above 1068 versus those with intake below 698 mg/day was 0.56 (95% CI ¼ 0.39-0.80; p-trend ¼ 0.007). Calcium supplementation at doses above 200 mg/day did not affect risk of recurrence. Although a borderline inverse association between dietary vitamin D and recurrence was observed after adjustment for age and gender, the association weakened in the fully adjusted model (OR ¼ 0.78 for individuals in the upper compared to the lower quartile; 95% CI ¼ 0.54-1.13). No association was shown for supplemental sources of vitamin D. Conclusions: Results of this study indicate that a higher intake of calcium decreases the risk of adenoma recurrence by approximately 45%, whereas vitamin D has no significant effect on recurrence rates.
Gestaci�n heterot�pica espont�nea. Diagn�stico ecogr�fico y tratamiento laparosc�pico
The American Journal of Clinical Nutrition, Apr 1, 2004
The results of epidemiologic studies indicate that higher intakes or blood concentrations of fola... more The results of epidemiologic studies indicate that higher intakes or blood concentrations of folate are associated with a lower risk of colorectal neoplasia; however, only one study assessed the role of homocysteine. Objective: We assessed the relation between biochemical and dietary markers of folate status and colorectal adenoma recurrence. Design: Analyses were conducted in 1014 men and women aged 40 -80 y who had undergone removal of all colorectal polyps. Diet and supplement use were ascertained through a food-frequency questionnaire administered at study entry. Blood collected at baseline was used to measure plasma folate and homocysteine concentrations. Unconditional logistic regression was used to assess the odds of recurrence associated with the intakes of folate, methionine, and vitamins B-6 and B-12 and with plasma folate and homocysteine. Results: Relative to subjects in the highest quartile of plasma homocysteine, those in the lowest quartile had an odds ratio (OR) of adenoma recurrence of 0.69 (95% CI: 0.47, 1.02; P for trend ҃ 0.02) after adjustment for confounding factors. Lower odds of recurrence were shown for higher plasma folate (OR: 0.66; 95% CI: 0.46, 0.97) and higher total intakes (dietary plus supplemental) of folate (OR: 0.61; 0.42, 0.89) and vitamin B-6 (OR: 0.65; 0.45, 0.94). Slightly weaker and nonsignificant associations were shown for dietary folate, methionine, and total vitamin B-12. Conclusions: A lower recurrence of colorectal adenomas was shown in subjects with higher intakes and plasma concentrations of folate. Additional markers involved in folate metabolism, including lower homocysteine and higher vitamin B-6 intake, were also associated with lower odds of recurrence.
Cancer Prevention Research, Mar 1, 2009
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Papers by Maria Fernanda Martinez