Eswar Rao Tatta

Indian Institute of Science, Biological Sciences, Post-Doc

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I am Dr Eswara Rao Tatta, FSMBB, a passionate microbiology researcher with over 9 years of experience in infectious diseases, antimicrobial resistance, biofilm research, and drug discovery. I hold a PhD in Microbial Genomics and have published my research in reputable journals, including Frontiers in Systems Biology, Gene, Microbial Pathogenesis, Applied Microbiology and Biotechnology, and Current Topics in Medicinal Chemistry. I am driven by a deep interest in tackling complex scientific problems, particularly those related to antimicrobial resistance, which is one of the most critical challenges in global health today.

My technical skills span molecular biology, animal facility management, genome biology, cell culture, bioinformatics, and microscopy. I am proficient in scientific writing, data analysis, and experimental design, and I always strive for excellence in both research and education. I’m eager to contribute to novel, impactful scientific projects and to support young minds in their learning and research journeys.

Throughout my career, I have delivered over 50 invited talks and training sessions both online/onsite, covering topics in microbiology, natural compounds, and computational biology. These experiences have strengthened my skills in scientific communication and mentoring. I’ve also had the opportunity to teach and guide students, faculty, and industry professionals, and I’m highly motivated to continue bridging the gap between academic research and industrial application.

I am actively seeking opportunities to collaborate, teach, and contribute to cutting-edge research that makes a real-world difference.

Key Competencies:
• Infectious Diseases & Antimicrobial Resistance
• Biofilm Research & Drug Discovery
• Molecular Biology & Microbial Genomics
• Microscopy (CLSM, SEM), Cell Culture & Cytotoxicity
• Animal Handling & In Vivo Studies
• Bioinformatics & Computational Biology
• Scientific Writing, Teaching & Public Speaking
Supervisors: Dr. Ranjith Kumavath and Dr. Sambashiva Rao and Dr. Mahavir singh
Phone: 9550090133
Address: Under graduate Programm office, Indian Institute of Science, CV Raman Rd, Bengaluru, Karnataka 560012

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Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria

Irrational antibiotic use contributes to the development of antibiotic resistance in bacteria, wh... more Irrational antibiotic use contributes to the development of antibiotic resistance in bacteria, which is a major cause of healthcare-associated infections globally. Molecular research has shown that multiple resistance frequently develops from the uptake of pre-existing resistance genes, which are subsequently intensified under selective pressures. Resistant genes spread and are acquired through mobile genetic elements which are essential for facilitating horizontal gene transfer. MGEs have been identified as carriers of genetic material and are a significant player in evolutionary processes. These include insertion sequences, transposons, integrative and conjugative elements, plasmids, and genomic islands, all of which can transfer between and within DNA molecules. With an emphasis on pathogenic bacteria, this review highlights the salient features of the MGEs that contribute to the development and spread of antibiotic resistance. MGEs carry non-essential genes, including AMR and virulence genes, which can enhance the adaptability and fitness of their bacterial hosts. These elements employ evolutionary strategies to facilitate their replication and dissemination, thus enabling survival without positive selection for the harboring of beneficial genes.

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Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria

Unraveling the role of mobile genetic, 2025

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Microbial-Mediated Remediation of Environmental Contaminants by Integrated Multi OMIC’s Approaches

Springer eBooks, 2021

The global environment offers everything like good health, good food, to the human population. Th... more The global environment offers everything like good health, good food, to the human population. Therefore, optimization for efficient bioremediation requires augmentation of complex input to minimize the environmental contaminants. These pollutants hold toxic molecules that influence the ecosystem and existing living things, the forthcoming effects could be devastating to human populations and the environment. Moreover, bioremediation is an option to enhance the efficacy of the natural biodegradation process by using living microbes, which can degrade the toxic compound into less or non-toxic forms. This chapter focused on OMIC’s approaches bringing paradigm swift in understanding microbial sources and their application in the bioremediation for cleaning the environment.

Transcriptome analysis revealed the synergism of novel rhodethrin inhibition on biofilm architecture, antibiotic resistance and quorum sensing inEnterococcus faecalis

Gene, Jun 1, 2023

Bioprospecting of microbial enzymes: current trends in industry and healthcare

Applied Microbiology and Biotechnology, Mar 1, 2022

Microbial enzymes have an indispensable role in producing foods, pharmaceuticals, and other comme... more Microbial enzymes have an indispensable role in producing foods, pharmaceuticals, and other commercial goods. Many novel enzymes have been reported from all domains of life, such as plants, microbes, and animals. Nonetheless, industrially desirable enzymes of microbial origin are limited. This review article discusses the classifications, applications, sources, and challenges of most demanded industrial enzymes such as pectinases, cellulase, lipase, and protease. In addition, the production of novel enzymes through protein engineering technologies such as directed evolution, rational, and de novo design, for the improvement of existing industrial enzymes is also explored. We have also explored the role of metagenomics, nanotechnology, OMICs, and machine learning approaches in the bioprospecting of novel enzymes. Overall, this review covers the basics of biocatalysts in industrial and healthcare applications and provides an overview of existing microbial enzyme optimization tools. KEY POINTS: • Microbial bioactive molecules are vital for therapeutic and industrial applications. • High-throughput OMIC is the most proficient approach for novel enzyme discovery. • Comprehensive databases and efficient machine learning models are the need of the hour to fast forward de novo enzyme design and discovery.

Rhodethrin and Rubrivivaxin as potential source of anti-biofilm agents against vancomycin resistant Enterococcus faecalis (ATCC 19443)

Microbial Pathogenesis, Nov 1, 2020

Enterococcus faecalis is frequently present in the hospital environment and readily forms a biofi... more Enterococcus faecalis is frequently present in the hospital environment and readily forms a biofilm that protects from antibiotics and resistance against environmental stress conditions, thereby increasing nosocomial chronic infections. This study aims to assess antimicrobial and antibiofilm activities of two novel terpenoid derivatives Rhodethrin (Rdn) and Rubrivivaxin (Rbn) against vancomycin resistant Enterococcus faecalis strain (ATCC19443). Both terpenoids effectively prevent biofilm formation with >75% attenuation in cell biomass and significantly decrease the production of exopolysaccharides (EPSs) (p = 0.005) and besides their expansion on different surface media. The findings provide new evidence that such terpenoid derivatives could be developed as novel antibacterial drugs.

Marine Enzymes: Production and Applications for Human Health

Advances in food and nutrition research, 2017

Marine microbial enzymes have wide applications in bioindustries. Selection of microorganisms for... more Marine microbial enzymes have wide applications in bioindustries. Selection of microorganisms for enzyme production at the industrial level requires good yield and high production rate. A number of enzymes such as amylase, caseinase, lipase, gelatinase, and DNases have been discovered from microbes isolated from extreme marine environments. Such enzymes are thermostable, tolerant to a varied range of pH and other harsh conditions required in industrial applications. Novelty in their structure and characteristics has shown promising scope to the researchers in academia and industry. In this chapter, we present a bird's eye view on recent research works in the field of enzyme production from marine origin as well as their potential biological applications relevant to human health.

Attenuation of Enterococcus faecalis biofilm formation by Rhodethrin: A combinatorial study with an antibiotic

Microbial Pathogenesis, Feb 1, 2022

The nosocomial pathogen Enterococcus faecalis critically implicated in the hospital environment. ... more The nosocomial pathogen Enterococcus faecalis critically implicated in the hospital environment. Its major virulence attributes biofilm formation and antibiotic resistance. The novel therapeutics are required to inhibit E. faecalis biofilm formation and virulence. Thus combinatorial and drug repurposing has been promising approaches to tackling biofilm-associated infections. Here, we have used a bacterium that produced indole terpenoid Rhodethrin (Rdn) with a combination of known antibiotic chloramphenicol (Chpl) against E. faecalis (ATCC 19433). The fractional inhibitory concentration index (FICI) values showed between 0.25 and 0.33 synergistic activities. The exopolysaccharides (EPSs) production significant decrease with Rdn (34.6 ± 4.6%), Chpl (31.0 ± 5.2%), and combination (Rdn-Chpl) (76.0 ± 4.5%) (p > 0.05). However, the biofilm interruption can attenuate of total bioﬁlm was shown with Rdn (39.7 ± 5.1%), Chpl (32.6 ± 4.7%), and Rdn-Chpl (69.0 ± 5.3%), (p > 0.05). The microscopic observations reveal that the gradually unstructured biofilm architecture in E. faecalis. Furthermore, in silico, studies on biofilm-associated proteins (GelE, LuxS), virulence regulating (SprE), and cell division (FtsZ) have resulted in high and reasonable binding affinity, respectively. Thus, our results suggested that the synergism of Rdn-Chpl has the potential to function as a combinatorial antibiotic accelerates in treating vancomycin-resistant Enterococcus faecalis infections.

Marine Enzymes: Production and Applications for Human Health

This chapter was originally published in the book Advances in Food and Nutrition Research, Vol. 8... more This chapter was originally published in the book Advances in Food and Nutrition Research, Vol. 80 published by Elsevier, and the attached copy is provided by Elsevier for the author's benefit and for the benefit of the author's institution, for non-commercial research and educational use including without limitation use in instruction at your institution, sending it to specific colleagues who know you, and providing a copy to your institution's administrator.

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Bioprospecting of microbial enzymes: current trends in industry and healthcare

Microbial enzymes have an indispensable role in producing foods, pharmaceuticals, and other comme... more Microbial enzymes have an indispensable role in producing foods, pharmaceuticals, and other commercial goods. Many novel enzymes have been reported from all domains of life, such as plants, microbes, and animals. Nonetheless, industrially desirable enzymes of microbial origin are limited. This review article discusses the classifications, applications, sources, and challenges of most demanded industrial enzymes such as pectinases, cellulase, lipase, and protease. In addition, the production of novel enzymes through protein engineering technologies such as directed evolution, rational, and de novo design, for the improvement of existing industrial enzymes is also explored. We have also explored the role of metagenomics, nanotechnology, OMICs, and machine learning approaches in the bioprospecting of novel enzymes. Overall, this review covers the basics of biocatalysts in industrial and healthcare applications and provides an overview of existing microbial enzyme optimization tools. Key points • Microbial bioactive molecules are vital for therapeutic and industrial applications. • High-throughput OMIC is the most proficient approach for novel enzyme discovery. • Comprehensive databases and efficient machine learning models are the need of the hour to fast forward de novo enzyme design and discovery.

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Transcriptome analysis revealed the synergism of novel rhodethrin inhibition on biofilm architecture, antibiotic resistance and quorum sensing inEnterococcus faecalis

Gene

Bioprospecting of microbial enzymes: current trends in industry and healthcare

Applied Microbiology and Biotechnology, 2022

Microbial-Mediated Remediation of Environmental Contaminants by Integrated Multi OMIC’s Approaches

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1, 2021

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Rhodethrin and Rubrivivaxin as potential source of anti-biofilm agents against vancomycin resistant Enterococcus faecalis (ATCC 19443)

Microbial Pathogenesis

Eswar Rao Tatta

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