Papers by Lane Desborough
1496-PUB: Augmenting Clinical Trial Data with In-Silico Evidence to Evaluate Initial Conversion Dose Changes for Technosphere Insulin (TI)
Diabetes
Background: TI is an inhaled mealtime insulin with ultra-rapid onset and short duration of action... more Background: TI is an inhaled mealtime insulin with ultra-rapid onset and short duration of action closely mimicking physiologic insulin. Clinical studies demonstrated a higher initial dose could result in faster titration to overcome a perceived lack of effect. The aim was to develop an in silico model to augment results of a study (NCT04849845) evaluating an increased initial conversion of TI from injected insulin vs. the current label in 20 adults with diabetes that showed significantly improved post-prandial control after 45 minutes. Methods: The in silico model characterizes blood glucose trends and outcomes utilizing published equations and distributions derived from real-world data sources. Inputs with the largest effects on glucose outcomes were combined to match study parameters to generate one million meal boluses. The model was validated using common modeling and simulation recommendations. Results: Model inputs were constrained to match clinical study parameters; in silic...
722-P: Inhaled Insulin Improves Daytime Time-in-Range in People with Type 2 Diabetes
Diabetes, 2021
IFAC Proceedings Volumes, 1997
Journal of diabetes science and technology, 2013
Despite advancements in the development of the artificial pancreas, barriers in the form of propr... more Despite advancements in the development of the artificial pancreas, barriers in the form of proprietary data and communication protocols of diabetes devices have made the integration of these components challenging. The Artificial Pancreas Standards and Technical Platform Project is an initiative funded by the JDRF Canadian Clinical Trial Network with the goal of developing device communication standards for the interoperability of diabetes devices. Stakeholders from academia, industry, regulatory agencies, and medical and patient communities have been engaged in advancing this effort. In this article, we describe this initiative along with the process involved in working with the standards organizations and stakeholders that are key to ensuring effective standards are developed and adopted. Discussion from a special session of the 12th Annual Diabetes Technology Meeting is also provided.
Indian Journal of Endocrinology and Metabolism, 2014
To describe the clinical profi le, maternal and fetal outcomes, and the conversion rates to diabe... more To describe the clinical profi le, maternal and fetal outcomes, and the conversion rates to diabetes in women with gestational diabetes mellitus (GDM) seen at a tertiary care diabetes center in urban south India. Materials and Methods: Clinical case records of 898 women with GDM seen between 1991 and 2011 were extracted from the Diabetes Electronic Medical Records (DEMR) of a tertiary care diabetes center in Chennai, south India and their clinical profi le was analyzed. Follow-up data of 174 GDM women was available. To determine the conversion rates to diabetes, oral glucose tolerance test (OGTT) was done in these women. Glucose tolerance status postpartum was classifi ed based on World Health Organization (WHO) 2006 criteria. Results: The mean maternal age of the women was 29 ± 4 years and mean age of gestation at fi rst visit were 24 ± 8.4 weeks. Seventy percent of the women had a family history of diabetes. Seventy-eight percent of the women delivered full-term babies and 65% underwent a cesarean section. The average weight gain during pregnancy was 10.0 ± 4.2 kg. Macrosomia was present in 17.9% of the babies, hypoglycemia in 10.4%, congenital anomalies in 4.3%, and the neonatal mortality rate was 1.9%. Mean follow-up duration of the 174 women of whom outcome data was available was 4.5 years. Out of the 174, 101 women who were followed-up developed diabetes, of whom half developed diabetes within 5 years and over 90%, within 10 years of the delivery. Conclusions: Progression to type 2 diabetes mellitus (T2DM) in Indian women with GDM is rapid. There is an urgent need to develop standardized protocols for GDM care in India that can improve the maternal and fetal outcomes and help prevent future diabetes in women with GDM.
Journal of Process Control, 1999
The Canadian Journal of Chemical Engineering, 1992
An analysis of variance for univariate feedforwardlfeedback systems has been derived which allows... more An analysis of variance for univariate feedforwardlfeedback systems has been derived which allows the variance contributions due to both disturbances and controllers to be established. A performance index which assesses the performance of the overall control scheme has been developed. Estimates of the analysis of variance and performance index can be obtained using ordinary closed loop data and least squares regression. These quantities can be used on-line or off-line for either the design of new controllers or as a means of assessing the performance of existing feedforwardlfeedback control schemes. The practicality of the results in the paper are demonstrated using simulated and industrial data. On a Ctabli une analyse de variance de systbmes actionlrktroaction univariCs qui permet l'ktablissement des contributions de la variance dues aux perturbations et aux contrbleurs. Un indice de performance Cvaluant la performance du schtma de contr6le global a Ct C calculk. I1 est possible d'obtenir des estimations de l'analyse de la variance et de I'indice de performance a l'aide des donntes en boucle fermCe habituelles et de regression des moindres carrCs. Ces quantitks peuvent Ctre utilisCes en ligne ou de manikre indbpendante soit pour la conception de nouveaux contr6leurs, soit comme moyen d'evaluer la performance des schkmas de contrble post-actionirCtroaction existants. L'applicabilitk de ces rCsultats est demontrCe 3 I'aide de donnkes simulCes et industrielles.
Biomedical Instrumentation & Technology, 2013
Web-enabled control loop assessment
Internet technology can be used to monitor and improve the performance of control loops by compar... more Internet technology can be used to monitor and improve the performance of control loops by comparing current status with best practices. This article explains how to implement the technique.
Control performance assessment: a method to diagnose loop problems is discussed
Cette communication consiste en une description des moyens d'evaluer le rendement d'une c... more Cette communication consiste en une description des moyens d'evaluer le rendement d'une commande par retroaction seulement et d'une combinaison commande/commande par retroaction au moyen de donnees d'exploitation courantes. Cette description est suivie d'une analyse de la variance qui decompose la variance du procede par perturbation et par systeme asservi, ce qui permet de comparer le rendement du systeme asservi existant a une norme de controle de variance minimum. Des donnees industrielles sont utilisees pour demontrer l'utilite de la methode decrite
AICHE symposium series, 2002
Within the process industries there is a significant installed base of regulatory and multivariab... more Within the process industries there is a significant installed base of regulatory and multivariable model predictive controllers. These controllers in many cases operate very poorly. This paper documents the current state of industrial controller performance, identifies the sources and ramifications of this poor performance, and discusses required attributes of a Process Control Monitoring System (PCMS). Finally, research directions are suggested.
Transforming Evidence Generation for Drug Label Changes: A Case Study
Annals of Biomedical Engineering
Uploads
Papers by Lane Desborough