Papers by Francisco Pérez-jiménez
British Journal of Nutrition, 2008
Traditional cardiovascular risk factors are associated with endothelial dysfunction. The vascular... more Traditional cardiovascular risk factors are associated with endothelial dysfunction. The vascular endothelium plays a key role in local vascular tone regulation and can be modulated by dietary fat. We propose to determine the chronic effect of three diets with different fat compositions on postprandial endothelial function and inflammatory biomarkers. Twenty healthy men followed three 4-week diets in a randomised cross-over design: a Western diet, rich in saturated fat (22 % SFA, 12 % MUFA and 0·4 % α-linolenic acid (ALA), all fractions are % of energy); a Mediterranean diet, rich in MUFA ( < 10 % SFA, 24 % MUFA and 0·4 % ALA); a low-fat diet enriched in ALA ( < 10 % SFA, 12 % MUFA and 2 % ALA). At the end of each dietary period all subjects underwent a postprandial study. Plasma concentrations of lipid parameters, soluble intercellular cell-adhesion molecule-1, soluble vascular cell-adhesion molecule-1 (sVCAM-1), nitrates and nitrites (NOx) and endothelial function studied by...
Microbiota sequences data
This file contains the microbiota sequences data from "Intestinal microbiota is influenced b... more This file contains the microbiota sequences data from "Intestinal microbiota is influenced by gender and body mass index" study
Phenolic Compounds of Olive Oil in a Given Concentration and Their Uses
Compuestos fenolicos del aceite de oliva en una determinada concentracion y sus usos.#Uso de comp... more Compuestos fenolicos del aceite de oliva en una determinada concentracion y sus usos.#Uso de compuestos fenolicos del aceite de oliva en una determinada concentracion, para la elaboracion de un medicamento o composicion farmaceutica o alimentaria, para la prevencion o el tratamiento de la arteriosclerosis en humanos.
Treatment of mild-to-moderate hypertriglyceridemia
Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis, 2021
The atherogenic role of triglycerides (TG) as an independent cardiovascular risk factor has been ... more The atherogenic role of triglycerides (TG) as an independent cardiovascular risk factor has been discussed for many years, largely because hypertriglyceridaemia (HTG) is a complex metabolic entity of multiple aetiology involving processes of diverse nature. In this chapter, a discussion will be presented on the current recommendations for the management of mild-moderate hypertriglyceridaemia (150-880mg/dL). The aim of the interventions used is to decrease the LDL-cholesterol (c-LDL) and control the HTG. This entails reducing apoprotein B (ApoB) levels, the number of remaining TG-rich lipoproteins (LRP), non-HDL-cholesterol (c-non-HDL), and increasing HDL-cholesterol (c-HDL). The management strategy includes healthy lifestyle recommendations, and subsequent use of lipid-lowering drugs, including statins, fibrates, n-3 fatty acids and PCSK9 inhibitors.
Nutrients, 2021
There is growing interest in the potential health-related effects of moderate alcohol consumption... more There is growing interest in the potential health-related effects of moderate alcohol consumption and, specifically, of beer. This review provides an assessment of beer-associated effects on cardiovascular and metabolic risk factors to identify a consumption level that can be considered “moderate”. We identified all prospective clinical studies and systematic reviews that evaluated the health effects of beer published between January 2007 and April 2020. Five of six selected studies found a protective effect of moderate alcohol drinking on cardiovascular disease (beer up to 385 g/week) vs. abstainers or occasional drinkers. Four out of five papers showed an association between moderate alcohol consumption (beer intake of 84 g alcohol/week) and decreased mortality risk. We concluded that moderate beer consumption of up to 16 g alcohol/day (1 drink/day) for women and 28 g/day (1–2 drinks/day) for men is associated with decreased incidence of cardiovascular disease and overall mortalit...
Clínica e Investigación en Arteriosclerosis (English Edition), 2019
Clínica e Investigación en Arteriosclerosis, 2018
Tabla 1 Contenido medio de ácidos grasos de los aceites culinarios de uso habitual (gramos por 10... more Tabla 1 Contenido medio de ácidos grasos de los aceites culinarios de uso habitual (gramos por 100 g)
Current pharmaceutical design, Jan 17, 2017
Cardiovascular disease (CVD) continues to be the major cause of death in the developed countries.... more Cardiovascular disease (CVD) continues to be the major cause of death in the developed countries. Moreover, the cardiovascular risk factors leading towards the development of CVD, mainly type 2 diabetes and obesity, are on the rise. The current preventive and therapeutic management, centred on the control of traditional risk factors, is clearly not enough to stop this pandemic. Therefore, the search for new biomarkers in CVD is a priority in most clinical research programs. Currently, interest in gut microbiota has peaked due to its association with cardiovascular and non-cardiovascular diseases. The present review considers the current situation regarding the influence of gut microbiota on CVD and particularly, its influence on the main traditional risk factors that lead to CVD, such as lipids, diabetes, hypertension and obesity.
Clinical Nutrition, 2016
The cholesteryl ester transfer protein (CETP) gene has been implicated in high-density lipoprotei... more The cholesteryl ester transfer protein (CETP) gene has been implicated in high-density lipoprotein (HDL-C) metabolism. However, little is known about the impact of this gene on metabolic syndrome (MetS) patients and its interaction with diet. Here, we evaluate whether the consumption of a Mediterranean diet, compared with a Low-fat diet, interacts with the rs3764261 SNP at the CETP locus to modify lipid metabolism in MetS patients. Plasma lipid concentrations and rs3764261 genotypes were determined in 424 MetS subjects participating in the CORDIOPREV clinical trial (NCT00924937). Gene-diet interactions were analyzed after a year of dietary intervention (Mediterranean diet (35% fat, 22% MUFA) vs Low-fat diet (28% fat, 12% MUFA)). We found significant geneediet interactions between rs3764261 SNP and the dietary pattern for HDL-C (P ¼ 0.006) and triglyceride concentrations (P ¼ 0.040). Specifically, after 12 months of Mediterranean diet intervention, subjects who were carriers of the minor T allele (TT þ TG) displayed higher plasma HDL-C concentrations (P ¼ 0.021) and lower triglycerides (P ¼ 0.020) compared with those who were homozygous for the major allele (GG). In contrast, in the Low-fat intervention group, no significant differences were found between CETP genotypes after 12 months of dietary treatment. Our data support the notion that the consumption of a Mediterranean diet may play a contributing role in triggering lipid metabolism by interacting with the rs3764261 SNP at CETP gene locus in MetS patients. Due to the complex nature of geneeenvironment interactions, dietary adjustment in MetS patients may require a personalized approach.
Consejos para ayudar a controlar el colesterol con una alimentación saludable
Clínica e Investigación en Arteriosclerosis, 2006
... Debe evitarse el coco (rico en grasa saturada) así como cualquiera de estos productos si está... more ... Debe evitarse el coco (rico en grasa saturada) así como cualquiera de estos productos si están coci-nados con aceites no recomendables o si en la ela-boración del plato se incluyen productos ricos en grasa saturada tipo chorizo, beicon, etc. Page 6. ...
Ambiente mediterráneo y protección sobre el riesgo cardiovascular del paciente con diabetes de tipo 1
Medicina Clínica, 2009
La enfermedad cardiovascular es la principal causa de morbilidad en los paı́ses industrializados ... more La enfermedad cardiovascular es la principal causa de morbilidad en los paı́ses industrializados y un problema creciente en todo el mundo. Desde hace años, y con objeto de desarrollar estrategias preventivas eficaces a partir de los estudios observacionales, se han generado herramientas que ayudan al médico clı́nico a definir el riesgo individual de sus pacientes. Estos procedimientos son guı́as para el cálculo del riesgo global del individuo y, entre éstos, los más utilizados son la guı́a generada por el Panel de Expertos del Programa Nacional de Colesterol de EE. UU. y la Guı́a elaborada por distintas sociedades cientı́ficas europeas, recientemente actualizada. Pero tanto una como otra tienen importantes limitaciones, en especial porque son incapaces de incorporar la especificidad individual a la hora de predecir el riesgo de presentar un episodio cardiovascular. Por esto, aunque son útiles desde la perspectiva de la orientación general, el médico sigue sin tener una herramienta segura para transmitir al paciente una predicción suficientemente sólida que permita establecer un plan preventivo sobre bases suficientemente indiscutibles. Esto es especialmente llamativo en los pacientes incluidos en lo que se denomina )el grupo de riesgo intermedio*, en los que el riesgo que proporcionan las guı́as no permite diferenciar si el paciente debe manejarse como de bajo o de alto riesgo, situación que afecta nada menos que a un 40% de la población adulta americana. De ahı́ los esfuerzos por buscar otras vı́as, alternativas o complementarias, a esta evaluación tradicional y ası́ poder definir con mejor precisión el riesgo real individual que permita hacer abordajes más personalizados. Actualmente se está explorando esta idea con 2 aproximaciones: la búsqueda de biomarcadores solubles y el empleo de los denominados objetivos (criterio de valoración) subrogados. Los primeros aprovechan ciertos componentes, que pueden medirse y evaluarse objetivamente con pruebas de laboratorio y que son el reflejo de fenómenos biológicos normales, de procesos patogénicos o de respuestas de nuestro organismo a intervenciones terapéuticas. Los objetivos subrogados son, sin embargo, marcadores que pretenden sustituir a las manifestaciones clı́nicas de la
Cardiovascular Benefits of Olive Oil: Beyond Effects of Fat Content
Health Benefits and Functional Foods, 2013
Efecto de los compuestos fenólicos del aceite de oliva virgen sobre la resistencia de las lipoproteínas de baja densidad a la oxidación
Medicina Clínica, 2003
Fundamento y objetivo: Varios estudios epidemiológicos y experimentales han relacionado la ingest... more Fundamento y objetivo: Varios estudios epidemiológicos y experimentales han relacionado la ingestión de antioxidantes, abundantes en la alimentación mediterránea, con una baja incidencia de enfermedad cardiovascular. Uno de los posibles mecanismos de dicha acción es la ...
Grado de respuesta del colesterol LDL a la alimentación en varones con hipercolesterolemia según sus valores basales
Medicina Clínica, 2002
... Elsevier 8. Pérez-Martínez P, Gómez P, Paz E, Marín C, Gavilán Moral E, López-Miranda J, et .... more ... Elsevier 8. Pérez-Martínez P, Gómez P, Paz E, Marín C, Gavilán Moral E, López-Miranda J, et ... de la Puebla, Rafael Angel Fernández a ; Carmona, José a ; Fuentes, Francisco a ; Marín, Carmen a ; Gómez, Purificación a ; López-Miranda, José a ; Pérez-Jiménez, Francisco a. ...
The American journal of clinical nutrition, 2007
Oxidative stress associated with postprandial lipemia contributes to endothelial dysfunction, whi... more Oxidative stress associated with postprandial lipemia contributes to endothelial dysfunction, which shifts hemostasis to a more thrombogenic state. We investigated whether a high concentration of phenols in olive oil can partly reverse this phenomenon. Twenty-one hypercholesterolemic volunteers received 2 breakfasts rich in olive oils with different phenolic contents (80 or 400 ppm) according to a randomized, sequential crossover design. Plasma concentrations of lipid fractions, factor VII antigen (FVIIag), activated factor VII (FVIIa), and plasminogen activator inhibitor-1 (PAI-1) activity were measured at baseline and postprandially. Concentrations of FVIIa increased less (P = 0.018) and plasma PAI-1 activity decreased more (P = 0.021) 2 h after the high-phenol meal than after the low-phenol meal. FVIIa concentrations 120 min after intake of the olive oil with a high phenol content correlated positively with fasting plasma triacylglycerols (P = 0.001), area under the curve (AUC) o...
The Journal of nutrition, 2008
Adiponectin (adipoQ) gene variants have been associated with type 2 diabetes mellitus and insulin... more Adiponectin (adipoQ) gene variants have been associated with type 2 diabetes mellitus and insulin resistance. Our aim was to examine whether the presence of several polymorphisms at the adipoQ gene locus (-11391 G > A, -11377 C…
[Effect of two hypocaloric diets and their combination with physical exercise on basal metabolic rate and body composition]
Nutrición hospitalaria, 2014
Metabolic syndrome (MetS) is diagnosed by the detection of at least three criteria (hypertriglyce... more Metabolic syndrome (MetS) is diagnosed by the detection of at least three criteria (hypertriglyceridemia, low HDL-C, hypertension, obesity and altered fasting glucose). Visceral fat excess would be the starting point for its development. Scientific evidence supports hypocaloric diets -mediterranean or low fat diet and rich in complex carbohydrates diet included- as the best treatment to reduce fat mass (FM), maximizing its impact by combining them with physical exercise (PE). However, the effects of these treatments on basal metabolic rate (BMR) of patients with MetS, are unknown. To study the effect of the hypocaloric diet - mediterranean or low fat diet- with or without PE on the BMR and body composition (BC) of adults with MetS. 36 volunteers, MetS, both sexes, > 50 years, meeting the inclusion criteria. They were randomly assigned to a group of intervention (3 months) of hypocaloric diet: mediterranean diet (MED), low fat and rich in complex carbohydrates diet (CHO) and both ...
Atherosclerosis Supplements, 2010
The Journal of nutrition, 2004
LDL particle size is dependent on both genetic factors and environmental factors such as dietary ... more LDL particle size is dependent on both genetic factors and environmental factors such as dietary fat composition. The apolipoprotein E (apoE) genotype is a major genetic determinant of LDL size. Thus, the aim of this work was to study whether the apoE genotype interacts with the quantity and quality of dietary fat, modifying LDL size in young healthy subjects. Healthy subjects (n = 84; 66 apoE 3/3, 8 apoE 4/3, 10 apoE 3/2) were subjected to 3 dietary periods, each lasting 4 wk. The first was an SFA-enriched diet (38% fat, 20% SFA), which was followed by a carbohydrate (CHO)-rich diet (30% fat, < 10% SFA, 55% carbohydrate) or a monounsaturated fatty acid (MUFA) olive oil-rich diet (38% fat, 22% MUFA) following a randomized crossover design. At the end of each diet period, LDL particle size and plasma levels of total cholesterol, LDL cholesterol (LDL-C), HDL-C, apoB, apoA-I, and triacylglycerols were determined. LDL particle size was significantly higher (P < 0.04) in subjects w...
La dieta mediterránea mejora la resistencia a la oxidación de las lipoproteínas de baja densidad (LDL)
Medicina Clínica, 2000
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Papers by Francisco Pérez-jiménez