The aim, herein, was to prove that the analysis of the stress concentration phenomenon with simul... more The aim, herein, was to prove that the analysis of the stress concentration phenomenon with simulation methods provides results that fit those obtained experimentally, thus, corroborating that simulation is a powerful tool that minimizes costs and time in the construction of stress concentrator curves. The experimental curves of stress concentration factors available in the scientific literature can be recreated through simulations, achieving results with low errors. Due to this, geometries were selected with different shape ratios for study; these were developed in the DesingModeler® module of the ANSYS Workbench®, then meshed in the Mechanical® module, and three types of load were applied in their borders: axial force, flexing moment, and torsional moment; these were configured in the StaticStructural® module. After obtaining the maximum force and having calculated the nominal force, these were related by calculating the concentration factor to plot it against the geometric parameter modified during the virtual experimentation. In the end, these were compared with the experimental curves consulted. With the results obtained, it was concluded that it is possible to construct curves of stress concentration factor through simulations, with the same reliability as with conventional experimental methods, but at a lower cost.
Raigame: revista de arte, cultura e tradicións populares, 2011
FELIPE-SENÉN LÓPEZ GÓMEZ Carballiñés, estudia Historia da Arte na universidade Compostelán, colab... more FELIPE-SENÉN LÓPEZ GÓMEZ Carballiñés, estudia Historia da Arte na universidade Compostelán, colaborador con Manuel Chamoso Lamas ate o seu pasamento. Dende 1975 ate 1996 Director-Conservador do Museo Arqueolóxico de A Coruña. Na actualidade Museólogo e Técnico de Xestión Cultural da Deputación da Coruña. Membro do Instituto de Estudos Galegos "Padre Sarmiento" (1977). Numerario da Real Academia Galega de Belas Artes (1987), numerario do "Instituto Xosé Cornide de Estudos Coruñeses" (1988). Autor de innumerables traballos sobre temas de etnoarqueoloxía, simbolismo e museoloxía.
There is a growing evidence describing a decline in adaptive homeostasis in agingrelated diseases... more There is a growing evidence describing a decline in adaptive homeostasis in agingrelated diseases affecting the central nervous system (CNS), many of which are characterized by the appearance of non-native protein aggregates. One signaling pathway that allows cell adaptation is the integrated stress response (ISR), which senses stress stimuli through four kinases. ISR activation promotes translational arrest through the phosphorylation of the eukaryotic translation initiation factor 2 alpha (eIF2α) and the induction of a gene expression program to restore cellular homeostasis. However, depending on the stimulus, ISR can also induce cell death. One of the ISR sensors is the double-stranded RNA-dependent protein kinase [protein kinase R (PKR)], initially described as a viral infection sensor, and now a growing evidence supports a role for PKR on CNS physiology. PKR has been largely involved in the Alzheimer's disease (AD) pathological process. Here, we reviewed the antecedents supporting the role of PKR on the efficiency of synaptic transmission and cognition. Then, we review PKR's contribution to AD and discuss the possible participation of PKR as a player in the neurodegenerative process involved in aging-related pathologies affecting the CNS.
EPRA international journal of multidisciplinary research, Dec 20, 2022
Introduction: fractures of the fifth metatarsal have various forms of treatment, depending on the... more Introduction: fractures of the fifth metatarsal have various forms of treatment, depending on the type of injury and the person who suffered it. They have great importance and frequency in athletes. They usually occur due to different trauma mechanisms. They were first described in 1902. They are the most prevalent metatarsal fractures and need to be recognized and treated in a timely and appropriate manner. Objective: to detail the current information related to the fifth metatarsal fracture, classification, description, treatment, recovery time as well as the different surgical techniques. Methodology: a total of 29 articles were analyzed in this review, including review and original articles, as well as clinical cases, of which 19 bibliographies were used because the other 10 articles were not relevant for this study. The sources of information were PubMed, Google Scholar and Cochrane; the terms used to search for information in Spanish, Portuguese and English were: fractura de pie, 5th metatarsal fracture, Jones fracture. Fracture of the fifth metatarsal, fratura do quinto metatarso. Results: the anatomical division system of Lawrence and Bottle is still used. CT and MRI could be considered in the case of delayed healing, stress fracture with normal radiographs or in nonunion. Surgical options include intramedullary screw fixation, bone grafting procedures or a combination of both. Surgical treatment of fractures of the base of the fifth metatarsal in professional athletes offers good clinical results. Conclusions: Regarding the current information related to the fracture of the fifth metatarsal, we note the importance of classification, clinical and social history of the patient, for the appropriate choice of treatment, both conservative and surgical. As for the recovery time in conservative treatment varies depending on the affected area. In delayed union or nonunion, surgical intervention should be performed.
This paper presents an investigation on how to model a backfill masonry arch bridge using the dis... more This paper presents an investigation on how to model a backfill masonry arch bridge using the discrete element method (DEM). The PFC2D software is used for this purpose. A certain backfill masonry arch bridge is modelled, with different types of fill, mortar and voussoir materials. A biaxial test has been programmed using 'FISH' code to obtain the micro-parameters used in the model so that they match the macro-parameters obtained from a real biaxial test. The arch is loaded until its collapse in three different load cases. Further discussion on the influence of the backfill parameters is presented as well as a sensitivity analysis for the arch bridge.
Perseverance's Mars Environmental Dynamics Analyzer (MEDA) is collecting data at Jezero Crate... more Perseverance's Mars Environmental Dynamics Analyzer (MEDA) is collecting data at Jezero Crater, characterizing the physical processes in the lowest layer of the atmosphere as no previous instrument did before. Here we show that temperature measurements at four heights capture the response of the atmospheric surface layer to multiple phenomena. We observe the transition from a stable nighttime thermal inversion to a diurnal, highly turbulent convective regime, with large vertical thermal gradients, and where local surface properties (such as Thermal Inertia) play an essential role. Recording multiple daily optical depths yielded higher aerosol concentrations in the morning than in the afternoon. Measured wind patterns are mainly driven by local topography, with a small contribution from regional winds. Daily and seasonal variability of relative humidity shows a complex hydrologic cycle. These observations raise new puzzles in which changes in surface albedo and thermal inertia ma...
The objective of the present study is to check that curves of factor concentration available in t... more The objective of the present study is to check that curves of factor concentration available in the literature, experimental efforts, can be performed by means of simulations making a significant adjustment. For this reason, we selected two geometries for the study: shaft with thru hole and shaft with sudden change in cross-sectional area. For both geometries it was obtained the maximum effort and calculated nominal effort as the relations between the applied force and the minimum area perpendicular to the force, in order to be able, from them, assess the concentration of effort factor, plot and compare it to the pilot. Finally, with the obtained results we can conclude that it is possible to build curves of factor concentration of effort by means of simulations, with the same confidence that have conventional experimental methods, but at a lower cost.
Revista de la Facultad de Medicina Veterinaria y de Zootecnia, 2020
Gastric ulcers are defined as the loss of continuity of the gastric mucosal. They are mainly caus... more Gastric ulcers are defined as the loss of continuity of the gastric mucosal. They are mainly caused by an imbalance between harmful and protective factors of the stomach. It generally manifests itself with signs such as weight loss, colic, bruxism and inappetence, which can lead to low performance and economic losses. The objective of the present study was to determine the prevalence and risk factors for the presentation of SUGE in CCC of the Valle del Aburra. Gastroscopy was made to 100 animals from different stables, between two and 25 years of age; each stomach characterized, macro and microscopically. Lesions are evaluate depending on the degree of injury to the “Equine Gastric Council”. Microscopic lesions classification was based on an adaptation by patterns most commonly used description of injuries such as: the Sidney System and the equine gastritis grading system (EGGS) (Martineau et al 2009). For the analysis of the results, variables such as exercise intensity, accommodat...
Se evaluo la resistencia de un aislado bacteriano compatible con Pseudomona sp. frente al insecti... more Se evaluo la resistencia de un aislado bacteriano compatible con Pseudomona sp. frente al insecticida Lorsban 4EC (ingrediente activo Chlorpyrifos) a escala de laboratorio. El aislado bacteriano se obtuvo a partir de un suelo del Oriente Antioqueno sometido a la aplicacion del insecticida para el cultivo de pastos.Al suelo se le analizaron los principales factores que afectan la movilidad y adsorcion del insecticida en el, se obtuvieron como resultados un porcentaje alto de materia organica, elementos mayores y menores asi como media a alta capacidad de intercambio cationico, lo que facilita la adsorcion del plaguicida en su fraccion coloidal de la micela organica e inorganica. La textura franco arenosa del suelo genera buena aireacion, que favorece los procesos de volatilizacion y degradacion del plaguicida. El aislado bacteriano se expuso a diferentes concentraciones del insecticida (480 ppm, 4.800 ppm, 24.000 ppm y 48.000 ppm), evaluando de esta manera el efecto del agente sobre ...
The Mars 2020 Perseverance rover landing site is located within Jezero crater, a ∼ 50 km diameter... more The Mars 2020 Perseverance rover landing site is located within Jezero crater, a ∼ 50 km diameter impact crater interpreted to be a Noachian-aged lake basin inside the western edge of the Isidis impact structure. Jezero hosts remnants of a fluvial delta, inlet and outlet valleys, and infill deposits containing diverse carbonate, mafic, and hydrated minerals. Prior to the launch of the Mars 2020 mission, members of the Science Team collaborated to produce a photogeologic map of the Perseverance landing site in Jezero crater. Mapping was performed at a 1:5000 digital map scale using a 25 cm/pixel High Resolution Imaging Science Experiment (HiRISE) orthoimage mosaic base map and a 1 m/pixel HiRISE stereo digital terrain model. Mapped bedrock and surficial units were distinguished by differences in relative brightness, tone, topography, surface texture, and apparent roughness. Mapped bedrock units are generally consistent with those identified in previously published mapping efforts, but this study's map includes the distribution of surficial deposits and sub-units of the Jezero delta at a higher level of detail than previous studies. This study considers four possible unit correlations to explain the relative age relationships of major units within the map area. Unit correlations include previously published interpretations as well as those that consider more complex interfingering relationships and alternative relative age relationships. The photogeologic map presented here is the foundation for scientific hypothesis development and strategic planning for Perseverance's exploration of Jezero crater.
BackgroundExtreme terrestrial, analogue environments are widely used models to study the limits o... more BackgroundExtreme terrestrial, analogue environments are widely used models to study the limits of life and to infer habitability of extraterrestrial settings. In contrast to Earth’s ecosystems, potential extraterrestrial biotopes are usually characterized by a lack of oxygen.MethodsIn the MASE project (Mars Analogues for Space Exploration), we selected representative anoxic analogue environments (permafrost, salt-mine, acidic lake and river, sulfur springs) for the comprehensive analysis of their microbial communities. We assessed the microbiome profile of intact cells by propidium monoazide-based amplicon and shotgun metagenome sequencing, supplemented with an extensive cultivation effort.ResultsThe information retrieved from microbiome analyses on the intact microbial community thriving in the MASE sites, together with the isolation of 31 model microorganisms and successful binning of 15 high-quality genomes allowed us to observe principle pathways, which pinpoint specific microb...
ABSTRACTTargeting MAIT cells holds promise for the treatment of different diseases and infections... more ABSTRACTTargeting MAIT cells holds promise for the treatment of different diseases and infections. We previously showed that treatment of Mycobacterium tuberculosis infected mice with 5-OP-RU, a major antigen for MAIT cells, expands MAIT cells and enhances bacterial control. Here we treated M. tuberculosis infected rhesus macaques with 5-OP-RU intratracheally but found no clinical or microbiological benefit in M. tuberculosis infected macaques. In fact, after 5-OP-RU treatment MAIT cells did not expand, but rather upregulated PD-1 and lost the ability to produce multiple cytokines, a phenotype resembling T cell exhaustion. Furthermore, we show that vaccination of uninfected macaques with 5-OP-RU+CpG instillation into the lungs also drives MAIT cell dysfunction, and PD-1 blockade during vaccination partly prevents the loss of MAIT cell function without facilitating their expansion. Thus, in rhesus macaques MAIT cells are prone to the loss of effector functions rather than expansion a...
Throughout the last decade, a whole new generation of powered transtibial prostheses and exoskele... more Throughout the last decade, a whole new generation of powered transtibial prostheses and exoskeletons has been developed. However, these technologies are limited by a gait phase detection which controls the wearable device as a function of the activities of the wearer. Consequently, gait phase detection is considered to be of great importance, as achieving high detection accuracy will produce a more precise, stable, and safe rehabilitation device. In this paper, we propose a novel gait percent detection algorithm that can predict a full gait cycle discretised within a 1% interval. We called this algorithm an exponentially delayed fully connected neural network (ED-FNN). A dataset was obtained from seven healthy subjects that performed daily walking activities on the flat ground and a 15-degree slope. The signals were taken from only one inertial measurement unit (IMU) attached to the lower shank. The dataset was divided into training and validation datasets for every subject, and th...
Universidad Colegio Mayor Nuestra Senora Del Rosario Universidad Del Rosario Edocur Repositorio Institucional Disponible En Http Repository Urosario Edu Co, Feb 1, 2012
We explore the ground-temperature data from REMS on MSL to characterize their diurnal cycle and p... more We explore the ground-temperature data from REMS on MSL to characterize their diurnal cycle and possible balances with solar radiation and air temperature.
REMS-P, the pressure measurement subsystem of the Mars Science Laboratory (MSL) Rover Environment... more REMS-P, the pressure measurement subsystem of the Mars Science Laboratory (MSL) Rover Environmental Measurement Station (REMS), is performing accurate observations of the Martian atmospheric surface pressure. It has demonstrated high data quality and good temporal coverage, carrying out the first in situ pressure observations in the Martian equatorial regions. We describe the REMS-P initial results by MSL mission sol 100 including the instrument performance and data quality and illustrate some initial interpretations of the observed features. The observations show both expected and new phenomena at various spatial and temporal scales, e.g., the gradually increasing pressure due to the advancing Martian season signals from the diurnal tides as well as various local atmospheric phenomena and thermal vortices. Among the unexpected new phenomena discovered in the pressure data are a small regular pressure drop at every sol and pressure oscillations occurring in the early evening. We look forward to continued high-quality observations by REMS-P, extending the data set to reveal characteristics of seasonal variations and improved insights into regional and local phenomena.
We provide a preliminary interpretation of the Rover Environmental Monitoring Station (REMS) pres... more We provide a preliminary interpretation of the Rover Environmental Monitoring Station (REMS) pressure data from the first 100 Martian solar days (sols) of the Mars Science Laboratory mission. The pressure sensor is performing well and has revealed the existence of phenomena undetected by previous missions that include possible gravity waves excited by evening downslope flows, relatively dust‐free convective vortices analogous in structure to dust devils, and signatures indicative of the circulation induced by Gale Crater and its central mound. Other more familiar phenomena are also present including the thermal tides, generated by daily insolation variations, and the CO2 cycle, driven by the condensation and sublimation of CO2 in the polar regions. The amplitude of the thermal tides is several times larger than those seen by other landers primarily because Curiosity is located where eastward and westward tidal modes constructively interfere and also because the crater circulation am...
To analyze immediate and long-term results of balloon dilation for aortic coarctation in a three-... more To analyze immediate and long-term results of balloon dilation for aortic coarctation in a three-center experience in Mexico, and to determine factors associated with increased risk. Results demonstrated that the procedure is effective and safe, however its use in some groups is still controversial, specially in neonates and infants. In a ten-year period, 333 patients with aortic coarctation on underwent balloon dilation with an immediate success rate of 93.7% and a major complication incidence of 1.8%. Of the total cohort, 272 patients were followed for a period of 24.3 +/- 20 months. Demographic and procedural data were analyzed to determine factors related to a poor outcome or to sustained high blood pressure. Cox regression analysis found age (risk ratio 3.42 p = 0.0001), isthmic hypoplasia (risk ratio 4.64, p < 0.0001), and post-dilation gradient (risk ratio 2.19, p = 0.0113) as independent risk factors for a follow-up event, mainly restenosis. Age at dilation was the only i...
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