On a two-dimensional quasicrystal, a Penrose tiling, we simulate for the first time a game of lif... more On a two-dimensional quasicrystal, a Penrose tiling, we simulate for the first time a game of life dynamics governed by non-local rules. Quasicrystals have inherently non-local order since any local patch, the emperor, forces the existence of a large number of tiles at all distances, the empires. Considering the emperor and its local patch as a quasiparticle, in this case a glider, its empire represents its field and the interaction between quasiparticles can be modeled as the interaction between their empires. Following a set of rules, we model the walk of life in different setups and we present examples of self-interaction and two-particle interactions in several scenarios. This dynamic is influenced by both higher dimensional representations and local choice of hinge variables. We discuss our results in the broader context of particle physics and quantum field theory, as a first step in building a geometrical model that bridges together higher dimensional representations, quasicr...
Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury via MAPK pathway
Cytokine, 2021
BACKGROUND Hepatic ischemia/reperfusion (I/R) injury is a major complication of liver resection o... more BACKGROUND Hepatic ischemia/reperfusion (I/R) injury is a major complication of liver resection or transplantation. However, the mechanism underlying hepatic I/R injury remains obscure. The aim of the present study was to investigate the role of Chemokine-like factor 1 (CKLF1) in hepatic I/R injury. METHODS Rats were subjected to 70% hepatic ischemia for 90 min, followed by 6, 12, 24, 48 and 96 h of reperfusion. The expression of CKLF1 was measured by real-time PCR and western blot. The effect of C19, an antagonism peptide of CKLF1, on hepatic I/R injury was investigated. RESULTS After subjected to 70% hepatic ischemia and reperfusion, the ALT and AST were increased. H&E results showed serious liver damage. The mRNA and protein levels of CKLF1 expression were upregulated during hepatic I/R. Immunohistochemistry staining results showed that neutrophil infiltration was increased in the ischemia lobe. MPO activity was significantly higher post reperfusion. TNF-α and IL-1β were upregulated during hepatic I/R. C19 administration significantly reduced the level of ALT and AST, decreased the necrosis area of liver tissue. Furthermore, C19 treatment inhibited neutrophil infiltration and reduced MPO activity. Meanwhile, C19 decreased the expression of TNF-α and IL-1β. The phosphorylation of P38, JNK were inhibited by C19 treatment. CONCLUSION CKLF1 was upregulated during hepatic I/R. Inhibiting CKLF1 by C19, an antagonism peptide of CKLF1, could alleviate hepatic I/R injury, reduce neutrophil infiltration, decrease inflammatory response. The protective effect of C19 may related to MAPK signaling pathway.
The Boerdijk–Coxeter helix is a helical structure of tetrahedra which possesses no non-trivial tr... more The Boerdijk–Coxeter helix is a helical structure of tetrahedra which possesses no non-trivial translational or rotational symmetries. In this document, we develop a procedure by which this structure is modified to obtain both translational and rotational (upon projection) symmetries along/about its central axis. We show by construction that a helix can be obtained whose shortest period is any whole number of tetrahedra greater than one except six, while a period of six necessarily entails a shorter period. We give explicit examples of two particular forms related to the pentagonal and icosahedral aggregates of tetrahedra as well as Buckminster Fuller’s “jitterbug transformation”.
In this paper, we present the construction of several aggregates of tetrahedra. Each construction... more In this paper, we present the construction of several aggregates of tetrahedra. Each construction is obtained by performing rotations on an initial set of tetrahedra that either (1) contains gaps between adjacent tetrahedra, or (2) exhibits an aperiodic nature. Following this rotation, gaps of the former case are “closed” (in the sense that faces of adjacent tetrahedra are brought into contact to form a “face junction”), while translational and rotational symmetries are obtained in the latter case. In all cases, an angular displacement of β = arccos 3 ϕ − 1 / 4 (or a closely related angle), where ϕ = 1 + 5 / 2 is the golden ratio, is observed between faces of a junction. Additionally, the overall number of plane classes, defined as the number of distinct facial orientations in the collection of tetrahedra, is reduced following the transformation. Finally, we present several “curiosities” involving the structures discussed here with the goal of inspiring the reader’s interest in cons...
Uploads
Papers by Fang Fang Li