The Chinese chestnut (Castanea mollissima Blume) and other Castanea species (Castanea spp. Mill.)... more The Chinese chestnut (Castanea mollissima Blume) and other Castanea species (Castanea spp. Mill.) have been imported and circulated among growers and scientists in the United States for more than a century. Initially, importations of C. mollissima after 1914 were motivated by efforts to restore the American chestnut [Castanea dentata (Marsh.) Borkh.], with interests in timber-type characters and chestnut blight resistance. Chestnut for orchard nut production spun off from these early works. Starting in the early 20th century, open-pollinated seeds from seedlings of Chinese chestnut and other Castanea species were distributed widely to interested growers throughout much of the eastern United States to plant and evaluate. Germplasm curation and sharing increased quite robustly through grower networks over the 20th century and continues today. More than 100 cultivars have been named in the United States, although a smaller subset remains relevant for commercial production and breeding....
He received his B.S.C.E. from the University of Washington (1980), and M.S.C.E (1981) and Ph.D. (... more He received his B.S.C.E. from the University of Washington (1980), and M.S.C.E (1981) and Ph.D. (1983) degrees from Northwestern University in Chicago. He has been a faculty member at the University of Washington since 1984, working primarily in the areas of structural mechanics and computational modeling. He received a National Science Foundation Presidential Young Investigator Award in 1987, and has received numerous awards for his educational contributions at the college, university, regional, and national levels. In addition to producing various journal and conference publications, he has been involved in the development of numerous software packages for research, education, and professional applications. Several of these programs have evolved into commercial products and are used widely in education and practice.
Members of three unrelated families with the mild Becker type of muscular dystrophy were subjecte... more Members of three unrelated families with the mild Becker type of muscular dystrophy were subjected to lymphocyte capping tests and measurements of serum creatine kinase activity. Both tests correctly identified all nine affected males, but only the capping test was abnormal in seven of eight obligate carriers. The number of capped cells in carriers and affected persons with the Becker-type dystrophy was generally intermediate between those observed for individuals with the Duchenne trait and normal controls, thus potentially aiding in the differential diagnosis between the two myopathies. The lack of sensitivity of measurements of serum creatine kinase activity in identifying carriers is further complicated by the difficulty of establishing reliable reference intervals for this enzyme in 204 healthy controls. Detailed directions for the performance of the capping test are presented.
American Journal of Obstetrics and Gynecology, 2020
& < 34 weeks, and SGA (birthweight < 10% for GA, gender). Statistical analysis was by chi2, ANOVA... more & < 34 weeks, and SGA (birthweight < 10% for GA, gender). Statistical analysis was by chi2, ANOVA, and logistic regression. RESULTS: 9,038 women met inclusion criteria; 49.0% BP1, 18.6% BP2, 21.0% BP3, 10.1% BP4, and 1.4% BP5. As initial BP class increased, women were more likely to be black, diabetic, and obese pre-pregnancy (Table ). Further, as the initial BP class increased, the rate of gestational HTN AE PREE and prematurity increased, and delivery GA decreased (Table ). In regression models, these trends persisted; the most significant relationship was noted between BP class and gestational HTN AE PREE (Figure ). In a sensitivity analysis excluding 1,521 women with a prior CHTN diagnosis, effects were more pronounced, as BP class remained associated with an increased odds of gestational HTN AE PREE [BP2-OR 1.88 (95% CI 1.52-2.31), BP3-OR 2.99 (95% CI 2.47-3.62), BP4-OR 3.35 (95% CI 2.57-4.38), BP5-OR 5.15 (95% CI 2.43-10.91)]. CONCLUSION: Women with early pregnancy BP meeting revised ACA/ AHA classifications for elevated and stage 1 HTN have increased odds of hypertensive disorders of pregnancy, at a rate similar to women with early pregnancy BP !140/90.
Corporations are increasingly shaping the future of the electric grid by pursuing 100% renewable ... more Corporations are increasingly shaping the future of the electric grid by pursuing 100% renewable energy goals that seek to match their annual energy consumption with an equal volume of renewable energy. The challenge of achieving a 100% renewable electricity grid, however, is not only a question of how much renewable energy is built, but rather whether renewables can supply electricity when it is needed. One emerging approach to address this challenge is "24/7" renewable energy, which requires matching a corporation's hourly energy demand with renewable energy produced in the same region and hour. This paper explores the evolution of voluntary renewable energy procurement goals, presents a practical framework for 24/7 renewable energy procurement, and suggests policy developments that would support wider adoption of a time-matched renewables procurement approach.
Modeling and Monitoring of RTP Link on the Receiver Side
Lecture Notes in Computer Science, 2015
The paper presents a new mathematical model of a link carrying by the Real Time Transport Protoco... more The paper presents a new mathematical model of a link carrying by the Real Time Transport Protocol. The model attempts to meet the key features of the real link functioning like the frame delays, losses, bursting reception etc. The proposed approach is based on the Hidden Markov concept. The unobservable state is assumed to be a finite-dimensional Markov process. The observation is a non-Markovian multivariate point process that indicates heterogenous frames reception. The paper also contains the formulation and solution to the filtering problem of the hidden link state given the observable multivariate point process. Proposed link model validity and filtering algorithm performance are illustrated by processing of captured real video streams delivered via 3G mobile network.
American Journal of Obstetrics and Gynecology, 2016
OBJECTIVE: Maternal pro-inflammatory phenotype in pregnancy may be associated with greater preter... more OBJECTIVE: Maternal pro-inflammatory phenotype in pregnancy may be associated with greater preterm birth risk. Poor romantic partner relationships have been linked to pro-inflammatory phenotypes in non-pregnant samples. Little is known on how romantic partner relationship quality shapes inflammation over pregnancy. Our objective was to determine if romantic partner relationship quality was associated with change in maternal pro-inflammatory phenotype during pregnancy. STUDY DESIGN: 74 pregnant women were assessed at Trimester 2 (Tri2) and 3 (Tri3). Self-reported positive and negative romantic partner relationship quality was obtained with validated tools at Tri2. Tri2 and Tri3 maternal serum interleukin-10 (IL10) and IL6 were measured using electrochemiluminescence. Maternal inflammation regulation was modeled by calculating pro-and anti-inflammatory cytokine balance, specifically IL6:IL10 ratio. Tri2 and Tri3 IL10, IL6 and IL6:IL10 changes were modeled. RESULTS: IL10 was constant, IL6 and IL6:IL10 increased between Tri2 and Tri3, suggesting an emerging pro-inflammatory phenotype. Positive and negative relationship quality interacted to predict IL6:IL10 change, b(SE) ¼ .23(.09), p ¼ .02: Women with high positive quality partner relationships had stable, low IL6:IL10. Women with low positive and low negative quality (indifferent) partner relationships had greatest increases in IL6:IL10, independent of demographics, gestational age, weeks between assessment, parity, pre-pregnancy body mass index, maternal stress, distress and mood. CONCLUSION: In sum, romantic partner relationship quality was associated with maternal serum pro-inflammatory phenotype change between Tri2 and Tri3. High positive relationships were associated with maintained anti-inflammatory phenotype into Tri3. Indifferent relationships (low positive and low negative quality) were associated with increasing pro-inflammatory phenotype. Future work should investigate association with adverse pregnancy outcomes.
We model the pursuit problem as a set of distributed agents communicating over a network subject ... more We model the pursuit problem as a set of distributed agents communicating over a network subject to latency. Latency has serious deleterious effects on solving the pursuit problem. In this paper, we present a simple, yet effective way of dealing with latency that yields very good performance. Our method disperses predators within a region in which the prey may move that accounts for network latency.
Viral infection is a common, life-threatening complication after allogeneic bone marrow transplan... more Viral infection is a common, life-threatening complication after allogeneic bone marrow transplantation (BMT), particularly in the presence of graft-versus-host disease (GVHD). Using cytomegalovirus (CMV) as the prototypic pathogen, we have delineated the mechanisms responsible for the inability to mount protective anti-viral responses in this setting. While CMV infection was self-limiting after syngeneic BMT, in the presence of GVHD after allogeneic BMT, CMV induced a striking cytopathy resulting in universal mortality in conjunction with a fulminant necrotizing hepatitis. Critically, GVHD induced a profound DC defect that led to a failure in the generation of CMV-specific CD8(+) T cell responses. This was accompanied by a defect in anti-viral CD8(+) T cells. In combination, these defects dramatically limited anti-viral T cell responses. The transfer of virus-specific cells circumvented the DC defects and provided protective immunity, despite concurrent GVHD. These data demonstrate...
We consider an uplink power control problem where each mobile wishes to maximize its throughput (... more We consider an uplink power control problem where each mobile wishes to maximize its throughput (which depends on the transmission powers of all mobiles) but has a constraint on the average power consumption. A finite number of power levels are available to each mobile. The decision of a mobile to select a particular power level may depend on its channel state. We consider two frameworks concerning the state information of the channels of other mobiles: (i) the case of full state information and (ii) the case of local state information. In each of the two frameworks, we consider both cooperative as well as non-cooperative power control. We manage to characterize the structure of equilibria policies and, more generally, of bestresponse policies in the non-cooperative case. We present an algorithm to compute equilibria policies in the case of two noncooperative players. Finally, we study the case where a malicious mobile, which also has average power constraints, tries to jam the communication of the other mobile. Our results are illustrated and validated through various numerical examples.
Background: It is hypothesised that complex interactions between genetic and environmental factor... more Background: It is hypothesised that complex interactions between genetic and environmental factors give rise to allergy and asthma in childhood. The Canadian Healthy Infant Longitudinal Development (CHILD) study was designed to explore these factors. Methods: CHILD is a longitudinal, general population birth cohort study following infants from mid-pregnancy to age 5 years. Over this time period, biological samples, questionnaires, clinical measures and environmental data are collected. Results: A total of 3624 families have been recruited, and many thousands of samples and questionnaires have been collected, annotated, and archived. This report outlines the rationale and methodology for collecting and storing diverse biological samples from parents and children in this study, and the mechanisms for their release for analyses. The CHILD sample and data repository is a tremendous current and future resource and will provide a wealth of information not only informing studies of asthma and allergy, but also potentially in many other aspects of health relevant for Canadian infants and children.
Analytical methods were developed for a directed enzyme evolution research programme, which pursu... more Analytical methods were developed for a directed enzyme evolution research programme, which pursued high performance enzymes to produce high quality l-ribose using large scale biocatalytic reaction. A high throughput HPLC method with evaporative light-scattering detection was developed to test ribose and ribitol in the enzymatic reaction, a -cyclobond 2000 analytical column separated ribose and ribitol in 2.3 min, a C 18 guard column was used as an on-line filter to clean up the enzyme sample matrix and a short gradient was applied to wash the column, the enzymatic reaction solution can be directly injected after quenching. Total run time of each sample was approx. 4 min which provided capability of screening 4 × 96-well plates/day/instrument. Meanwhile, a capillary electrophoresis method was developed for the separation of ribose enantiomers, while 7-aminonaphthalene-1,3-disulfonic acid was used as derivatisation reagent and 25 mM tetraborate with 5 mM -cyclodextrin was used as electrolyte. 0.35%of d-ribose in l-ribose can be detected which can be translated into 99.3% ee of l-ribose. Derivatisation reagent and sample matrix did not interfere with the measurement.
Uploads
Papers by Gregory Miller