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de-orphaned

[edit]

Hi. Please remove the orphan tag from this article. I have created a link from this article. HRShami (talk) 11:04, 14 July 2025 (UTC)[reply]

 Done Encoded  Talk 💬 07:48, 16 July 2025 (UTC)[reply]

Research section

[edit]

Based on the tags on the page, I have changed some references and provided details here of where each statement is taken from. Please note his name is misspelled in some references as Izzoti or Izotti.

Please replace the current research section with the text below. The details of the exact sentences in the reference will need to be removed before placing the text on the page. If a volunteer reviews this and allows me, I can update the research section.

In his research related to chemoprevention and cancer, Izzotti studied the effectiveness of chemopreventive drugs in preventing cancer and other mutation-related diseases. He studied the mechanisms through which these drugs work, particularly in relation to smoking-related outcomes. He showed that these medicines can reduce DNA damage and other cancer related effects in preclinical models.[page 26, paragraph 2] [1]

Izzotti also investigated how microRNA (miRNA), which are small molecules that regulate gene expression, respond to noxious agents in healthy tissues. His studies demonstrated that miRNA impairment in lungs is induced by exposure to cigarette smoke. [page 2, paragraph 2] [2] He also found that miRNA alterations occur as an early response in the tissue of cells exposed to environmental carcinogens before the onset of cancer. [page 24, introduction, paragraph 3] [3] In related research, he also deduced the presence of extra-cellular miRNAs in biological fluids in order to determine their feasibility as potential cancer markers that can be detected through non-invasive procedures. [page 4, paragraph 4 and paragraph 6] [4] It was then found that some panels of miRNAs can emerge as cancer biomarkers, [please search reference 42] but there is a need to identify more specific and reliable miRNA panels. [page 5, second last paragraph] [5] In related work, Izzotti also explored the use of oral ozonized oils as a complementary therapy alongside conventional cancer treatments.[6]

Beyond cancer, Izzotti investigated the causes of the molecular mechanisms responsible for the development of glaucoma, a leading cause of irreversible blindness. He found significantly higher levels of 8-hydroxy-2′-deoxyguanosine (8-OH-dG) in the trabecular meshwork of eyes of glaucoma patients.[please search reference 103] [7] In similar research, he examined the levels of 8-OH-dG in relation to intraocular pressure, visual field damage, and disease duration. [Line 8, page 235] The results of this study found the presence of oxidative damage alongside neuronal cell death in optic nerves among patients with primary open-angle glaucoma (POAG), [line 42, page 235] which supported the possible pathogenetic role of this phenomenon. [Line 30, page 235] Correspondingly, he also analyzed the role of mitochondrial damage in the eye of POAG patients and found that mitochondrial DNA deletion was significantly increased in the human trabecular meshwork within POAG patients. [Line 40, page 235][8] HRShami (talk)

References

  1. ^ Szirmai, Mónika; Juhász, Krisztina; Bertha, András; Gombos, Katalin; Révész, Péter; Ember, István (1 April 2012). "Potential Chemopreventive Effect Of "Procont"On Mirna Expression In CBA/CA Mice". European Medical, Health and Pharmaceutical Journal. 3. doi:10.12955/emhpj.v3i0.350.
  2. ^ Russ, Rebecca; Slack, Frank J. (2012). "Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis". Pulmonary Medicine. 2012: 1–9. doi:10.1155/2012/791234.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  3. ^ Szirmai, Mónika; Juhász, Krisztina; Bertha, András; Gombos, Katalin; Révész, Péter; Ember, István (1 April 2012). "Potential Chemopreventive Effect Of "Procont"On Mirna Expression In CBA/CA Mice". European Medical, Health and Pharmaceutical Journal. 3. doi:10.12955/emhpj.v3i0.350.
  4. ^ Donzelli, Sara; Farneti, Alessia; Marucci, Laura; Ganci, Federica; Sacconi, Andrea; Strano, Sabrina; Sanguineti, Giuseppe; Blandino, Giovanni (21 April 2020). "Non-coding RNAs as Putative Biomarkers of Cancer-Associated Cachexia". Frontiers in Cell and Developmental Biology. 8: 257. doi:10.3389/fcell.2020.00257. PMC 7187787. PMID 32373612.
  5. ^ Robotti, Marzia; Scebba, Francesca; Angeloni, Debora (21 February 2023). "Circulating Biomarkers for Cancer Detection: Could Salivary microRNAs Be an Opportunity for Ovarian Cancer Diagnostics?". Biomedicines. 11 (3): 652. doi:10.3390/biomedicines11030652.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Ferrante, Margherita; Oliveri Conti, Gea; Vito, Domenico; Fernandez, Gabriela; Maione, Carol; Lauriola, Paolo; Piscitelli, Prisco; Jimenez Gomes Tagle, Melissa; Dora, Carlos; Serrano Pons, Jordi; Conforti, Carole; Panisello, Joima; Sol Ventura, Paula; Bernotti, Ilaria; Ruiz Martin, Carmen; Buloz, Edgar; Trombetta, Marcella; Banfi, Giuseppe; Tageo, Valentina (15 April 2024). "Preface and Abstracts of the 2nd International One Health Conference": 5. doi:10.3390/msf2024025005. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: unflagged free DOI (link)
  7. ^ Passaro, Maria Laura; Matarazzo, Francesco; Abbadessa, Gianmarco; Pezone, Antonio; Porcellini, Antonio; Tranfa, Fausto; Rinaldi, Michele; Costagliola, Ciro (2 November 2023). "Glaucoma as a Tauopathy—Is It the Missing Piece in the Glaucoma Puzzle?". Journal of Clinical Medicine. 12 (21): 6900. doi:10.3390/jcm12216900.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  8. ^ Majsterek, Ireneusz; Malinowska, Katarzyna; Stanczyk, Malgorzata; Kowalski, Michal; Blaszczyk, Jan; Kurowska, Anna K.; Kaminska, Anna; Szaflik, Jerzy; Szaflik, Jacek P. (April 2011). "Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma". Experimental and Molecular Pathology. 90 (2): 231–237. doi:10.1016/j.yexmp.2011.01.001. PMID 21241689.
 Not done for now: Might you condense this to make it a little bit more technical and instead more generally readable? Likeanechointheforest (talk) 18:39, 22 August 2025 (UTC)[reply]

Add photo

[edit]

Please add this photo to the article: Alberto_Izzotti.jpg HRShami (talk) 11:18, 26 August 2025 (UTC)[reply]

 Done AlphaBetaGamma (Talk/report any mistakes here) 14:25, 26 August 2025 (UTC)[reply]

Research and work section update

[edit]

Please note: Based on the comments of the reviewer above, I have condensed the section. To see the original text, declined by the reviewer, please see this edit.

I have changed some references and provided details here of where each statement is taken from. Please note his name is misspelled in some references as Izzoti or Izotti.

Please replace the current research section with the text below.

In his research related to chemoprevention and cancer, Izzotti studied the effectiveness of chemopreventive drugs in preventing cancer and other mutation-related diseases. He studied the mechanisms through which these drugs work, particularly in relation to smoking-related outcomes and showed that these medicines can reduce DNA damage and other cancer related effects in preclinical models.[page 26, paragraph 2] [1]

Izzotti also investigated how microRNA (miRNA), which are small molecules that regulate gene expression, respond to noxious agents in healthy tissues. His studies demonstrated that miRNA impairment in lungs is induced by exposure to cigarette smoke. [page 2, paragraph 2] [2] In related research, he also deduced the presence of extra-cellular miRNAs in biological fluids in order to determine their feasibility as potential cancer markers that can be detected through non-invasive procedures. [page 4, paragraph 4 and paragraph 6] [3] Izzotti also explored the use of oral ozonized oils as a complementary therapy alongside conventional cancer treatments.[4]

Beyond cancer, Izzotti investigated the causes of the molecular mechanisms responsible for the development of glaucoma and found significantly higher levels of 8-hydroxy-2′-deoxyguanosine (8-OH-dG) in the trabecular meshwork of eyes of glaucoma patients.[please search reference 103] [5] In similar research, he examined the levels of 8-OH-dG in relation to intraocular pressure, visual field damage, and disease duration. [Line 8, page 235] The results of this study found the presence of oxidative damage alongside neuronal cell death in optic nerves among patients with primary open-angle glaucoma (POAG), [line 42, page 235] which supported the possible pathogenetic role of this phenomenon. [Line 30, page 235] He also analyzed the role of mitochondrial damage in the eye of POAG patients and found that mitochondrial DNA deletion was significantly increased in the human trabecular meshwork within POAG patients. [Line 40, page 235][6]

Clean text
In his research related to chemoprevention and cancer, Izzotti studied the effectiveness of chemopreventive drugs in preventing cancer and other mutation-related diseases. He studied the mechanisms through which these drugs work, particularly in relation to smoking-related outcomes and showed that these medicines can reduce DNA damage and other cancer related effects in preclinical models.[7]

Izzotti also investigated how microRNA (miRNA), which are small molecules that regulate gene expression, respond to noxious agents in healthy tissues. His studies demonstrated that miRNA impairment in lungs is induced by exposure to cigarette smoke.[8] In related research, he also deduced the presence of extra-cellular miRNAs in biological fluids in order to determine their feasibility as potential cancer markers that can be detected through non-invasive procedures.[9] Izzotti also explored the use of oral ozonized oils as a complementary therapy alongside conventional cancer treatments.[10]

Beyond cancer, Izzotti investigated the causes of the molecular mechanisms responsible for the development of glaucoma and found significantly higher levels of 8-hydroxy-2′-deoxyguanosine (8-OH-dG) in the trabecular meshwork of eyes of glaucoma patients.[11] In similar research, he examined the levels of 8-OH-dG in relation to intraocular pressure, visual field damage, and disease duration. The results of this study found the presence of oxidative damage alongside neuronal cell death in optic nerves among patients with primary open-angle glaucoma (POAG), which supported the possible pathogenetic role of this phenomenon. He also analyzed the role of mitochondrial damage in the eye of POAG patients and found that mitochondrial DNA deletion was significantly increased in the human trabecular meshwork within POAG patients.[12]

References

  1. ^ Szirmai, Mónika; Juhász, Krisztina; Bertha, András; Gombos, Katalin; Révész, Péter; Ember, István (1 April 2012). "Potential Chemopreventive Effect Of "Procont"On Mirna Expression In CBA/CA Mice". European Medical, Health and Pharmaceutical Journal. 3. doi:10.12955/emhpj.v3i0.350.
  2. ^ Russ, Rebecca; Slack, Frank J. (2012). "Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis". Pulmonary Medicine. 2012: 1–9. doi:10.1155/2012/791234.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  3. ^ Donzelli, Sara; Farneti, Alessia; Marucci, Laura; Ganci, Federica; Sacconi, Andrea; Strano, Sabrina; Sanguineti, Giuseppe; Blandino, Giovanni (21 April 2020). "Non-coding RNAs as Putative Biomarkers of Cancer-Associated Cachexia". Frontiers in Cell and Developmental Biology. 8: 257. doi:10.3389/fcell.2020.00257. PMC 7187787. PMID 32373612.
  4. ^ Ferrante, Margherita; Oliveri Conti, Gea; Vito, Domenico; Fernandez, Gabriela; Maione, Carol; Lauriola, Paolo; Piscitelli, Prisco; Jimenez Gomes Tagle, Melissa; Dora, Carlos; Serrano Pons, Jordi; Conforti, Carole; Panisello, Joima; Sol Ventura, Paula; Bernotti, Ilaria; Ruiz Martin, Carmen; Buloz, Edgar; Trombetta, Marcella; Banfi, Giuseppe; Tageo, Valentina (15 April 2024). "Preface and Abstracts of the 2nd International One Health Conference": 5. doi:10.3390/msf2024025005. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: unflagged free DOI (link)
  5. ^ Passaro, Maria Laura; Matarazzo, Francesco; Abbadessa, Gianmarco; Pezone, Antonio; Porcellini, Antonio; Tranfa, Fausto; Rinaldi, Michele; Costagliola, Ciro (2 November 2023). "Glaucoma as a Tauopathy—Is It the Missing Piece in the Glaucoma Puzzle?". Journal of Clinical Medicine. 12 (21): 6900. doi:10.3390/jcm12216900.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Majsterek, Ireneusz; Malinowska, Katarzyna; Stanczyk, Malgorzata; Kowalski, Michal; Blaszczyk, Jan; Kurowska, Anna K.; Kaminska, Anna; Szaflik, Jerzy; Szaflik, Jacek P. (April 2011). "Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma". Experimental and Molecular Pathology. 90 (2): 231–237. doi:10.1016/j.yexmp.2011.01.001. PMID 21241689.
  7. ^ Szirmai, Mónika; Juhász, Krisztina; Bertha, András; Gombos, Katalin; Révész, Péter; Ember, István (1 April 2012). "Potential Chemopreventive Effect Of "Procont"On Mirna Expression In CBA/CA Mice". European Medical, Health and Pharmaceutical Journal. 3. doi:10.12955/emhpj.v3i0.350.
  8. ^ Russ, Rebecca; Slack, Frank J. (2012). "Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis". Pulmonary Medicine. 2012: 1–9. doi:10.1155/2012/791234.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  9. ^ Donzelli, Sara; Farneti, Alessia; Marucci, Laura; Ganci, Federica; Sacconi, Andrea; Strano, Sabrina; Sanguineti, Giuseppe; Blandino, Giovanni (21 April 2020). "Non-coding RNAs as Putative Biomarkers of Cancer-Associated Cachexia". Frontiers in Cell and Developmental Biology. 8: 257. doi:10.3389/fcell.2020.00257. PMC 7187787. PMID 32373612.
  10. ^ Ferrante, Margherita; Oliveri Conti, Gea; Vito, Domenico; Fernandez, Gabriela; Maione, Carol; Lauriola, Paolo; Piscitelli, Prisco; Jimenez Gomes Tagle, Melissa; Dora, Carlos; Serrano Pons, Jordi; Conforti, Carole; Panisello, Joima; Sol Ventura, Paula; Bernotti, Ilaria; Ruiz Martin, Carmen; Buloz, Edgar; Trombetta, Marcella; Banfi, Giuseppe; Tageo, Valentina (15 April 2024). "Preface and Abstracts of the 2nd International One Health Conference": 5. doi:10.3390/msf2024025005. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: unflagged free DOI (link)
  11. ^ Passaro, Maria Laura; Matarazzo, Francesco; Abbadessa, Gianmarco; Pezone, Antonio; Porcellini, Antonio; Tranfa, Fausto; Rinaldi, Michele; Costagliola, Ciro (2 November 2023). "Glaucoma as a Tauopathy—Is It the Missing Piece in the Glaucoma Puzzle?". Journal of Clinical Medicine. 12 (21): 6900. doi:10.3390/jcm12216900.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  12. ^ Majsterek, Ireneusz; Malinowska, Katarzyna; Stanczyk, Malgorzata; Kowalski, Michal; Blaszczyk, Jan; Kurowska, Anna K.; Kaminska, Anna; Szaflik, Jerzy; Szaflik, Jacek P. (April 2011). "Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma". Experimental and Molecular Pathology. 90 (2): 231–237. doi:10.1016/j.yexmp.2011.01.001. PMID 21241689.

HRShami (talk) 06:12, 19 September 2025 (UTC)[reply]

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