Synthesis and physicochemical characterization of a novel precursor for covalently bound macromolecular MRI contrast agents
JBIC Journal of Biological Inorganic Chemistry
The ligand DOTASA was designed and synthesized in the aim of obtaining a kinetically and thermody... more The ligand DOTASA was designed and synthesized in the aim of obtaining a kinetically and thermodynamically stable Gd(III) chelate which, through its uncoordinated carboxylate function, will provide an efficient pathway to couple the complex to bio- or macromolecules without affecting the coordination pattern of DOTA. Furthermore, it allows us to study the influence of an extra carboxylate arm on the
Structural and dynamic study of bis(tetraethyl pyrophosphite)pentacarbonyldiiron(Fe-Fe) and (tetraethyl pyrophosphite)heptacarbonyldiiron(Fe-Fe)
Inorganic Chemistry, 1978
Page 1. 2010 Inorganic Chemistry, Vol. 17, No. 7, 1978 Cotton et al. Contribution from the Depart... more Page 1. 2010 Inorganic Chemistry, Vol. 17, No. 7, 1978 Cotton et al. Contribution from the Departments of Chemistry, Texas A&M University, College Station, Texas 77843, and University of Natal, Pietermaritzburg, Natal, South Africa ...
High pressure NMR kinetics. 29. Variable-temperature, -pressure, and -frequency oxygen-17 NMR study of water exchange on hexaaquatitanium(III): a limiting associative mechanism?
Multinuclear NMR Studies of Ligand-Exchange Reactions on Analogous Technetium(V) and Rhenium(V) Complexes. Relevance to nuclear medicine
Helvetica Chimica Acta, Feb 5, 1992
... by Lothar Helma), Karen Deutschb), Edward A. Deutschb)*, and Andre E. Merbacha)')* "... more ... by Lothar Helma), Karen Deutschb), Edward A. Deutschb)*, and Andre E. Merbacha)')* " Institut de Chimie Minerale et Analytique, Place du Chlteau 3, CH-1005 Lausanne b, Biomedical Chemistry Research Center, Department of ... [2] K. Libson, L. Helm, A. Roodt, C. Cutler, AE ...
Two approaches to high-resolution high-pressure nuclear magnetic resonance
Journal of magnetic resonance, 1978
... irritating small drop in pressure due to a slight nonelastic deformation of the Vespel tube. ... more ... irritating small drop in pressure due to a slight nonelastic deformation of the Vespel tube. In studies of chemical kinetics, it is necessary to know the temperature of the sample accurately and more important, for volumes of activation, to know that the temperature 16 VANNI, EARL ...
Monocomplex formation and dissociation of some first row divalent transition metal ions with 2-chloro-1,10-phenanthroline by the high-pressure stopped-flow technique
Stopped-flow fourier-transform NMR and NMR line broadening studies of the rates of dimethyl sulphoxide exchange with the hexakis(dimethylsulphoxide) complexes of aluminium(III), gallium(III) ions in nitromethane solution
Inorganica Chimica Acta, 1980
... André E. Merbach and Peter Moore Corresponding Author Contact Information. Oliver W. Howarth ... more ... André E. Merbach and Peter Moore Corresponding Author Contact Information. Oliver W. Howarth and Colin H. McAteer. ... In: AE Martell, Editor, Co-ordination Chemistry 2, American Chemical Society (1978) ACS Monograph 174. 12. ...
ChemInform Abstract: ADDITIONSVERBINDUNGEN VON NIOB(V)- UND TANTAL(V)-HALOGENIDEN 4. MITT. BESTIMMUNG DER RELATIVEN STABILITAET VON 1 ZU 1-VERBINDUNGEN DER NB- UND TA-CHLORIDE MIT NITRILEN DURCH NMR-METHODEN
Five coordinate tetramethylcyclam complexes of Co(II) and Ni(II); associative interchange and dissociative mechanisms for solvent exchange in acetonitrile
1H-NMRD and17O-NMR assessment of water exchange and rotational dynamics of two potential MRI agents: MP-1177 (an extracellular agent) and MP-2269 (a blood pool agent)
Magnetic Resonance Materials in Physics Biology and Medicine, Aug 1, 1999
The parameters that govern water proton magnetic relaxation (e.g. water exchange rates, and rotat... more The parameters that govern water proton magnetic relaxation (e.g. water exchange rates, and rotational and electronic correlation times) of representatives of two classes of Gd(III) complexes have been estimated, using two different approaches and the results compared with those derived for known analogs. The complexes studied are: (i) the non-ionic GdDTPA-bis(-methoxyethyl-amide) [Gd(DTPA-BMEA)], a typical small-molecule extracellular MR agent, and (ii) the ionic Gd(III) complex of 4-pentylbicyclo[2.2.2]octane-1-carboxyl-di-L-aspartyl-lysine-deriv ed-DTPA [GdL]4-, a prototype MR blood pool agent, which binds to serum albumin in vivo through non-covalent hydrophobic interactions. An 17O-NMR study of [Gd(DTPA-BMEA)] gives a water exchange rate constant of k(ex)298 = (0.39 +/- 0.02) x 10(6) s(-1), identical to that for the bismethylamide analog [Gd(DTPA-BMA)]. Both approaches yield longer rotational correlation times for [Gd(DTPA-BMEA)], consistent with its higher molecular weight. An 17O-NMR study of [GdL]4- gives a water exchange rate constant of k(ex)298 = (4.2 +/- 0.1) x 10(6) s(-1), identical to that for [Gd(DTPA)]2-. The water exchange rate on [GdL]4- did not decrease considerably when bound to albumin, the lowest limit is k(ex,GdL-BSA) = k(ex,GdL)/2. Both approaches yield identical rotational correlation times for [GdL]4-, however, it was difficult to derive a consistent rotational constant for the albumin-bound [GdL]4- using the different approaches (values ranged between 1.0 and 23.0 ns).
Uploads
Papers by ANDRE MERBACH