Papers by Ayu Savitri Siskayani
The Indonesian Biomedical Journal, 2020
BACKGROUND: Statin is an anti-cholesterol drug that is widely prescribed throughout the world. St... more BACKGROUND: Statin is an anti-cholesterol drug that is widely prescribed throughout the world. Statins are mainly used to treat and prevent cardiovascular disease. Several studies have found the pleiotropic effect of statin. However, related effect of statin in kidney failure is still unclear. Ischemic-reperfusion (I/R) injury is a major cause of acute kidney failure. This study aims to determine the effect of simvastatin on kidney function and glomerular conditions by periodic acid-schiff staining in I/R injury.METHODS: Eighteen male Swiss mice were grouped into sham operation group (GSO), I/R injury group (GIRI), and simvastatin group (GSIM). The GSO group was performed by sham operation and pretreatment of 1% carboxymethylcellulose (CMC) for 3 days. The GIRI group was performed by I/R procedure and pretreatment of 1% CMC for 3 days and the GSIM group was performed by I/R procedure and pretreatment of 10 mg/kg BW simvastatin for 3 days. Blood urea nitrogen (BUN) and creatinine ser...
Biology, Medicine, & Natural Product Chemistry
In this study we reported cultivation of bacteria associated with mangrove soil from the Ngurah R... more In this study we reported cultivation of bacteria associated with mangrove soil from the Ngurah Rai Mangrove Forest, Bali. Mangrove soil samples were serially diluted using sterile artificial seawater, spread onto Starch Casein M agar and incubated at 28oC for 28 days. Cultivation of mangrove soil samples yielded 165 bacterial colonies with 68 isolates were selected and purified based on different morphology. Of these 68 isolates, 22 isolates displayed antibacterial activities ranging from weak to strong inhibition against at least one of four bacterial indicators namely Staphyloccocus aureus, Streptococus mutans, Escherichia coli and Klebsiella pneumoniae using perpendicular streak method. Overall, 19 out of 22 bacteria isolates displayed weak antibacterial potential and two isolates exhibited moderate antibacterial activity. The isolate SA4 was the only bacterium with strong antibacterial potential with measured clear distance ≥ 10 mm against the four bacterial isolates. Sequenc...
Dengue virus infection is still one of the health problems in tropical and subtropical regions. I... more Dengue virus infection is still one of the health problems in tropical and subtropical regions. In its pathogenesis, some cytokines play an important role in the natural and adaptive immune response to the severity of dengue virus infection. Replication of dengue virus that activates macrophages will release cytokines for tumor necrosis factor (TNF-α), interleukin-1 (IL-1) and interleukin-12 (IL-12). This study aims to determine whether there are differences in mean TNF-α levels in DF and DHF patients. This study is an analytic observational study using cross-sectional design, where blood samples were taken from 27 people with DF and 27 people with DHF. Serum TNF-α levels were analyzed with ELISA and TNF-α levels were analyzed statistically with Mann-Whitney test. The results showed the mean TNF-α level in DF patients was 76.82 ± 1.20 pg/ mL and in DHF patients was 195.15 ± 30.30 pg/mL. This mean differed significantly (p <0.05). Based on the results of the study it can be conclu...
Ikan nila berasal dari Sungai Nil di Afrika Utara dan masih berkerabat dekat dengan ikan mujair s... more Ikan nila berasal dari Sungai Nil di Afrika Utara dan masih berkerabat dekat dengan ikan mujair sehingga mempunyai sifat yang hampir sama (Sugiarto, 1988). Oreochromis niloticus termasuk familia Ciclidae, sama seperti ikan nila hitam dan mujair. Ikan nila merah diduga hasil perkawinan silang antara Oreochromis niloticus atau Oreochromis mosambicus dengan Oreochromis hornorum, Oreochromis aureus atau Oreochromis zilii (Santoso, 1996). Nila merupakan ikan yang sangat populer dibudidayakan, dengan keunggulan yaitu cara membudidayakannya mudah, tahan terhadap penyakit sesuai dengan iklim tropis, memiliki nilai ekonomi yang cukup tinggi. Hal ini dikarenakan ikan tersebut merupakan komoditas ikan air tawar yang memperoleh banyak perhatian dari pemerintah dan pemerhati masalah perikanan dunia, terutama dalam hal peningkatan gizi masyarakat di negara-negara yang sedang berkembang. Berbagai upaya penelitian dengan tujuan memperoleh ikan nila yang produktif terus dilakukan khususnya di Indonesia. Bibit ikan didatangkan ke Indonesia secara resmi oleh Balai Penelitian Perikanan Air Tawar pada tahun 1969. Setelah melalui masa penelitian dan adaptasi, barulah ikan ini disebarluaskan kepada petani di seluruh Indonesia. Nila adalah nama khas Indonesia yang diberikan oleh Pemerintah melalui Direktur Jenderal Perikanan. Budidaya ikan nila dewasa ini banyak dikembangkan berbagai teknologi dalam rangka peningkatan mutu induk ikan nila. Hal ini disebabkan pada saat ini telah banyak terjadi penurunan kualitas induk ikan nila. Oleh karena itu kebutuhan induk bermutu sangat diharapkan dalam rangka memperoleh benih yang berkualitas. Ikan nila merupakan salah satu jenis ikan air tawar yang termasuk dalam program revitalisasi perikanan budidaya yang dicanangkan oleh pemerintah. Oleh karena itu, perlu dilakukan suatu upaya dalam meningkatkan kualitas induk dan benih ikan nila yang beredar di masyarakat. dan Balai Benih Ikan Denpasar, diperoleh hasil pengamatan sebagai berikut: No Hasil Pengamatan Keterangan
Pantai adalah sebuah bentuk geografis yang terdiri dari pasir, dan terdapat di daerah pesisir lau... more Pantai adalah sebuah bentuk geografis yang terdiri dari pasir, dan terdapat di daerah pesisir laut. Daerah pantai menjadi batas antara daratan dan perairan laut. Panjang garis pantai ini diukur mengeliling seluruh pantai yang merupakan daerah teritorial suatu negara.
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Papers by Ayu Savitri Siskayani