Journal of clinical and diagnostic research : JCDR, 2015
Different topical formulations of diclofenac have varying skin penetration profile. Recent advanc... more Different topical formulations of diclofenac have varying skin penetration profile. Recent advances in science and technology has led to the development of many new formulations of drugs for topical drug delivery. One such technological development has led to the innovation of Dynapar QPS, a novel, non-aqueous, quick penetrating solution (QPS) of diclofenac diethylamine. This study was aimed to measure the total exposure from the drug penetrating the skin in healthy human subjects and comparing the relative systemic bioavailability of Dynapar QPS(®) with diclofenac emulgel. A 200 mg of diclofenac from either Dynapar QPS(®) (5 ml) or emulgel (20 g) was applied on back of subject as per the randomisation schedule. Blood samples were collected up to 16 hours post drug application. Plasma concentration of diclofenac was measured by pre-validated HPLC method. Pharmacokinetic (PK) parameters like Cmax, Tmax, t1/2, AUC0-t, AUC0-∞, and Kel, of diclofenac were determined for both the formula...
Over the years a lot of work has done and is still continuing with great effort to save weight an... more Over the years a lot of work has done and is still continuing with great effort to save weight and cost of applications. The current trend is to provide weight/cost effective products which meet the stringent requirements. The belt conveyor is an endless belt moving over two end pulleys at fixed positions and used for transporting material horizontally or at an incline up or down. Allow quick and efficient transportation for a wide variety of materials. Diverter car belt conveyors are used to transfer concrete horizontally and limited distance vertically. They are particularly useful in areas such as dam slabs where it is difficulty to put concrete at mid side of the river at specific point, bridge, tunnels where space is limited and where it is difficulty to put concrete at specific point, Bridge grader making. A 25 meter cantilever belt conveyor is used in the diverter car belt conveyor system. The supporting the belt conveyor system is called belt conveyor supporting structure. Structure that supports and maintains the alignments of the idlers and pulleys a nd support the driving machinery. Goal of the project is to study existing conveyor system and optimize dead weight, structures optimize to minimize the overall weight of assembly and material saving can withstand such loads. The design of supporting structure can be make safe. With the help of SOLIDWORK for modeling and ANSYS 14.5 for analysis we analyzed the whole system.
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