Papers by Devinder Thappa
Sebaceoma
Cosmoderma, Jun 19, 2021
Multiple dermatofibromas with unusual features
Indian Journal of Dermatology, Venereology and Leprology, Mar 1, 1995
A 51-year-old-male with multiple dermatofibromas over both elbows and feet is reported for its ra... more A 51-year-old-male with multiple dermatofibromas over both elbows and feet is reported for its rarity and unusual features.
Darter's Disease with Multiple Verrucae
Journal of Dermatology, Oct 1, 2000
Postgraduate Medical Journal, Aug 1, 2000
Children with chronic inflammatory bowel disease in the UK are still often cared for by general p... more Children with chronic inflammatory bowel disease in the UK are still often cared for by general paediatricians with the assistance of adult gastroenterologists or surgeons. This is not the case in North America or much of Europe. Juvenile onset Crohn's disease is an increasing problem as a recent report from Scotland indicates. 1 Both diagnosis and management are complex and the time has come for all children with these disorders to be at least reviewed in a tertiary centre for paediatric gastroenterology 2 in order to improve the delivery of care. There is clearly an important genetic aspect to inflammatory bowel disease. There is some evidence that genetic anticipation may occur to explain the tendency for children to be younger than their parents at diagnosis but some relate this to ascertainment. 3 Delay in diagnosis is a common feature in these children. 4 It is often considered that partial or inadequate diagnosis is enough. Children deserve the same comprehensive diagnostic approach as is available to adults in order to plan rational management. After all, these disorders are likely to be life long. When cared for initially by adult physicians or gastroenterologists, vital measurement of height and grading of puberty are often not done. Accurate diagnosis and eVective treatment are both essential for ideal management. Smooth transfer to adult clinics in due course is essential.
Prevalence of metabolic syndrome in south indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: A hospital-based case-control study or cross-sectional study?
Indian Journal of Dermatology, 2013
Ichthyosis hystrix
PubMed, Feb 1, 2003
Editor's remarks
Indian Journal of Dermatology, Venereology and Leprology, 2009
Leiomyoma Cutis : A Report Of Two Cases
Indian Journal of Dermatology, Jul 1, 1998
ABSTRACT
Chondroid syringoma of the eyebrow and elbow
Indian Journal of Dermatology, 2006
Disability grading in leprosy: current status
PubMed, Jul 1, 1994
The systems of classification and grading of disabilities in leprosy patients, suggested by WHO a... more The systems of classification and grading of disabilities in leprosy patients, suggested by WHO and others are reviewed. Taking into account the drawbacks observed in these classifications, a new system of grading of disabilities of hands and feet of leprosy patients based on the 1960 WHO classification is proposed for use in institutions.
Scrotal lesions in lepromatous leprosy
PubMed, Oct 3, 1999
Giant Cutaneous Horn
Indian Journal of Dermatology, Jul 1, 2000
ABSTRACT
A Family with An Overlap Of Acropigmentation Of Kitamura And Dowling Degos Disease
Indian Journal of Dermatology, Oct 1, 1999
ABSTRACT
Cryoglobulins and rheumatoid factor in leprosy
Indian journal of leprosy, 2004
Dermoscopy in the diagnosis of generalized acute cutaneous lupus erythematosus
International Journal of Dermatology, Jan 7, 2021
described in the literature over the past 30 years. Of those, only six occurred in females under ... more described in the literature over the past 30 years. Of those, only six occurred in females under 72 years old and the majority in HIV positive patients. The etiopathogenesis of nodular syphilis remains unclear, but it may correspond to late stage secondary syphilis before the transition to tertiary syphilis, or it may result from a hypersensitivity reaction to the infection by Treponema pallidum. Most of the reported cases presented disseminated red-purple patches, nodules, and plaques, predominantly on the face, trunk, and upper limbs, with sparing of the palmoplantar region. These clinical aspects are different from the ones in our patient, in whom nodular lesions were located on the legs, with palmoplantar brownish macules also being present. Differential diagnosis of secondary nodular syphilis includes numerous pathologies, such as Kaposi’s sarcoma, lymphoma, or fungal/mycobacterial infections. Histologic features of nodular syphilis vary and may include a superficial and deep perivascular plasma cell infiltrate and epidermal hyperplasia as in our case. However, non-necrotizing granulomas and endarteritis are occasionally observed. Even though immunohistochemistry studies using antibodies to treponemal antigens were negative, serology results were sufficient to establish a definitive syphilis diagnosis. Negative immunochemistry studies can occur due to longstanding secondary syphilis or previous antibiotic treatment regimens. Gold-standard treatment for secondary syphilis consists in a single intramuscular injection of PB. However, most of the reported cases refer a better outcome with the administration of three PB doses. As such, and considering that the disease duration was unknown, three doses were administered. Herein, we present a unique case of nodular syphilis in an 83-year-old immunocompetent patient. We highlight that syphilis should always be kept in mind as a great mimicker of numerous cutaneous skin diseases, and this diagnosis should be elicited regardless of the patient’s age. A meticulous clinical history with sexually transmitted disease screening should always be undertaken, especially considering the alarming increase in sexual transmitted diseases affecting older-aged groups documented over the last decade.
Topical therapy in vitiligo: What is new?
Pigment international, 2016
Prescribing practices of tranexamic acid for melasma: Delphi consensus from the Pigmentary Disorders Society
Indian Journal of Dermatology, Venereology and Leprology, Jul 21, 2023
Introduction There is ambiguity regarding usage of tranexamic acid for melasma in India, be it in... more Introduction There is ambiguity regarding usage of tranexamic acid for melasma in India, be it in its pre-administration evaluation, administration route, dosing or monitoring. Hence, we conducted this study to understand various tranexamic-acid prescribing patterns and provide practical guidelines. Materials and methods A Google-form-based questionnaire (25-questions) was prepared based on the key areas identified by experts from the Pigmentary Disorders Society, India and circulated to practicing dermatologists across the country. In rounds 2 and 3, the questionnaire was re-presented to the same group of experts and their opinions were sought. The results of the practitioners’ survey were denoted graphically alongside, to guide them. Consensus was deemed when at least 80% of respondents chose an option. Results The members agreed that history pertaining to risk factors for thromboembolism, cardiovascular and menstrual disorders should be sought in patients being started on oral tranexamic-acid. Baseline coagulation profile should be ordered in all patients prior to tranexamic-acid and more exhaustive investigations such as complete blood count, liver function test, protein C and S in patients with high risk of thromboembolism. The preferred oral dose was 250 mg orally twice daily, which can be used alone or in combination with topical hydroquinone, kojic acid and sunscreen. Repeated dosing of tranexamic-acid may be required for those relapsing with melasma following initial tranexamic-acid discontinuation. Coagulation profile should ideally be repeated at three monthly intervals during follow-up, especially in patients with clinically higher risk of thromboembolism. Treatment can be stopped abruptly post improvement and no tapering is required. Limitation This study is limited by the fact that open-ended questions were limited to the first general survey round. Conclusion Oral tranexamic-acid provides a valuable treatment option for melasma. Frequent courses of therapy may be required to sustain results and a vigilant watch is recommended for hypercoagulable states during the course of therapy.
Ulcerated nodule over the chest
PubMed, Jul 24, 2007
Significance of cutaneous manifestations of COVID-19
Cosmoderma, May 17, 2021
The COVID-19 pandemic has brought the whole world to a grinding halt. With the pandemic still ong... more The COVID-19 pandemic has brought the whole world to a grinding halt. With the pandemic still ongoing, it is worthwhile to recapitulate the cutaneous manifestations for dermatologists, their significance, and spectrum of COVID-19 disease. COVID-19 is a highly contagious respiratory tract disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first reported on December 1, 2019, from Wuhan, China and was declared a pandemic by the World Health Organization on March 11, 2020. COVID-19 indirectly involves the skin just like any other viral infection and is independent of the disease stage or severity. Cutaneous manifestations of COVID-19 may present a few days before or after the first general symptoms of the disease. The appearance of cutaneous manifestations before early respiratory symptoms can promote early recognition of COVID-19 in such cases. The pathophysiology of cutaneous lesions in COVID-19 is still unclear. It is attributed to immune dysregulation, vasculitis, vessel thrombosis, neogenesis, hypercoagulable states, or simple hypersensitivity in COVID-19. Endothelial swelling with the presence of SARS-CoV-2 viral particles in the endothelial cells has also been seen on electron microscopy. Thus, the clinical features indicative of viral exanthems/enanthems which can be found in other diseases therefore fail to provide specific clues for diagnosis and prognosis of COVID-19. On the other hand, vasculopathy-related skin manifestations may provide prognostic values by indicating severe complications due to COVID-19 and may help in monitoring disease severity. Early detection of cutaneous signs associated with severe disease is crucial to improve patient outcomes.
Letter To Editor-Anti-aging therapies: Other half of the story
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Papers by Devinder Thappa