Papers by Peter Braithwaite
Geological Society, London, Engineering Geology Special Publications, 1988
The West Midlands of England has a long history of industrial production and attendant mineral ex... more The West Midlands of England has a long history of industrial production and attendant mineral extraction. With the decline in heavy industry, the region has suffered from the effects of dereliction arising from both surface and subsurface causes. The effects of surface dereliction are evident from the hundreds of hectares of land once occupied by factories and heavy industrial and manufacturing complexes, which now lie neglected. Subsurface dereliction arises from the risk of collapses within the abandoned mineral workings causing subsidence or collapse at the surface. This risk has affected many hectares of land, both industrial and residential and is restricting efforts to redevelop and regenerate the region.A recent initiative, led by the Department of Environment and the Black Country Boroughs of Dudley, Sandwell, Walsall and Wolverhampton has enabled the problems associated with old limestone workings to be studied over the past six years. The techniques used to locate the min...
Changing Trends in Breast Carcinoma 1,*,5
Anz J Surg, 1980
Page 1. CHANGING TRENDS IN BREAST CARCINOMA BRAITHWAITE ET ALll CHANGING TRENDS IN BREAST CARCINO... more Page 1. CHANGING TRENDS IN BREAST CARCINOMA BRAITHWAITE ET ALll CHANGING TRENDS IN BREAST CARCINOMA' PETER A. BRAITHWAITE,' PAUL M. BOLTON,3 and DACE SHUGG4 Department of Surgery, University of Tasmania ...
Clostridial myonecrosis after resection of skin tumours in an immunosuppressed patient
The Medical journal of Australia, Jan 12, 1982
This paper reports a case of clostridial myonecrosis (gas gangrene) which occurred in a vegetable... more This paper reports a case of clostridial myonecrosis (gas gangrene) which occurred in a vegetable gardener receiving immunosuppression therapy with prednisolone and azathioprine for renal allograft preservation. The infection developed after the excision of crusted squamous-cell carcinomata from the dorsum of the hand, the circulation of which was compromised by the presence of a radial artery/cephalic vein arteriovenous fistula. Amputation, followed by treatment with hyperbaric oxygen, was successful.
Cyst and host tissue concentrations of mebendazole in patients undergoing surgery for hydatid disease
The Medical journal of Australia, Jan 15, 1983
Mebendazole levels were assayed by high performance liquid chromatographic assay in plasma, host ... more Mebendazole levels were assayed by high performance liquid chromatographic assay in plasma, host tissues, and hydatid material taken from four patients who underwent surgery for hydatid disease. The drug was absorbed and had penetrated both into the host and into the parasite material. The levels of the drug in viable hydatid cysts were much lower than those in dead cysts. The possibility of exclusion or detoxification of the drug by viable hydatid cysts is raised.
Hepatic hydatid disease presenting as pancreatitis
The Medical journal of Australia, Jan 15, 1983
Hydatid Disease and Albendazole
The Lancet, 1984
Volvulus of the splenic flexure of colon: a case report and review
International Journal of Colorectal Disease, 2000
We report a case of splenic flexure volvulus in a patient who had previously been operated upon f... more We report a case of splenic flexure volvulus in a patient who had previously been operated upon for a sigmoid volvulus. The clinical features and management of splenic flexure volvulus are discussed.
European Journal of Clinical Pharmacology, 1982
The plasma concentrations of mebendazole and its metabolites have been monitored in twelve patien... more The plasma concentrations of mebendazole and its metabolites have been monitored in twelve patients after receiving a 10 mg/kg dose for cystic hydatid disease. The mebendazole plasma concentration-time profiles differed considerably between patients; elimination half-lives ranged from 2.8-9.0 h, time to peak plasma concentration after dosing ranged from 1.5-7.25 h and peak plasma concentrations ranged from 17.5 to 500 ng/ml. The mean peak plasma concentration of mebendazole after an initial dose (69.5 ng/mt) was lower than found in patients during chronic therapy (137.4 ng/ml). The plasma AUCTs for the major metabolites of mebendazole (methyl 5-(a-hydroxybenzyl)-2-benzimidazole carbamate and 2-amino-5 benzoylbenzimidazole) were about five times the plasma AUCT found for mebendazole in patients on chronic therapy. It is suggested that the slower clearance of these polar metabolites relative to mebendazole results from enterohepatic recycling. Since mebendazole is also highly plasma protein bound, caution should be observed in administering mebendazole to patients with liver disease. Concentrations of mebendazole found in the tissue and cyst material collected from two patients during surgery ranged from 59.5 to 206.6 ng/g wet weight.
Long-Term High-Dose Mebendazole for Cystic Hydatid Disease of Liver: Failure in Two Cases
ANZ Journal of Surgery, 1981
Mebendazole was given as definitive therapy to four patients with cystic hydatid disease of the l... more Mebendazole was given as definitive therapy to four patients with cystic hydatid disease of the liver who were later explored surgically. Viable hydatid material was removed from two patients after continuous therapy with 40 mg/kg/day for eight and three months respectively. The hydatid material was necrotic in the other two patients. This drug appeared to be ineffective as definitive treatment of two of these four patients with established hydatid disease of the liver.
ANZ Journal of Surgery, 1985
The alveolar form of hydatid disease, caused by the larval stage of the cestode Echinococcus mulr... more The alveolar form of hydatid disease, caused by the larval stage of the cestode Echinococcus mulriloculuris, is virtually confined geographically to the northern hemisphere. It produces clinically malignant multivesicular infiltrating lesions most often in the liver, and is quite different from the usual cystic variety caused by E. grunulosus. We present a case report of a patient with alveolar hydatid disease, whose treatment with, mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.
Hydatid Disease: Epidemiology and Pathology
ANZ Journal of Surgery, 1983
Information regarding the epidemiology and pathology of Echinococcus granulosus in Australasia is... more Information regarding the epidemiology and pathology of Echinococcus granulosus in Australasia is not well presented in standard surgical textbooks. This review presents the basic science of E. granulosus in Australasia, emphasizing those areas which are not well known, are misunderstood, or are of particular relevance to current surgical practice.
Changing Trends in Breast Carcinoma 1,*,5
ANZ Journal of Surgery, 1980
Page 1. CHANGING TRENDS IN BREAST CARCINOMA BRAITHWAITE ET ALll CHANGING TRENDS IN BREAST CARCINO... more Page 1. CHANGING TRENDS IN BREAST CARCINOMA BRAITHWAITE ET ALll CHANGING TRENDS IN BREAST CARCINOMA' PETER A. BRAITHWAITE,' PAUL M. BOLTON,3 and DACE SHUGG4 Department of Surgery, University of Tasmania ...
The Value of the Hickman-Type Right Atrial Catheter for Venous Access in Cancer Patients
ANZ Journal of Surgery, 1981
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Papers by Peter Braithwaite