Luca Fadini

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APLICACIÓN DE LÍQUIDOS IÓNICOS PARA LA HIDROAMINACIÓN HOMOGÉNEA DE OLEFINAS CATALIZADA POR COMPLEJOS DE Ni(II) IONIC LIQUID APPLICATION IN THE HOMOGENOUS HYDROAMINATION OF OLEFINS CATALYZED BY Ni(II) COMPLEXES APLICAÇÃO DO LÍQUIDOS IÓNICOS PARA A HIDROAMINAÇÃO HOMOGÊNEA DO OLEFINAS CATALIZADA POR...

Síntesis y Estudio Teórico DFT De Compuestos De Ru(II) Con Ligantes Ferrocenílicos Para Aplicaciones Electroquímicas Synthesis and Theoretical DFT Study of Ru(II) Complexes with Ferrocenylic Ligands for Electrochemical Applications Sintese e Estudo Teórico DFT De Compostos De Ru(II) Com Ligantes ...

Impact of Solvent and Their Contaminants on Pd/C Catalyzed Suzuki‐Miyaura Cross‐Coupling Reactions

Helvetica Chimica Acta, 2021

The aim of this work was to understand if solvent contaminants can interfere in Suzuki's cross-co... more The aim of this work was to understand if solvent contaminants can interfere in Suzuki's cross-coupling reactions and if it can explain the lack of robustness in industrial processes. For this purpose, several parameters were tested on the industrial model reaction between 2-bromonaphthalene and phenylboronic acid catalyzed by Pd/C. Best results were obtained using THF as solvent. Traces of the precursors of the used solvents, such as 2,3-dihydrofurane or maleic anhydride (100-300 ppm related to the solvent) strongly poisoned the reaction, decreasing the conversion significantly. This means that to ensure robust production, solvent quality must be analyzed at the ppm level. Fortunately, addition of triphenylphosphine can circumvent the catalyst poisoning.

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Substituierte 4-phenyl-pyridine zur behandlung von nk-1-rezeptor-vermittelten erkrankungen

Solution comprising the chloride hydrochloride salt of 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-IUM-(fosnetupitant) and palonosetron hydrochloride in combination with dexamethasone as a neurokinin receptor

Disclosed is a solution comprising the chloride hydrochloride salt of 4-(5-(2-(3,5-bis(trifluorom... more Disclosed is a solution comprising the chloride hydrochloride salt of 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium (fosnetupitant) and palonosetron hydrochloride in combination with dexamethasone and its application in methods for preventing acute and delayed nausea and vomiting in a human patient receiving highly emetogenic cancer chemotherapy.

Formes cristallines de fosnétupitant

La presente invention concerne des formes cristallines du sel de monochlorhydrate de chlorure de ... more

Inorganic Chemistry in Latin America

European Journal of Inorganic Chemistry, 2021

Sintese e Estudo Teórico DFT De Compostos De Ru(II) Com Ligantes Ferrocenilicos Para Aplicação Eletroquímica

Revista Colombiana De Quimica, Dec 1, 2007

Novel ruthenium(II) complexes with ferrocenylic and/or phosphinic ligands of the type [RuCl2(PP)(... more Novel ruthenium(II) complexes with ferrocenylic and/or phosphinic ligands of the type [RuCl2(PP)(NN)], with PP = 1,1’bis(diphenylphosphino)ferrocene (dppf) or 1,2-dipheylphospinoethane (dppe) and NN = 3,3’-dicarboxyl2,2’-bipyridine (3,3’dcbpy) or 2,2’-bipyridine (bpy) were synthesized and characterized. DFT studies of these compounds allowed to explain some experimental aspects, leading to a theoretical design of modified Ru(II) ferrocenylic complexes in order to be used as a 199 REVISTA COLOMBIANA DE QUIMICA, VOLUMEN 36, No. 2 DE 2007 A p lic ad a y A n al it ic a 1 Departamento de Quimica, Facultad de Ciencias, Universidad Nacional de Colombia, sede Bogota, Bogota, Colombia. lfadini@unal.edu.co dye for Photosensitized Solar Cells. The ligands and the complexes were characterized by H y P – NMR, UV-Vis, IR and Cyclic and differential pulse voltammetries.

COMPLEXES APLICAÇÃO DO LÍQUIDOS IÓNICOS PARA A HIDROAMINAÇÃO HOMOGÊNEA DO OLEFINAS CATALIZADA POR COMPOSTOS DE Ni(II)

Revista Colombiana De Quimica, Dec 1, 2008

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Substituted 4-phenyl pyridines having anti-emetic effect

Substituted 4-PHENYL-PYRIDINES

Nicke(II)-Catalyzed Highly Enantioselective Hydrophosphination of Methacrylonitrile

Journal of the American Chemical Society Jacs, 2004

Methods of treating emesis

Modified 4-PHENYL-PYRIDINE Derivatives

Electrochemical Oxidation of Hydrogen on Basal Plane Platinum Electrodes in Imidazolium Ionic Liquids

The Journal of Physical Chemistry C, 2011

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Nickel(II)-Catalyzed Highly Enantioselective Hydrophosphination of Methacrylonitrile

Journal of the American Chemical Society, 2004

Chiral phosphines, as ligands in transition metal complexes, efficiently create asymmetric cataly... more Chiral phosphines, as ligands in transition metal complexes, efficiently create asymmetric catalysts for enantioselective transformations. 1 However, chiral phosphines are expensive, and their syntheses frequently require a resolution or are limited to the use of starting materials derived from enantiopure natural products. An alternative synthetic strategy might involve the enantioselective transition-metal-catalyzed addition of a PsH bond to a CdC double bond (eq 1). 2 Although hydrophosphinations have proven valuable for the

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Synthesis and Structure of Pd4(μ-PtBu2)2(μ-CS2)(PPh3)2I2, a Neutral Palladium(I) Derivative with a Hexacoordinate Carbon and a CS2 Molecule Bridging Four Palladium Centers

Journal of the American Chemical Society

The dinuclear CS 2 complex [Pd 2 (µ-P t Bu 2)(µ,η 2 :η 2-CS 2)(PPh 3) 2 ]BF 4 , (2)BF 4 , reacts ... more The dinuclear CS 2 complex [Pd 2 (µ-P t Bu 2)(µ,η 2 :η 2-CS 2)(PPh 3) 2 ]BF 4 , (2)BF 4 , reacts with Me 4 NI to yield the neutral tetranuclear Pd(I) derivative Pd 4 (µ-P t Bu 2) 2 (µ 4-CS 2)(PPh 3) 2 I 2 (4), which has been characterized by singlecrystal X-ray diffraction. Its unusual molecular structure with a formally hexacoordinate carbon atom, as well as that of (2) + with a planar tetracoordinate carbon can be explained on the basis of fragment MO considerations and EHMO model calculations. The reaction proceeds stepwise, with the relatively fast substitution of CS 2 by the iodide ion giving the intermediate complex Pd 2 (µ-P t Bu 2)(µ-I)(PPh 3) 2 (3). The latter further reacts slowly with free CS 2 to give complex 4 and free PPh 3. Complex 3 was also prepared and isolated pure by reacting [Pd 2 (µ-P t Bu 2)(PPh 3) 3 ]BF 4 with Me 4 NI.

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Asymmetric Catalytic Hydroamination of Activated Olefins in Ionic Liquids

Helvetica Chimica Acta, 2007

The addition of a series of both aliphatic and aromatic amines to electron-poor olefins was inves... more The addition of a series of both aliphatic and aromatic amines to electron-poor olefins was investigated using [Ni(Pigiphos)(THF)] 2þ as catalyst (with different counterions) in various ionic liquids based on imidazolium-and picolinium-salt derivatives. The catalysts gave rise to selectivities comparable to those obtained when the reaction was conducted in neat organic solvents (ee up to 66%), but significant higher activities, with a total turnover number (TON) of up to 300.

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Ni(ii) Complexes containing chiral tridentate phosphines as new catalysts for the hydroamination of activated olefins

Chemical Communications, 2002

Oxidative cleavage of vic-diols catalyzed by manganese (III) complexes in ionic liquids

Catalysis Communications, 2008

ABSTRACT The oxidative cleavage of vicinal diols allows the selective oxidation of diols in order... more ABSTRACT The oxidative cleavage of vicinal diols allows the selective oxidation of diols in order to obtain aldehydes or ketones. In this work we present a novel catalytic system based on MnIII(salen) complexes dissolved in ionic liquids that allows high efficiency with low environmental impact in the oxidative cleavage of ethyleneglycol, pinacol, benzopinacol and hydrobenzoin. The use of ionic liquids in this reaction shows a positive effect of the solvent in the efficiency of the MnIII catalysts (increase of the yield in ionic liquids: 10–60%).

Luca Fadini

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