Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal and paranasal mucosa (1), wh... more Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal and paranasal mucosa (1), which has been increasing in prevalence and incidence worldwide and affects between 4% and 28% of the population in the western countries (2, 3). Pathophysiological studies have indicated that CRS can be classified into two subgroups based on the absence (CRSsNP) or presence (CRSwNP) of nasal polyps, which have distinctive inflammatory cell and mediator profiles (4-7) and specific features of remodelling (8, 9). Earlier
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