Papers by Jaime Gil Rodríguez
On lung ultrasound scoring for the early evaluation of patients with COVID-19 and dyspnea
Emergencias, Aug 1, 2022
Ultrasound findings of lung ultrasonography in COVID-19: A systematic review
European Journal of Radiology, 2022
Purpose To identify the defining lung ultrasound (LUS) findings of COVID-19, and establish its as... more Purpose To identify the defining lung ultrasound (LUS) findings of COVID-19, and establish its association to the initial severity of the disease and prognostic outcomes. Method Systematic review was conducted according to the PRISMA guidelines. We queried PubMed, Embase, Web of Science, Cochrane Database and Scopus using the terms ((coronavirus) OR (covid-19) OR (sars AND cov AND 2) OR (2019-nCoV)) AND ((“lung ultrasound”) OR (LUS)), from 31st of December 2019 to 31st of January 2021. PCR-confirmed cases of SARS-CoV-2 infection, obtained from original studies with at least 10 participants 18 years old or older, were included. Risk of bias and applicability was evaluated with QUADAS-2. Results We found 1333 articles, from which 66 articles were included, with a pooled population of 4687 patients. The most examined findings were at least 3 B-lines, confluent B-lines, subpleural consolidation, pleural effusion and bilateral or unilateral distribution.B-lines, its confluent presentation and pleural abnormalities are the most frequent findings. LUS score was higher in intensive care unit (ICU) patients and emergency department (ED), and it was associated with a higher risk of developing unfavorable outcomes (death, ICU admission or need for mechanical ventilation). LUS findings and/or the LUS score had a good negative predictive value in the diagnosis of COVID-19 compared to RT-PCR. Conclusions The most frequent ultrasound findings of COVID-19 are B-lines and pleural abnormalities. High LUS score is associated with developing unfavorable outcomes. The inclusion of pleural effusion in the LUS score and the standardisation of the imaging protocol in COVID-19 LUS remains to be defined.
Tetrahedron Letters, 2004
The first total synthesis of (2S,4S)-5,5-dichloroleucine has been achieved in 11 steps from L L-p... more The first total synthesis of (2S,4S)-5,5-dichloroleucine has been achieved in 11 steps from L L-pyroglutamic acid. A key step is the dichlorination process on the hydrazone of aldehyde 13 with CuCl 2 in triethylamine.
Synlett, 2013
A short and efficient synthesis of the cyclopentane moiety of the jatrophane diterpene Pl-3 has b... more A short and efficient synthesis of the cyclopentane moiety of the jatrophane diterpene Pl-3 has been developed. The route features an enyne metathesis reaction, and a stereoselective palladium-catalyzed reductive epoxide opening as key steps.
Occurrence of iron-reducing compounds in biodelignified “palo podrido” wood samples
International Biodeterioration & Biodegradation, 2001
... Manganese ( Akhtar et al., 1997), Copper ( Watanabe et al., 1998) and Iron ( Tanaka et al., 1... more ... Manganese ( Akhtar et al., 1997), Copper ( Watanabe et al., 1998) and Iron ( Tanaka et al., 1999; Paszczynski et al., 1999; Kerem et al., 1999; Rodriguez et al., 1999; Parra and Parra; Enoki et al., 1997; Goodell et al., 1997; Hirano ... Barrasa, JM, González, AE, Martínez, AT, 1992. ...
Deep Sea Research Part II: Topical Studies in Oceanography, 2002
The patterns of variability of the size structure and functional composition of phytoplankton are... more The patterns of variability of the size structure and functional composition of phytoplankton are closely linked to physical gradients in the coastal waters of the Gerlache Strait (Antarctic Peninsula). Different stratified conditions are found at both extremes of the Strait, separated by a large, rather vertically homogeneous body of water. In the SW extreme close to Bellingshausen Sea, a cold upper layer representative of ice melting influence is dominated by microplankton (20-100 mm ESD) biomass, mainly composed of colonies or aggregates of Phaeocystis in bloom stage. In the NE extreme close to Bransfield Strait, a warm surface layer has a 10-20 mm nano planktonic community dominated by Cryptomonas and a diverse assemblage of ultraplanktonic (2-10 mm) flagellates. In this area, microplankton larger than 40 mm ESD is almost absent at the sample volume studied. Also in terms of biomass, mixed central waters are dominated by microplankton, particularly large diatoms. Our results show that diatoms and microplankton are the dominant categories under turbulent conditions, with typical flagellate blooms (Phaeocystis and Cryptomonas) under particularly stratified conditions. In terms of numerical abundance, however, ultraplanktonic flagellates usually dominate the community, giving a bell shaped size-abundance spectra in all the regions and supporting previous suggestions of flagellate dominance even under mixed-layer conditions.
Chemosphere, 2000
A cellulose bleaching euent (E 1) was degraded in batch conditions by photocatalysis using TiO 2 ... more A cellulose bleaching euent (E 1) was degraded in batch conditions by photocatalysis using TiO 2 and ZnO supported on glass Raschig rings. The euent was completely decolourised and the total phenol content was reduced by 85% after 120 min treatment with both catalysts. Partial mineralization of the organic matter was con®rmed by total organic carbon (TOC) reduction, approximately 50%. The residual organic matter shows a low acute toxicity as compared to the initial values and AOX values are strongly reduced after the photocatalytic oxidation. Molecular mass distribution showed that high molecular mass compounds were almost completely degraded.
Bioorganic & Medicinal Chemistry, 2003
Ten zoanthamine-type alkaloids from two marine zoanthids belonging to the Zoanthus genus (Zoanthu... more Ten zoanthamine-type alkaloids from two marine zoanthids belonging to the Zoanthus genus (Zoanthus nymphaeus and Zoanthus sp.) along with one semisynthetic derivative were evaluated for their antiplatelet activities on human platelet aggregation induced by several stimulating agents. 11-Hydroxyzoanthamine (11) and a synthetic derivative of norzoanthamine (16) showed strong inhibition against thrombin-, collagen-and arachidonic acid-induced aggregation, zoanthenol (15) displayed a selective inhibitory activity induced by collagen, while zoanthaminone (10) behaved as a potent aggregant agent. These evaluations allowed us to deduce several structure-activity relationships and suggest some mechanisms of action for this type of compounds.
Applied Sciences
Reverse engineering applied to architectural restoration for the reconstruction of structural sur... more Reverse engineering applied to architectural restoration for the reconstruction of structural surfaces depends on metric precision. Sometimes there are elements on these surfaces whose value is even higher than the building itself. This is the case for many churches whose ceilings have pictorial works of art. Reconstruction requires the existence of some identifiable remainder and/or a surface geometry that enables mathematical development. In our case, the vault has an irregular hemispherical geometry (without possible mathematical development), and there are no significant remains of the painting (which was destroyed by a fire). Through the 3D modelling of the irregular vault and two historic frames with a camera of unknown geometry, an inverse methodology is designed to project the original painting without metric deformations. For this, a new methodology to locate the camera positions is developed. After, a 3D virtual mathematical model of the complete image on the vault is calc...
Journal of Cultural Heritage, 2014
Restoring cultural heritage is an extremely important job due to its immeasurable value. However,... more Restoring cultural heritage is an extremely important job due to its immeasurable value. However, it also requires even greater attention in the case of a building. The actions taken on these constructions not only guarantee their preservation from the point of view of their historical value, but they also guarantee their stability as structures. The need to control historic buildings, analyzing their defects and their possible consequences, is decisive in preventing significant damage. This work demonstrates calculating the thickness of vaults in a church. It is easy to determine the interior and exterior 3D geometry of the church using scanner laser techniques. By combining both geometries, it is easy to determine the difference between the interior vaults and the roof of the church. However, the interior of both geometries is completely unknown, and it is not possible to act on their condition for structural consolidation purposes. This work shows the methods used to determine the interior sections of the vault thicknesses by referencing the internal geometry of both models with the interior of the church, using plumb line system scanning. The results obtained show accuracy better than 6 millimeters.
Digital Terrain Models (DTM) generalization results of great potential for cartographic and photo... more Digital Terrain Models (DTM) generalization results of great potential for cartographic and photogrammetric aplications, as well as for analysis processes in Geographic Information Systems (GIS) where the spread of DTM acquires greatest significance, due to the variation of scale when viewing, changes of resolution as well as the use of different cartographic databases, multimedia cartography, cartography on demand etc; for both consulting analysis as well as showing results. dependence of the filtering in the indicated order is decisive to obtain a correct evaluation of the elements and should be particularly considered when including new parameters.
Diagnostics, 2021
At the moment, several COVID-19 scoring systems have been developed. It is necessary to determine... more At the moment, several COVID-19 scoring systems have been developed. It is necessary to determine which one better predicts a poor outcome of the disease. We conducted a single-center prospective cohort study to validate four COVID-19 prognosis scores in adult patients with confirmed infection at ward. These are National Early Warning Score (NEWS) 2, Lung Ultrasound Score (LUS), COVID-19 Worsening Score (COWS), and Spanish Society of Infectious Diseases and Clinical Microbiology score (SEIMC Score). Our outcomes were the combined variable “poor outcome” (non-invasive mechanical ventilation, intubation, intensive care unit admission, and death at 28 days) and death at 28 days. Scores were analysed using univariate logistic regression models, receiver operating characteristic curves, and areas under the curve. Eighty-one patients were included, from which 21 had a poor outcome, and 9 died. We found a statistically significant correlation between poor outcome and NEWS2, LUS > 15, an...
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Papers by Jaime Gil Rodríguez